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    Ronald Charles Desrosiers
2020

A recombinant rhesus monkey rhadinovirus deleted of glycoprotein L establishes persistent infection of rhesus macaques and elicits conventional T cell responses

Hahn, A. S., Bischof, G. F., Großkopf, A. K., Shin, Y. C., Domingues, A., Gonzalez-Nieto, L., Rakasz, E. G., Watkins, D. I., Ensser, A., Martins, M. A. & Desrosiers, R. C., Jan 1 2020, In : Journal of virology. 94, 2, e01093-19.

Research output: Contribution to journalArticle

Rhadinovirus
Macaca mulatta
glycoproteins
Glycoproteins
T-lymphocytes
1 Citation (Scopus)

Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys

Fuchs, S. P., Martinez-Navio, J. M., Rakasz, E. G., Gao, G. & Desrosiers, R. C., Mar 13 2020, In : Molecular Therapy - Methods and Clinical Development. 16, p. 94-102 9 p.

Research output: Contribution to journalArticle

Open Access
Dependovirus
Humoral Immunity
Macaca mulatta
Immunoglobulins
Anti-Idiotypic Antibodies
2019
10 Citations (Scopus)

Adeno-Associated Virus Delivery of Anti-HIV Monoclonal Antibodies Can Drive Long-Term Virologic Suppression

Martinez-Navio, J. M., Fuchs, S. P., Pantry, S. N., Lauer, W. A., Duggan, N. N., Keele, B. F., Rakasz, E. G., Gao, G., Lifson, J. D. & Desrosiers, R. C., Mar 19 2019, In : Immunity. 50, 3, p. 567-575.e5

Research output: Contribution to journalArticle

Dependovirus
HIV Antibodies
Neutralizing Antibodies
Haplorhini
Anti-Idiotypic Antibodies
1 Citation (Scopus)

A highly unusual v1 region of env in an elite controller of HIV infection

Silver, Z. A., Dickinson, G., Seaman, M. S. & Desrosiers, R. C., May 1 2019, In : Journal of Virology. 93, 10, e00094-19.

Research output: Contribution to journalArticle

Open Access
HIV infections
Human immunodeficiency virus 1
HIV Infections
HIV-1
neutralization
7 Citations (Scopus)

Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies

Gardner, M. R., Fetzer, I., Kattenhorn, L. M., Davis-Gardner, M. E., Zhou, A. S., Alfant, B., Weber, J. A., Kondur, H. R., Martinez-Navio, J. M., Fuchs, S. P., Desrosiers, R. C., Gao, G., Lifson, J. D. & Farzan, M., Jan 1 2019, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Dependovirus
Neutralizing Antibodies
Antibody Formation
HIV-1
Anti-Idiotypic Antibodies
2 Citations (Scopus)

Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity

Xiao, Y., Muhuri, M., Li, S., Qin, W., Xu, G., Luo, L., Li, J., Letizia, A. J., Wang, S. K., Chan, Y. K., Wang, C., Fuchs, S. P., Wang, D., Su, Q., Abu Nahid, M., Church, G. M., Farzan, M., Yang, L., Wei, Y., Desrosiers, R. C. & 3 others, Mueller, C., Tai, P. W. L. & Gao, G., Jul 11 2019, In : JCI Insight. 4, 13, e99052.

Research output: Contribution to journalArticle

Open Access
Ovalbumin
Antigen-Presenting Cells
Humoral Immunity
Transgenes
Cellular Immunity
4 Citations (Scopus)

EphA7 Functions as Receptor on BJAB Cells for Cell-to-Cell Transmission of the Kaposi's Sarcoma-Associated Herpesvirus and for Cell-Free Infection by the Related Rhesus Monkey Rhadinovirus

Großkopf, A. K., Schlagowski, S., Hörnich, B. F., Fricke, T., Desrosiers, R. C. & Hahn, A. S., Aug 1 2019, In : Journal of virology. 93, 15

