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  • Jay S Skyler
2020

A Wake-Up Call

Skyler, J. S., Feb 2020, In : Diabetes Technology and Therapeutics. 22, 2, 1 p.

Research output: Contribution to journalComment/debate

Foreword

Skyler, J. S., Jan 1 2020, Behavioral Diabetes: Social Ecological Perspectives for Pediatric and Adult Populations. Springer International Publishing, p. ix

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Low-dose empagliflozin as adjunct-to-insulin therapy in type 1 diabetes: A valid modelling and simulation analysis to confirm efficacy

Perkins, B. A., Soleymanlou, N., Rosenstock, J., Skyler, J. S., Laffel, L. M., Liesenfeld, K. H., Neubacher, D., Riggs, M. M., Johnston, C. K., Eudy-Byrne, R. J., Elmokadem, A., George, J. T., Marquard, J. & Nock, V., Mar 1 2020, In : Diabetes, Obesity and Metabolism. 22, 3, p. 427-433 7 p.

Research output: Contribution to journalArticle

Open Access

Practical recommendations for the management of diabetes in patients with COVID-19

Bornstein, S. R., Rubino, F., Khunti, K., Mingrone, G., Hopkins, D., Birkenfeld, A. L., Boehm, B., Amiel, S., Holt, R. IG., Skyler, J. S., DeVries, J. H., Renard, E., Eckel, R. H., Zimmet, P., Alberti, K. G., Vidal, J., Geloneze, B., Chan, J. C., Ji, L. & Ludwig, B., Jun 2020, In : The Lancet Diabetes and Endocrinology. 8, 6, p. 546-550 5 p.

Research output: Contribution to journalReview article

Open Access
69 Scopus citations
2019

An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes

Herold, K. C., Bundy, B. N., Alice Long, S., Bluestone, J. A., DiMeglio, L. A., Dufort, M. J., Gitelman, S. E., Gottlieb, P. A., Krischer, J. P., Linsley, P. S., Marks, J. B., Moore, W., Moran, A., Rodriguez, H., Russell, W. E., Schatz, D., Skyler, J. S., Tsalikian, E., Wherrett, D. K., Ziegler, A. G. & 1 others, Greenbaum, C. J., Aug 15 2019, In : New England Journal of Medicine. 381, 7, p. 603-613 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes

Type 1 Diabetes Trial Net and Diabetes Prevention Trial-Type-1 (DPT-1) Study Groups, Jun 2019, In : Pediatric Diabetes. 20, 4, p. 408-413 6 p.

Research output: Contribution to journalArticle

Bringing closure: towards achieving a better understanding of Israel

Rosenstock, J., Zimmet, P., Skyler, J. S., Atkinson, M., Schatz, D., Buse, J. B., Kahn, S., Hirsch, I. B., Leroith, D. & Alberti, K. G., Aug 17 2019, In : The Lancet. 394, 10198, 1 p.

Research output: Contribution to journalLetter

Open Access
1 Scopus citations

Exploring patient preferences for adjunct-to-insulin therapy in type 1 diabetes

Perkins, B. A., Rosenstock, J., Skyler, J. S., Laffel, L. M., Cherney, D. Z., Mathieu, C., Pang, C., Wood, R., Kinduryte, O., George, J. T., Marquard, J. & Soleymanlou, N., Sep 1 2019, In : Diabetes care. 42, 9, p. 1716-1723 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Imagining a better future for all people with type 1 diabetes mellitus

Korsgren, O., Skyler, J. S., Skog, O., Sundberg, F., Forsander, G. & Ludvigsson, J., Jan 1 2019, (Accepted/In press) In : Nature Reviews Endocrinology.

Research output: Contribution to journalComment/debate

1 Scopus citations

International consensus on risk management of diabetic ketoacidosis in patients with type 1 diabetes treated with sodium-glucose cotransporter (SGLT) inhibitors

Danne, T., Garg, S., Peters, A. L., Buse, J. B., Mathieu, C., Pettus, J. H., Alexander, C. M., Battelino, T., Ampudia-Blasco, F. J., Bode, B. W., Cariou, B., Close, K. L., Dandona, P., Dutta, S., Ferrannini, E., Fourlanos, S., Grunberger, G., Heller, S. R., Henry, R. R., Kurian, M. J. & 10 others, Kushner, J. A., Oron, T., Parkin, C. G., Pieber, T. R., Rodbard, H. W., Schatz, D., Skyler, J. S., Tamborlane, W. V., Yokote, K. & Phillip, M., 2019, In : Diabetes care. 42, 6, p. 1147-1154 8 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Low-dose anti-thymocyte globulin preserves C-peptide, reduces HbA1c, and increases regulatory to conventional T-cell ratios in new-onset type 1 diabetes: Two-year clinical trial data

