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Gkogkolou, P., Sarna, M., Sarna, T., Paus, R., Luger, T. A. & Böhm, M., Apr 1 2019, In : The British journal of dermatology. 180, 4, p. e108-e139

Research output: Contribution to journalArticle

Open Access
Keratinocytes
Glucose
Skin Ulcer
Foot Ulcer
Skin

Adenosine Promotes Human Hair Growth and Inhibits Catagen Transition In Vitro: Role of the Outer Root Sheath Keratinocytes

Lisztes, E., Tóth, B. I., Bertolini, M., Szabó, I. L., Zákány, N., Oláh, A., Szöllősi, A. G., Paus, R. & Bíró, T., Jan 1 2019, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata

Laufer Britva, R., Keren, A., Paus, R. & Gilhar, A., Jan 1 2019, (Accepted/In press) In : British Journal of Dermatology.

Research output: Contribution to journalLetter

Alopecia Areata
tofacitinib
apremilast
3 Citations (Scopus)

Assessment of Quality of Life and Treatment Outcomes of Patients with Persistent Postchemotherapy Alopecia

Freites-Martinez, A., Chan, D., Sibaud, V., Shapiro, J., Fabbrocini, G., Tosti, A., Cho, J., Goldfarb, S., Modi, S., Gajria, D., Norton, L., Paus, R., Cigler, T. & Lacouture, M. E., Jan 1 2019, In : JAMA dermatology.

Research output: Contribution to journalArticle

Alopecia
Quality of Life
Drug Therapy
Therapeutics
Minoxidil
1 Citation (Scopus)

CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia

Purba, T. S., Ng'andu, K., Brunken, L., Smart, E., Mitchell, E., Hassan, N., O'Brien, A., Mellor, C., Jackson, J., Shahmalak, A. & Paus, R., Oct 1 2019, In : EMBO Molecular Medicine. 11, 10, e11031.

Research output: Contribution to journalArticle

Open Access
Alopecia
Stem Cells
docetaxel
Paclitaxel
Drug Therapy
3 Citations (Scopus)

Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen–anagen transformation

Hawkshaw, N. J., Hardman, J. A., Alam, M., Jimenez, F. & Paus, R., Jan 1 2019, (Accepted/In press) In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Hair
Hair Follicle
Ligands
Stem Cells
Scalp
1 Citation (Scopus)

Distinct Patterns of Hair Graft Survival After Transplantation Into 2 Nonhealing Ulcers: Is Location Everything?

Alam, M., Cooley, J., Plotczyk, M., Martínez-Martín, M. S., Izeta, A., Paus, R. & Jimenez, F., Apr 1 2019, In : Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 45, 4, p. 557-565 9 p.

Research output: Contribution to journalArticle

Graft Survival
Hair
Ulcer
Cicatrix
Transplantation
6 Citations (Scopus)

Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle?

Nicu, C., Hardman, J. A., Pople, J. & Paus, R., Jan 1 2019, In : Experimental dermatology.

Research output: Contribution to journalArticle

Open Access
Lipogenesis
Lipolysis
Adipocytes
Hair
Switches

Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias

Harries, M., Imanishi, H. & Paus, R., Jun 1 2019, In : Journal of the American Academy of Dermatology. 80, 6, p. e165-e166

Research output: Contribution to journalLetter

Open Access
Epithelial-Mesenchymal Transition
Alopecia
Fibrosis
Stem Cells
1 Citation (Scopus)

Frontiers in alopecia areata pathobiology research

Gilhar, A., Britva, R. L., Keren, A. & Paus, R., Jan 1 2019, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalReview article

Alopecia Areata
Research
T-Lymphocytes
Regulatory T-Lymphocytes
Natural Killer T-Cells

Getting ready for the next decade of Experimental Dermatology

Plikus, M. V. & Paus, R., Nov 1 2019, In : Experimental dermatology. 28, 11, p. 1199-1200 2 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Growth Hormone Operates as a Neuroendocrine Regulator of Human Hair Growth Ex Vivo

Alam, M., Below, D. A., Chéret, J., Langan, E. A., Bertolini, M., Jimenez, F. & Paus, R., Jan 1 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Hair
Growth Hormone
Growth
5 Citations (Scopus)

Hair disorders in cancer survivors

Freites-Martinez, A., Shapiro, J., van den Hurk, C., Goldfarb, S., Jimenez, J. J., Rossi, A. M., Paus, R. & Lacouture, M. E., May 1 2019, In : Journal of the American Academy of Dermatology. 80, 5, p. 1199-1213 15 p.