Research output: Contribution to journalArticle

Rhadinovirus
Human herpesvirus 8
Human Herpesvirus 8
Macaca mulatta
receptors

The frequency of vaccine-induced T-cell responses does not predict the rate of acquisition after repeated intrarectal SIVmac239 challenges in MAMU-B*08 rhesus macaques

Martins, M., Gonzalez-Nieto, L., Shin, Y. C., Domingues, A., Gutman, M. J., Maxwell, H. S., Magnani, D. M., Ricciardi, M. J., Pedreño-Lopez, N., Bailey, V. K., Altman, J. D., Parks, C. L., Allison, D. B., Ejima, K., Rakasz, E. G., Capuano, S., Desrosiers, R. C., Lifson, J. D. & Watkins, D., Mar 1 2019, In : Journal of Virology. 93, 5, e01626-18.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Macaca mulatta
Vaccines
T-lymphocytes

Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques

Gonzalez-Nieto, L., Castro, I. M., Bischof, G. F., Shin, Y. C., Ricciardi, M. J., Bailey, V. K., Dang, C. M., Pedreño-Lopez, N., Magnani, D. M., Ejima, K., Allison, D. B., Gil, H. M., Evans, D. T., Rakasz, E. G., Lifson, J. D., Desrosiers, R. C. & Martins, M. A., Jan 1 2019, In : PLoS pathogens. 15, 9, e1008015.

Research output: Contribution to journalArticle

Open Access
Macaca mulatta
Vaccines
Ribosomal DNA
CTLA-4 Antigen
HIV
2 Citations (Scopus)

Vaccine protection against SIVmac239 acquisition

Martins, M., Bischof, G. F., Shin, Y. C., Lauer, W. A., Gonzalez-Nieto, L., Watkins, D., Rakasz, E. G., Lifson, J. D. & Desrosiers, R. C., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1739-1744 6 p.

Research output: Contribution to journalArticle

Vaccines
Immunity
Herpesviridae
Macaca mulatta
Cellular Immunity
2018
8 Citations (Scopus)

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi’s sarcoma-associated herpesvirus and rhesus monkey rhadinovirus

Großkopf, A. K., Ensser, A., Neipel, F., Jungnickl, D., Schlagowski, S., Desrosiers, R. C. & Hahn, A. S., Feb 1 2018, In : PLoS Pathogens. 14, 2, e1006912.

Research output: Contribution to journalArticle

Rhadinovirus
Eph Family Receptors
Human Herpesvirus 8
Macaca mulatta
Glycoproteins
4 Citations (Scopus)

A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products

Shin, Y. C., Bischof, G. F., Lauer, W. A., Gonzalez-Nieto, L., Rakasz, E. G., Hendricks, G. M., Watkins, D., Martins, M. & Desrosiers, R. C., Jun 1 2018, In : PLoS Pathogens. 14, 6, e1007143.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virion
Genome
Genes
Rhadinovirus
18 Citations (Scopus)

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques

Magnani, D. M., Rogers, T. F., Maness, N. J., Grubaugh, N. D., Beutler, N., Bailey, V. K., Gonzalez-Nieto, L., Gutman, M. J., Pedreño-Lopez, N., Kwal, J. M., Ricciardi, M. J., Myers, T. A., Julander, J. G., Bohm, R. P., Gilbert, M. H., Schiro, F., Aye, P. P., Blair, R. V., Martins, M., Falkenstein, K. P. & 12 others, Kaur, A., Curry, C., Kallas, E. G., Desrosiers, R. C., Goldschmidt-Clermont, P., Whitehead, S. S., Andersen, K. G., Bonaldo, M. C., Lackner, A. A., Panganiban, A. T., Burton, D. R. & Watkins, D., Dec 1 2018, In : Nature Communications. 9, 1, 1624.