Type 1 Diabetes TrialNet ATG-GCSF Study Group, Jun 1 2019, In : Diabetes. 68, 6, p. 1267-1276 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

Vecchio, F., Lo Buono, N., Stabilini, A., Nigi, L., Dufort, M. J., Geyer, S., Rancoita, P. M., Cugnata, F., Mandelli, A., Valle, A., Leete, P., Mancarella, F., Linsley, P. S., Krogvold, L., Herold, K. C., Larsson, H. E., Richardson, S. J., Morgan, N. G., Dahl-Jørgensen, K., Sebastiani, G. & 82 others, Dotta, F., Bosi, E., Bianconi, E., Bonfanti, R., Bonura, C., De Pellegrin, M., Frontino, G., Grogan, P., Laurenzi, A., Meschi, F., Ragogna, F., Rigamonti, A., Greenbaum, C. J., Atkinson, M., Baidal, D., Becker, D., Bingley, P., Buckner, J., Clements, M., Colman, P., DiMeglio, L., Gitelman, S., Goland, R., Gottlieb, P., Knip, M., Krischer, J., Lernmark, A., Moore, W., Moran, A., Muir, A., Palmer, J., Peakman, M., Philipson, L., Raskin, P., Redondo, M., Rodriguez, H., Russell, W., Spain, L., Schatz, D. A., Sosenko, J., Wentworth, J., Wherrett, D., Wilson, D., Winter, W., Ziegler, A., Anderson, M., Antinozzi, P., Benoist, C., Blum, J., Bourcier, K., Chase, P., Clare-Salzler, M., Clynes, R., Eisenbarth, G., Fathman, C. G., Grave, G., Hering, B., Insel, R., Kaufman, F., Kay, T., Leschek, E., Mahon, J., Marks, J. B., Nanto-Salonen, K., Nepom, G., Orban, T., Parkman, R., Pescovitz, M., Peyman, J., Pugliese, A., Roep, B., Roncarolo, M., Savage, P., Simell, O., Sherwin, R., Siegelman, M., Skyler, J. S., Steck, A., Thomas, J., Trucco, M., Wagner, J. & Battaglia, M., Sep 20 2018, In : JCI Insight. 3, 18, e122146.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Brief commentary: Confusing treatment guidelines for patients with type 2 diabetes

Hirsch, I. B. & Skyler, J. S., Aug 21 2018, In : Annals of Internal Medicine. 169, 4, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Cardiovascular outcomes trials in type 2 diabetes: Where Do We Go From Here? Ref lections From a Diabetes Care Editors' Expert Forum

Cefalu, W. T., Kaul, S., Gerstein, H. C., Holman, R. R., Zinman, B., Skyler, J. S., Green, J. B., Buse, J. B., Inzucchi, S. E., Leiter, L. A., Raz, I., Rosenstock, J. & Riddle, M. C., Jan 1 2018, In : Diabetes care. 41, 1, p. 14-31 18 p.

Research output: Contribution to journalArticle

149 Scopus citations

Empagliflozin as adjunctive to insulin therapyin type 1 diabetes: The EASE trials

Rosenstock, J., Marquard, J., Laffel, L. M., Neubacher, D., Kaspers, S., Cherney, D. Z., Zinman, B., Skyler, J. S., George, J., Soleymanlou, N. & Perkins, B. A., Dec 1 2018, In : Diabetes Care. 41, 12, p. 2560-2569 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

In Response to Carter and Heinemann: Insulin Concentration in Vials Randomly Purchased in Pharmacies in the United States: Considerable Loss in the Cold Supply Chain

Petersen, M. P., Hirsch, I. B., Skyler, J. S., Ostlund, R. E. & Cefalu, W. T., Jul 1 2018, In : Journal of Diabetes Science and Technology. 12, 4, p. 890-891 2 p.

Research output: Contribution to journalLetter

9 Scopus citations

Insulin sensitivity and blood pressure

Skyler, J. S., Marks, J. B., Thompson, N. E., Fili, M. D. & Schneiderman, N., Jan 1 2018, Stress and Disease Processes: Perspectives in Behavioral Medicine. Taylor and Francis, p. 197-223 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Low-dose anti-thymocyte globulin (ATG) preserves β-cell function and improves HbA1c in new-onset type 1 diabetes