Research output: Contribution to journalReview article

Alopecia
Neoplasms
Radiotherapy
Hypertrichosis
Growth Disorders
6 Citations (Scopus)

Hair disorders in patients with cancer

Freites-Martinez, A., Shapiro, J., Goldfarb, S., Nangia, J., Jimenez, J. J., Paus, R. & Lacouture, M. E., May 1 2019, In : Journal of the American Academy of Dermatology. 80, 5, p. 1179-1196 18 p.

Research output: Contribution to journalReview article

Hair
Alopecia
Hirsutism
Neoplasms
Quality of Life
2 Citations (Scopus)

Hair growth control by innate immunocytes: Perifollicular macrophages revisited

Muneeb, F., Hardman, J. A. & Paus, R., Apr 1 2019, In : Experimental dermatology. 28, 4, p. 425-431 7 p.

Research output: Contribution to journalArticle

Macrophages
Hair Follicle
Growth
Growth Disorders
T-cells
6 Citations (Scopus)

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

Clayton, R. W., Göbel, K., Niessen, C. M., Paus, R., van Steensel, M. A. M. & Lim, X., Jan 1 2019, In : British Journal of Dermatology.

Research output: Contribution to journalReview article

Sebaceous Glands
Acne Vulgaris
Sebum
Homeostasis
Skin
2 Citations (Scopus)

Human Perifollicular Macrophages Undergo Apoptosis, Express Wnt Ligands, and Switch their Polarization during Catagen

Hardman, J. A., Muneeb, F., Pople, J., Bhogal, R., Shahmalak, A. & Paus, R., Dec 2019, In : Journal of Investigative Dermatology. 139, 12, p. 2543-2546.e9

Research output: Contribution to journalArticle

Macrophages
Switches
Polarization
Apoptosis
Ligands

Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo

Lehmann, J., Kemper, B., Barroso Peña, A., Schnekenburger, J., Paus, R., Bertolini, M. & Chéret, J., May 1 2019, In : British Journal of Dermatology. 180, 5, p. e141

Research output: Contribution to journalLetter

Open Access
Hair Follicle
Optical Coherence Tomography

Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage

Smart, E., Farjo, N., Farjo, B., Haslam, I. S. & Paus, R., Jul 1 2019, In : Journal of dermatological science. 95, 1, p. 44-47 4 p.

Research output: Contribution to journalLetter

Open Access
ATP-Binding Cassette Transporters
Chemotherapy
Hair Follicle
Drug Therapy
2 Citations (Scopus)

Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis

Leon, A., Rosen, J. D., Hashimoto, T., Fostini, A. C., Paus, R. & Yosipovitch, G., Jan 1 2019, In : Experimental dermatology.

Research output: Contribution to journalReview article

Open Access
Immune system
Neurology
Pruritus
Scalp
Psoriasis
7 Citations (Scopus)

JAK inhibitors and alopecia areata

Gilhar, A., Keren, A. & Paus, R., Jan 26 2019, In : The Lancet. 393, 10169, p. 318-319 2 p.

Research output: Contribution to journalLetter

Alopecia Areata

Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo

Hundt, J. E., Sass, S., Funk, W., Bíró, T., Farman, N., Langan, E. A. & Paus, R., Jan 1 2019, (Accepted/In press) In : Skin Pharmacology and Physiology.