Research output: Contribution to journalArticle

Fetal Death
Macaca
viruses
infectious diseases
antibodies
1 Citation (Scopus)

Mamu-B*17+ rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication

Martins, M., Tully, D. C., Pedreño-Lopez, N., Bredow, B. V., Pauthner, M. G., Shin, Y. C., Yuan, M., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Altman, J. D., Burton, D. R., Ejima, K., Allison, D. B. & 9 others, Evans, D. T., Rakasz, E. G., Parks, C. L., Bonaldo, M. C., Capuano, S., Lifson, J. D., Desrosiers, R. C., Allen, T. M. & Watkins, D., Aug 1 2018, In : Journal of Virology. 92, 16, e00690-18.

Research output: Contribution to journalArticle

Macaca mulatta
Simian immunodeficiency virus
Simian Immunodeficiency Virus
virus replication
major histocompatibility complex
1 Citation (Scopus)

With differences in acute viremia in simian immunodeficiency virus δnef-infected animals

Janaka, S. K., Tavakoli-Tameh, A., Neidermyer, W. J., Serra-Moreno, R., Hoxie, J. A., Desrosiers, R. C., Paul Johnson, R., Lifson, J. D., Wolinsky, S. M. & Evans, D. T., Nov 1 2018, In : Journal of Virology. 92, 22, e00542.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Viremia
viremia
Macaca mulatta
2017
9 Citations (Scopus)

A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus

Magnani, D. M., Silveira, C. G. T., Rosen, B. C., Ricciardi, M. J., Pedreño-Lopez, N., Gutman, M. J., Bailey, V. K., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Avelino-Silva, V. I., Trindade, M., Nogueira, J., Oliveira, C. S., Maestri, A., Felix, A. C., Levi, J. E., Nogueira, M. L., Martins, M., Martinez-Navio, J. M. & 6 others, Fuchs, S. P., Whitehead, S. S., Burton, D. R., Desrosiers, R. C., Kallas, E. G. & Watkins, D., Jun 12 2017, In : PLoS Neglected Tropical Diseases. 11, 6, e0005655.

Research output: Contribution to journalArticle

Immunodominant Epitopes
Antibodies
Immunoglobulin Genes
Dengue Virus
Neutralizing Antibodies
2 Citations (Scopus)

Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys

Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Pedreño-Lopez, N., Silveira, C. G. T., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Su, Q., Newman, R. M., Pack, M., Martins, M., Martinez-Navio, J. M., Fuchs, S. P., Rakasz, E. G., Allen, T. M., Whitehead, S. S., Burton, D. R., Gao, G. & 3 others, Desrosiers, R. C., Kallas, E. G. & Watkins, D., Oct 4 2017, In : Molecular Therapy. 25, 10, p. 2323-2331 9 p.

Research output: Contribution to journalArticle

Dengue Virus
Neutralizing Antibodies
Macaca mulatta
Dependovirus
Antibody-Dependent Enhancement
3 Citations (Scopus)

HEK293T cell lines defective for O-linked glycosylation

Termini, J. M., Silver, Z. A., Connor, B., Antonopoulos, A., Haslam, S. M., Dell, A. & Desrosiers, R. C., Jun 1 2017, In : PLoS One. 12, 6, e0179949.

Research output: Contribution to journalArticle

Galactokinase
Glycosylation
glycosylation
galactokinase
Galactose
2 Citations (Scopus)

Human immunodeficiency virus and simian immunodeficiency virus maintain high levels of infectivity in the complete absence of mucin-type O-glycosylation

Termini, J. M., Church, E. S., Silver, Z. A., Haslam, S. M., Dell, A. & Desrosiers, R. C., Oct 1 2017, In : Journal of Virology. 91, 19, e01228-17.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
mucins
Human immunodeficiency virus
Mucins
2 Citations (Scopus)

Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection

Postler, T. S., Pantry, S. N., Desrosiers, R. C. & Ghosh, S., Nov 1 2017, In : Virology. 511, p. 30-39 10 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
HIV Infections
HIV-1
Jurkat Cells
Cytokines
35 Citations (Scopus)

Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strube, A., Gutman, M. J., Pedreno-Lopez, N., Grubaugh, N. D., Silveira, C. G. T., Maxwell, H. S., Domingues, A., Martins, M., Lee, D. E., Okwuazi, E. E., Jean, S. & 10 others, Strobert, E. A., Chahroudi, A., Silvestri, G., Vanderford, T. H., Kallas, E. G., Desrosiers, R. C., Bonaldo, M. C., Whitehead, S. S., Burton, D. R. & Watkins, D., Oct 4 2017, In : Science Translational Medicine. 9, 410, aan8184.

Research output: Contribution to journalArticle

Macaca
Neutralizing Antibodies
Monoclonal Antibodies
Antibody-Dependent Enhancement
Viremia
7 Citations (Scopus)

Potent plasmablast-derived antibodies elicited by the National Institutes of Health dengue vaccine

Magnani, D. M., Silveira, C. G. T., Ricciardi, M. J., Gonzalez-Nieto, L., Pedreño-Lopez, N., Bailey, V. K., Gutman, M. J., Maxwell, H. S., Domingues, A., Costa, P. R., Ferrari, L., Goulart, R., Martins, M., Martinez-Navio, J. M., Fuchs, S. P., Kalil, J., Timenetsky, M. D. C., Wrammert, J., Whitehead, S. S., Burton, D. R. & 3 others, Desrosiers, R. C., Kallas, E. G. & Watkins, D., Nov 1 2017, In : Journal of Virology. 91, 22, e00867-17.

Research output: Contribution to journalArticle

Dengue Vaccines
National Institutes of Health
Dengue virus
Dengue Virus
dengue
8 Citations (Scopus)

Protection against HIV acquisition in the RV144 trial

Desrosiers, R. C., Sep 1 2017, In : Journal of Virology. 91, 18, e00905-17.

Research output: Contribution to journalArticle

Vaccines
HIV
vaccines
5 Citations (Scopus)

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque

Martins, M., Tully, D. C., Shin, Y. C., Gonzalez-Nieto, L., Weisgrau, K. L., Bean, D. J., Gadgil, R., Gutman, M. J., Domingues, A., Maxwell, H. S., Magnani, D. M., Ricciardi, M., Pedreño-Lopez, N., Bailey, V., Cruz, M. A., Lima, N. S., Bonaldo, M. C., Altman, J. D., Rakasz, E., Capuano, S. & 6 others, Reimann, K. A., Piatak, M., Lifson, J. D., Desrosiers, R. C., Allen, T. M. & Watkins, D., Aug 1 2017, In : AIDS Research and Human Retroviruses. 33, 8, p. 843-858 16 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Infection Control
Macaca mulatta
T-Lymphocytes
Virus Replication
1 Citation (Scopus)

Simian T lymphotropic virus 1 Infection of Papio anubis: Tax sequence heterogeneity and T cell recognition

Termini, J. M., Magnani, D. M., Maxwell, H. S., Lauer, W., Castro, I., Pecotte, J., Barber, G. N., Watkins, D. & Desrosiers, R. C., Oct 1 2017, In : Journal of Virology. 91, 20, e00950-17.

Research output: Contribution to journalArticle

Simian T-lymphotropic virus 1
Primate T-lymphotropic virus 1
Papio anubis
Papio
taxes

Use of a gamma-2 herpesvirus as a vector to deliver antibodies to rhesus monkeys

Bischof, G. F., Shin, Y. C., Fuchs, S. P., Martinez-Navio, J. M., Lauer, W. A., Rakasz, E. G. & Desrosiers, R. C., Aug 1 2017, In : Gene Therapy. 24, 8, p. 487-492 6 p.