Haller, M. J., Schatz, D. A., Skyler, J. S., Krischer, J. P., Bundy, B. N., Miller, J. L., Atkinson, M. A., Becker, D. J., Baidal, D., DiMeglio, L. A., Gitelman, S. E., Goland, R., Gottlieb, P. A., Herold, K. C., Marks, J. B., Moran, A., Rodriguez, H., Russell, W., Wilson, D. M. & Greenbaum, C. J., Sep 1 2018, In : Diabetes care. 41, 9, p. 1917-1925 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Sleeping oxygen saturation, rapid eye movement sleep, and the adaptation of postprandial metabolic function in insulin sensitive and resistant individuals without diabetes

Garcia, K. A., Wohlgemuth, W. K., Ferrannini, E., Mari, A., Gonzalez, A., Mendez, A. J., Bizzotto, R., Skyler, J. S., Schneiderman, N. & Hurwitz, B., Jul 1 2018, In : Physiology and Behavior. 191, p. 123-130 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1

Sosenko, J. M., Geyer, S., Skyler, J. S., Rafkin, L. E., Ismail, H. M., Libman, I. M., Liu, Y. F., DiMeglio, L. A., Evans-Molina, C. & Palmer, J. P., May 2018, In : Pediatric Diabetes. 19, 3, p. 403-409 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

The shape of the glucose concentration curve during an oral glucose tolerance test predicts risk for type 1 diabetes

Type 1 Diabetes TrialNet Study Group, Jan 1 2018, In : Diabetologia. 61, 1, p. 84-92 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Diabetes research and care through the ages

Zinman, B., Skyler, J. S., Riddle, M. C. & Ferrannini, E., Oct 1 2017, In : Diabetes Care. 40, 10, p. 1302-1313 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Differentiation of diabetes by pathophysiology, natural history, and prognosis

Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop, P. H., Handelsman, Y., Insel, R. A., Mathieu, C., McElvaine, A. T., Palmer, J. P., Pugliese, A., Schatz, D. A., Sosenko, J. M., Wilding, J. P. H. & Ratner, R. E., Feb 1 2017, In : Diabetes. 66, 2, p. 241-255 15 p.

Research output: Contribution to journalReview article

125 Scopus citations

Dysglycemia and Index60 as prediagnostic end points for type 1 diabetes prevention trials

Nathan, B. M., Boulware, D., Geyer, S., Atkinson, M. A., Colman, P., Goland, R., Russell, W., Wentworth, J. M., Wilson, D. M., Evans-Molina, C., Wherrett, D., Skyler, J. S., Moran, A. & Sosenko, J. M., Nov 1 2017, In : Diabetes care. 40, 11, p. 1494-1499 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Hope vs hype: where are we in type 1 diabetes?

Skyler, J. S., Dec 23 2017, (Accepted/In press) In : Diabetologia. p. 1-8 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Neurovascular uncoupling after rapid glycemic control as a trigger of the diabetic-uremic striatopallidal syndrome

Lizarraga, K. J., Adams, D., Judith Post, M., Skyler, J. S. & Singer, C., 2017, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

1 Scopus citations

The Use of Electrochemiluminescence Assays to Predict Autoantibody and Glycemic Progression Toward Type 1 Diabetes in Individuals with Single Autoantibodies

Sosenko, J. M., Yu, L., Skyler, J. S., Krischer, J. P., Gottlieb, P. A., Boulware, D., Miao, D., Palmer, J. P. & Steck, A. K., Mar 1 2017, In : Diabetes Technology and Therapeutics. 19, 3, p. 183-187 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus

Doran, T. M., Morimoto, J., Simanski, S., Koesema, E. J., Clark, L. F., Pels, K., Stoops, S. L., Pugliese, A., Skyler, J. S. & Kodadek, T., May 19 2016, In : Cell Chemical Biology. 23, 5, p. 618-628 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin

Pettus, J., Mcnabb, B., Eckel, R. H., Skyler, J. S., Dhalla, A., Guan, S., Jochelson, P., Belardinelli, L. & Henry, R. H., May 1 2016, In : Diabetes, Obesity and Metabolism. 18, 5, p. 463-474 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Adaptation of β-cell and endothelial function to carbohydrate loading: Influence of insulin resistance

Hurwitz, B., Schneiderman, N., Marks, J. B., Mendez, A. J., Gonzalez, A., Llabre, M., Smith, S. R., Bizzotto, R., Santini, E., Manca, M. L., Skyler, J. S., Mari, A. & Ferrannini, E., Jul 1 2015, In : Diabetes. 64, 7, p. 2550-2559 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Allogeneic mesenchymal precursor cells in type 2 diabetes: A randomized, placebo-controlled, dose-escalation safety and tolerability pilot study

Skyler, J. S., Fonseca, V. A., Segal, K. R. & Rosenstock, J., Sep 2015, In : Diabetes care. 38, 9, p. 1742-1749 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history