Research output: Contribution to journalArticle

Mineralocorticoid Receptor Antagonists
Mineralocorticoid Receptors
Hair
Hair Follicle
Growth
1 Citation (Scopus)

Nestin + progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo

Liao, T., Lehmann, J., Sternstein, S., Yay, A., Zhang, G., Matthießen, A. E., Schumann, S., Siemers, F., Kruse, C., Hundt, J. E., Langan, E. A., Tiede, S. & Paus, R., Jan 1 2019, In : Archives of Dermatological Research.

Research output: Contribution to journalArticle

Open Access
Nestin
Sweat Glands
Stem Cells
Wound Healing
Skin

PPAR-γ signalling as a key mediator of human hair follicle physiology and pathology

Ramot, Y., Bertolini, M., Boboljova, M., Uchida, Y. & Paus, R., Jan 1 2019, (Accepted/In press) In : Experimental dermatology.

Research output: Contribution to journalReview article

Open Access
Peroxisome Proliferator-Activated Receptors
Hair Follicle
Physiology
Pathology
Alopecia

Schwann cells as underestimated, major players in human skin physiology and pathology

Bray, E. R., Chéret, J., Yosipovitch, G. & Paus, R., Jan 1 2019, (Accepted/In press) In : Experimental dermatology.

Research output: Contribution to journalArticle

Open Access
Skin Physiological Phenomena
Schwann Cells
Physiology
Pathology
Skin
1 Citation (Scopus)

Seborrheic dermatitis—Looking beyond Malassezia

Wikramanayake, T. C., Borda, L. J., Miteva, M. & Paus, R., Jan 1 2019, (Accepted/In press) In : Experimental dermatology.

Research output: Contribution to journalReview article

Dermatitis
Malassezia
Skin
Microbiota
Causality

Theophylline exerts complex anti-ageing and anti-cytotoxicity effects in human skin ex vivo

Bertolini, M., Ramot, Y., Gherardini, J., Heinen, G., Chéret, J., Welss, T., Giesen, M., Funk, W. & Paus, R., Jan 1 2019, (Accepted/In press) In : International journal of cosmetic science.

Research output: Contribution to journalArticle

Cytotoxicity
Theophylline
Skin
Aging of materials
Proteins

The Phytocannabinoid (–)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar versus Hair Growth Inhibitory Micromolar Effects

Szabó, I. L., Lisztes, E., Béke, G., Tóth, K. F., Paus, R., Oláh, A. & Bíró, T., Jan 1 2019, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Cannabidiol
Hair
Modulators
Anti-Inflammatory Agents
Growth
1 Citation (Scopus)

Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo

Zhang, G. Y., Langan, E. A., Meier, N. T., Funk, W., Siemers, F. & Paus, R., Mar 1 2019, In : PloS one. 14, 3, e0212659.

Research output: Contribution to journalArticle

Open Access
Re-Epithelialization
L-thyroxine
thyroxine
angiogenesis
tissue repair
3 Citations (Scopus)

Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine

Gherardini, J., Wegner, J., Chéret, J., Ghatak, S., Lehmann, J., Alam, M., Jimenez, F., Funk, W., Böhm, M., Botchkareva, N. V., Ward, C., Paus, R. & Bertolini, M., Apr 1 2019, In : International journal of cosmetic science. 41, 2, p. 164-182 19 p.

Research output: Contribution to journalArticle

Open Access
Caffeine
Hair Follicle
Scalp
Ultraviolet radiation
Skin
3 Citations (Scopus)

TRPV4 Is Expressed in Human Hair Follicles and Inhibits Hair Growth In Vitro

Szabó, I. L., Herczeg-Lisztes, E., Szegedi, A., Nemes, B., Paus, R., Bíró, T. & Szöllősi, A. G., Jan 1 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Hair Follicle
Hair
Growth
In Vitro Techniques

Y-27632 preserves epidermal integrity in a human skin organ-culture (hSOC) system by regulating AKT and ERK signaling pathways

Zhang, X., Qin, J., Xie, Z., Liu, C., Su, Y., Chen, Z., Zhou, Q., Ma, C., Liu, G., Paus, R., Guo, J. & Wu, X., Nov 2019, In : Journal of dermatological science. 96, 2, p. 99-109 11 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Organ Culture Techniques
Skin
Keratinocytes
Cell proliferation
2018
1 Citation (Scopus)

A guide to studying human dermal adipocytes in situ

Nicu, C., Pople, J., Bonsell, L., Bhogal, R., Ansell, D. M. & Paus, R., Jun 1 2018, In : Experimental Dermatology. 27, 6, p. 589-602 14 p.