Research output: Contribution to journalArticle

Herpesviridae
Macaca mulatta
Rhadinovirus
Antibodies
Dependovirus
2 Citations (Scopus)

Use of a recombinant gamma-2 herpesvirus vaccine vector against dengue virus in rhesus monkeys

Bischof, G. F., Magnani, D. M., Ricciardi, M., Shin, Y. C., Domingues, A., Bailey, V. K., Gonzalez-Nieto, L., Rakasz, E. G., Watkins, D. & Desrosiers, R. C., Aug 1 2017, In : Journal of Virology. 91, 16, e00525-17.

Research output: Contribution to journalArticle

Herpesvirus Vaccines
vector vaccines
Dengue virus
Dengue Virus
Macaca mulatta
9 Citations (Scopus)

Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques

Martins, M., Shin, Y. C., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Castro, I., Magnani, D. M., Ricciardi, M., Pedreño-Lopez, N., Bailey, V., Betancourt, D., Altman, J. D., Pauthner, M., Burton, D. R., von Bredow, B., Evans, D. T., Yuan, M., Parks, C. L., Ejima, K. & 7 others, Allison, D. B., Rakasz, E., Barber, G. N., Capuano, S., Lifson, J. D., Desrosiers, R. C. & Watkins, D., Jul 1 2017, In : PLoS Pathogens. 13, 7, e1006529.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Replication
Macaca mulatta
AIDS Vaccines
Vaccines
2016
4 Citations (Scopus)

Cellular immune responses against simian T-lymphotropic virus type 1 target Tax in infected baboons

Castro, I., Giret, T. M., Magnani, D. M., Maxwell, H. S., Umland, O., Perry, J. K., Pecotte, J. K., Brasky, K. M., Barber, G. N., Desrosiers, R. C. & Watkins, D., Jun 1 2016, In : Journal of Virology. 90, 11, p. 5280-5291 12 p.

Research output: Contribution to journalArticle

Simian T-lymphotropic virus 1
Human T-lymphotropic virus 1
Papio
taxes
Cellular Immunity
4 Citations (Scopus)

Magnitude and quality of cytokine and chemokine storm during acute infection distinguish nonprogressive and progressive simian immunodeficiency virus infections of nonhuman primates

Keating, S. M., Heitman, J. W., Wu, S., Deng, X., Stacey, A. R., Zahn, R. C., de la Rosa, M., Finstad, S. L., Lifson, J. D., Piatak, M., Gauduin, M. C., Kessler, B. M., Ternette, N., Carville, A., Johnson, R. P., Desrosiers, R. C., Letvin, N. L., Borrow, P., Norris, P. J. & Schmitz, J. E., Jan 1 2016, In : Journal of Virology. 90, 22, p. 10339-10350 12 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Diseases
chemokines
Chemokines
35 Citations (Scopus)

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

Panico, M., Bouché, L., Binet, D., O'Connor, M. J., Rahman, D., Pang, P. C., Canis, K., North, S. J., Desrosiers, R. C., Chertova, E., Keele, B. F., Bess, J. W., Lifson, J. D., Haslam, S. M., Dell, A. & Morris, H. R., Sep 8 2016, In : Scientific Reports. 6, 32956.

Research output: Contribution to journalArticle

Neutralizing Antibodies
Glycosylation
Virion
HIV-1
Polysaccharides
15 Citations (Scopus)

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

Adnan, S., Reeves, R. K., Gillis, J., Wong, F. E., Yu, Y., Camp, J. V., Li, Q., Connole, M., Li, Y., Piatak, M., Lifson, J. D., Li, W., Keele, B. F., Kozlowski, P. A., Desrosiers, R. C., Haase, A. T. & Johnson, R. P., Dec 13 2016, In : PLoS Pathogens. 12, 12, e1006104.

Research output: Contribution to journalArticle

Immunity
Vaccination
Lymphoid Tissue
T-Lymphocytes
Cellular Immunity
28 Citations (Scopus)
Dependovirus
HIV
Virus Diseases
Antibodies
Haplorhini
9 Citations (Scopus)

Recombinant AAV vectors for enhanced expression of authentic IgG

Fuchs, S. P., Martinez-Navio, J. M., Gao, G. & Desrosiers, R. C., Jun 1 2016, In : PLoS One. 11, 6, e0158009.

Research output: Contribution to journalArticle

Dependovirus
immunoglobulin G
Viruses
Immunoglobulin G
Woodchuck hepatitis virus
2015
42 Citations (Scopus)

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

Fuchs, S. P., Martinez-Navio, J. M., Piatak, M., Lifson, J. D., Gao, G. & Desrosiers, R. C., Aug 1 2015, In : PLoS Pathogens. 11, 8, e1005090.

Research output: Contribution to journalArticle

Viral Load
Haplorhini
HIV Infections
Antibody Formation
HIV-1
164 Citations (Scopus)

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Gardner, M. R., Kattenhorn, L. M., Kondur, H. R., Von Schaewen, M., Dorfman, T., Chiang, J. J., Haworth, K. G., Decker, J. M., Alpert, M. D., Bailey, C. C., Neale, E. S., Fellinger, C. H., Joshi, V. R., Fuchs, S. P., Martinez-Navio, J. M., Quinlan, B. D., Yao, A. Y., Mouquet, H., Gorman, J., Zhang, B. & 14 others, Poignard, P., Nussenzweig, M. C., Burton, D. R., Kwong, P. D., Piatak, M., Lifson, J. D., Gao, G., Desrosiers, R. C., Evans, D. T., Hahn, B. H., Ploss, A., Cannon, P. M., Seaman, M. S. & Farzan, M., Mar 5 2015, In : Nature. 519, 7541, p. 87-91 5 p.

Research output: Contribution to journalArticle

Dependovirus
HIV-1
Neutralizing Antibodies
env Gene Products
AIDS Vaccines
17 Citations (Scopus)

Gp120 on HIV-1 virions lacks O-linked carbohydrate

Stansell, E., Panico, M., Canis, K., Pang, P. C., Bouché, L., Binet, D., O'Connor, M. J., Chertova, E., Bess, J., Lifson, J. D., Haslam, S. M., Morris, H. R., Desrosiers, R. C. & Dell, A., Apr 27 2015, In : PLoS One. 10, 4, e0124784.

Research output: Contribution to journalArticle

HIV Envelope Protein gp120
Threonine
Human immunodeficiency virus 1
virion
Virion
29 Citations (Scopus)

Host Anti-antibody Responses Following Adeno-associated Virus–mediated Delivery of Antibodies Against HIV and SIV in Rhesus Monkeys

Martinez-Navio, J. M., Fuchs, S. P., Pedreño-López, S., Rakasz, E. G., Gao, G. & Desrosiers, R. C., Oct 7 2015, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Macaca mulatta
Antibody Formation
Anti-Idiotypic Antibodies
HIV
23 Citations (Scopus)

Importance of codon usage for the temporal regulation of viral gene expression

Shin, Y. C., Bischof, G. F., Lauer, W. A. & Desrosiers, R. C., Nov 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 14030-14035 6 p.

Research output: Contribution to journalArticle

Viral Gene Expression Regulation
Codon
Glycoproteins
Rhadinovirus
Viruses
2014
16 Citations (Scopus)
EphA2 Receptor
Human herpesvirus 8
Ephrins
Human Herpesvirus 8
receptors
96 Citations (Scopus)

Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10

Yang, B., Li, S., Wang, H., Guo, Y., Gessler, D. J., Cao, C., Su, Q., Kramer, J., Zhong, L., Ahmed, S. S., Zhang, H., He, R., Desrosiers, R. C., Brown, R., Xu, Z. & Gao, G., 2014, In : Molecular Therapy. 22, 7, p. 1299-1309 11 p.