Research output: Contribution to journalReview article

Adipocytes
Skin
Tissue
White Adipose Tissue
Lipids

Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling

Dobreva, A., Paus, R. & Cogan, N. G., Jan 1 2018, In : Mathematical Medicine and Biology. 35, 3, p. 387-407 21 p.

Research output: Contribution to journalArticle

Alopecia Areata
Hair Follicle
Cycling
hair
Disorder
2 Citations (Scopus)

An efficient method for eccrine gland isolation from human scalp

Jimenez, F., Alam, M., Hernandez, I., Poblet, E., Hardman, J. A. & Paus, R., Jun 1 2018, In : Experimental Dermatology. 27, 6, p. 678-681 4 p.

Research output: Contribution to journalArticle

Eccrine Glands
Scalp
Grafts
Microdissection
Transplantation (surgical)
3 Citations (Scopus)

A technique for more precise distinction between catagen and telogen human hair follicles ex vivo

Hernandez, I., Alam, M., Platt, C., Hardman, J., Smart, E., Poblet, E., Bertolini, M., Paus, R. & Jimenez, F., Sep 1 2018, In : Journal of the American Academy of Dermatology. 79, 3, p. 558-559 2 p.

Research output: Contribution to journalArticle

Hair Follicle
8 Citations (Scopus)

Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture

Parodi, C., Hardman, J. A., Allavena, G., Marotta, R., Catelani, T., Bertolini, M., Paus, R. & Grimaldi, B., Mar 1 2018, In : PLoS biology. 16, 3, p. e2002864

Research output: Contribution to journalArticle

Open Access
hair follicles
organ culture
human growth
Hair Follicle
autophagy
7 Citations (Scopus)

Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex

Romano, M. T., Tafazzoli, A., Mattern, M., Sivalingam, S., Wolf, S., Rupp, A., Thiele, H., Altmüller, J., Nürnberg, P., Ellwanger, J., Gambon, R., Baumer, A., Kohlschmidt, N., Metze, D., Holdenrieder, S., Paus, R., Lütjohann, D., Frank, J., Geyer, M., Bertolini, M. & 2 others, Kokordelis, P. & Betz, R. C., Nov 1 2018, In : American Journal of Human Genetics. 103, 5, p. 777-785 9 p.

Research output: Contribution to journalArticle

Hair Follicle
Cholesterol
Mutation
Hair
Alopecia
1 Citation (Scopus)

Bridging the "dead hair"-"live follicle" divide in applied hair research

Bertolini, M., Botchkareva, N., Westgate, G., Ward, C., Cornwell, P. & Paus, R., Sep 1 2018, In : Journal of Cosmetic Science. 69, 5, p. 315-322 8 p.

Research output: Contribution to journalArticle

Hair Follicle
Hair
Cosmetics
Research
Structural properties
5 Citations (Scopus)

Cover Image: Neuroendocrine treatment of inherited keratin disorders by cannabinoids?

Ramot, Y., Oláh, A. & Paus, R., Jun 1 2018, In : British Journal of Dermatology. 178, 6, 1 p.

Research output: Contribution to journalLetter

Cannabinoids
Keratins
13 Citations (Scopus)

Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion

Sardella, C., Winkler, C., Quignodon, L., Hardman, J. A., Toffoli, B., Giordano Attianese, G. M. P., Hundt, J. E., Michalik, L., Vinson, C. R., Paus, R., Desvergne, B. & Gilardi, F., Mar 1 2018, In : Journal of Investigative Dermatology. 138, 3, p. 500-510 11 p.