Research output: Contribution to journalArticle

Primates
Central Nervous System
Callithrix
Dependovirus
Blood-Brain Barrier
9 Citations (Scopus)

Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques

Yen, P. J., Mefford, M. E., Hoxie, J. A., Williams, K. C., Desrosiers, R. C. & Gabuzda, D., 2014, In : Virology. 458-459, 1, p. 53-68 16 p.

Research output: Contribution to journalArticle

Macaca
Glycoproteins
Macrophages
Infection
Brain
1 Citation (Scopus)

Localization of productively infected cells in the Spleen and Peyer's patches of rhesus macaques during acute infection with SIVmac239Δnef- enhanced green fluorescent protein

Yang, G. B., Alexander, L., Aye, P., Alvarez, X., Desrosiers, R. C. & Lackner, A. A., 2014, In : AIDS Research and Human Retroviruses. 30, 8, p. 738-739 2 p.

Research output: Contribution to journalArticle

Simian Acquired Immunodeficiency Syndrome
Peyer's Patches
Simian Immunodeficiency Virus
Green Fluorescent Proteins
Macaca mulatta

Reply to “on the use of 2,5-dimethyl-pyrrol-1-yl-benzoic acid derivatives as EPH-ephrin antagonists“

Desrosiers, R. C. & Hahn, A. S., 2014, In : Journal of Virology. 88, 20, p. 12174 1 p.

Research output: Contribution to journalArticle

EphA2 Receptor
Ephrins
Small Molecule Libraries
Human Herpesvirus 8
Benzoic Acid
18 Citations (Scopus)

SIV Vpx is essential for macrophage infection but not for development of AIDS

Westmoreland, S. V., Converse, A. P., Hrecka, K., Hurley, M., Knight, H., Piatak, M., Lifson, J., Mansfield, K. G., Skowronski, J. & Desrosiers, R. C., Jan 21 2014, In : PLoS One. 9, 1

Research output: Contribution to journalArticle

Macrophages
Acquired Immunodeficiency Syndrome
macrophages
Viruses
Infection
4 Citations (Scopus)

Systematic analysis of intracellular trafficking motifs located within the cytoplasmic domain of simian immunodeficiency virus glycoprotein gp41

Postler, T. S., Bixby, J. G., Desrosiers, R. C., Yuste, E. & Ambrose, Z., Dec 5 2014, In : PLoS One. 9, 12, e114753.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Viruses
virion
Virion
2013
46 Citations (Scopus)

Comparative characterization of transfection-and infection-derived simian immunodeficiency virus challenge stocks for In Vivo nonhuman primate studies

Del Prete, G. Q., Scarlotta, M., Newman, L., Reid, C., Parodi, L. M., Roser, J. D., Oswald, K., Marx, P. A., Miller, C. J., Desrosiers, R. C., Barouch, D. H., Pal, R., Piatak, M., Chertova, E., Giavedoni, L. D., O'Connor, D. H., Lifson, J. D. & Keele, B. F., Apr 2013, In : Journal of Virology. 87, 8, p. 4584-4595 12 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
transfection
Primates
Transfection
15 Citations (Scopus)

Influence of mismatch of env sequences on vaccine protection by live attenuated simian immunodeficiency virus

Manrique, J., Piatak, M., Lauer, W., Johnson, W., Mansfield, K., Lifson, J. & Desrosiers, R. C., Jul 2013, In : Journal of Virology. 87, 13, p. 7246-7254 9 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Attenuated Vaccines
monkeys
Immunity
5 Citations (Scopus)

Nonhuman lentiviruses

Evans, D. T., Elder, J. H. & Desrosiers, R. C., May 21 2013, Fields Virology: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lentivirus
19 Citations (Scopus)
Rhadinovirus
Eph Family Receptors
Macaca mulatta
B-Lymphocytes
Endothelial Cells