Research output: Contribution to journalArticle

Hair Follicle
Morphogenesis
Peroxisome Proliferator-Activated Receptors
Skin
Sebaceous Glands
8 Citations (Scopus)

Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal

Foster, A. R., Nicu, C., Schneider, M. R., Hinde, E. & Paus, R., Jul 1 2018, In : Archives of Dermatological Research. 310, 5, p. 453-462 10 p.

Research output: Contribution to journalArticle

White Adipose Tissue
Hair Follicle
Skin
Hair
Adipocytes
13 Citations (Scopus)

Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue

Poblet, E., Jimenez, F., Escario-Travesedo, E., Hardman, J. A., Hernández-Hernández, I., Agudo-Mena, J. L., Cabrera-Galvan, J. J., Nicu, C. & Paus, R., May 1 2018, In : British Journal of Dermatology. 178, 5, p. 1163-1172 10 p.

Research output: Contribution to journalArticle

Eccrine Glands
Sweat Glands
White Adipose Tissue
Hair Follicle
Skin
16 Citations (Scopus)

Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris

Imanishi, H., Ansell, D. M., Chéret, J., Harries, M., Bertolini, M., Sepp, N., Bíró, T., Poblet, E., Jimenez, F., Hardman, J., Panicker, S. P., Ward, C. M. & Paus, R., Mar 1 2018, In : Journal of Investigative Dermatology. 138, 3, p. 511-519 9 p.

Research output: Contribution to journalArticle

Lichens
Epithelial-Mesenchymal Transition
Stem cells
Mesenchymal Stromal Cells
Transforming Growth Factors
2 Citations (Scopus)

Fluorescent cell tracer dye permits real-time assessment of re-epithelialization in a serum-free ex vivo human skin wound assay

Nasir, N. A. M., Paus, R. & Ansell, D. M., Jan 1 2018, (Accepted/In press) In : Wound Repair and Regeneration.

Research output: Contribution to journalArticle

Re-Epithelialization
Coloring Agents
Skin
Wounds and Injuries
Serum
17 Citations (Scopus)

Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

Paus, R., Bulfone-Paus, S. & Bertolini, M., Jan 1 2018, In : Journal of Investigative Dermatology Symposium Proceedings. 19, 1, p. S12-S17

Research output: Contribution to journalReview article

Alopecia Areata
Hair Follicle
Melanocyte-Stimulating Hormones
Tacrolimus
Autoimmune Diseases
4 Citations (Scopus)

How chemotherapy and radiotherapy damage the tissue: Comparative biology lessons from feather and hair models

Gao, Q. X., Zhou, G. X., Lin, S. J., Paus, R. & Yue, Z. C., Jan 1 2018, (Accepted/In press) In : Experimental Dermatology.

Research output: Contribution to journalArticle

Feathers
Chemotherapy
Radiotherapy
Tissue
Drug Therapy
50 Citations (Scopus)

How UV Light Touches the Brain and Endocrine System Through Skin, and Why

Slominski, A. T., Zmijewski, M. A., Plonka, P. M., Szaflarski, J. P. & Paus, R., May 1 2018, In : Endocrinology. 159, 5, p. 1992-2007 16 p.

Research output: Contribution to journalReview article

Endocrine System
Touch
Ultraviolet Rays
Skin
Brain
13 Citations (Scopus)

Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

Hawkshaw, N. J., Hardman, J. A., Haslam, I. S., Shahmalak, A., Gilhar, A., Lim, X. & Paus, R., May 8 2018, In : PLoS Biology. 16, 5, e2003705.

Research output: Contribution to journalArticle

hair follicles
cyclosporine
Hair Follicle
alopecia
Alopecia
1 Citation (Scopus)

Image Gallery: Intravital visualization of the dynamic changes in human hair follicle cycling

Alam, M., Hernandez, I., Paus, R. & Jimenez, F., Jun 1 2018, In : British Journal of Dermatology. 178, 6, p. e396

Research output: Contribution to journalLetter

Hair Follicle