Sosenko, J. M., Skyler, J. S., Dimeglio, L. A., Beam, C. A., Krischer, J. P., Greenbaum, C. J., Boulware, D., Rafkin, L. E., Matheson, D., Herold, K. C., Mahon, J. & Palmer, J. P., Feb 1 2015, In : Diabetes care. 38, 2, p. 271-276 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Effect of docosahexaenoic acid supplementation on inflammatory cytokine levels in infants at high genetic risk for type 1 diabetes

The Type 1 Diabetes TrialNet Nutritional Intervention to Prevent (NIP) Type 1 Diabetes Study Group, Jun 1 2015, In : Pediatric Diabetes. 16, 4, p. 271-279 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Effect of ranolazine monotherapy on glycemic control in subjects with type 2 diabetes

Eckel, R. H., Henry, R. R., Yue, P., Dhalla, A., Wong, P., Jochelson, P., Belardinelli, L. & Skyler, J. S., Jul 2015, In : Diabetes care. 38, 7, p. 1189-1196 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Immune therapy for treating type 1 diabetes: Challenging existing paradigms

Skyler, J. S., Jan 2 2015, In : Journal of Clinical Investigation. 125, 1, p. 94-96 3 p.

Research output: Contribution to journalReview article

5 Scopus citations

Prevention and reversal of type 1 diabetes--past challenges and future opportunities

Skyler, J. S., Jun 1 2015, In : Diabetes Care. 38, 6, p. 997-1007 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Staging presymptomatic type 1 diabetes: A scientific statement of jdrf, the endocrine society, and the American diabetes association

Insel, R. A., Dunne, J. L., Atkinson, M. A., Chiang, J. L., Dabelea, D., Gottlieb, P. A., Greenbaum, C. J., Herold, K. C., Krischer, J. P., Lernmark, A., Ratner, R. E., Rewers, M. J., Schatz, D. A., Skyler, J. S., Sosenko, J. M. & Ziegler, A. G., Oct 2015, In : Diabetes care. 38, 10, p. 1964-1974 11 p.

Research output: Contribution to journalArticle

239 Scopus citations

Subcutaneous injection of hyaluronidase with recombinant human insulin compared with insulin lispro in type 1 diabetes

Garg, S. K., Buse, J. B., Skyler, J. S., Vaughn, D. E. & Muchmore, D. B., Feb 1 2015, In : Diabetes Technology and Therapeutics. 17, p. S45-S46

Research output: Contribution to journalArticle

T1DM in 2014: Progress towards a bionic pancreas

Skyler, J. S., Jan 1 2015, In : Nature Reviews Gastroenterology and Hepatology. 12, 1, p. 31-32 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

The Development, Validation, and Utility of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS)

Sosenko, J. M., Skyler, J. S. & Palmer, J. P., Aug 18 2015, In : Current Diabetes Reports. 15, 8, 49.

Research output: Contribution to journalArticle

2 Scopus citations

The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months

Sosenko, J. M., Skyler, J. S., Beam, C. A., Boulware, D., Mahon, J. L., Krischer, J. P., Greenbaum, C. J., Rafkin, L. E., Matheson, D., Herold, K. C. & Palmer, J. P., May 2015, In : Diabetes care. 38, 5, p. 940-942 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Toward primary prevention of type 1 diabetes

Skyler, J. S., Apr 21 2015, In : JAMA - Journal of the American Medical Association. 313, 15, p. 1520-1521 2 p.

Research output: Contribution to journalArticle

8 Scopus citations

Type 1 diabetes at a crossroads

Cefalu, W. T., Tamborlane, W. V. & Skyler, J. S., Jun 2015, In : Diabetes care. 38, 6, p. 968-970 3 p.

Research output: Contribution to journalEditorial

10 Scopus citations
2014

B-lymphocyte depletion with rituximab and β-cell function: Two-year results

Pescovitz, M. D., Greenbaum, C. J., Bundy, B., Becker, D. J., Gitelman, S. E., Goland, R., Gottlieb, P. A., Marks, J. B., Moran, A., Raskin, P., Rodriguez, H., Schatz, D. A., Wherrett, D. K., Wilson, D. M., Krischer, J. P. & Skyler, J. S., Feb 1 2014, In : Diabetes care. 37, 2, p. 453-459 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Characterizing subgroups of type 1 diabetes

Skyler, J. S., Nov 1 2014, In : Diabetes. 63, 11, p. 3578-3580 3 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: Follow-up 1 year aftercessation of treatment

Orban, T., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Gottlieb, P. A., Greenbaum, C. J., Marks, J. B., Monzavi, R., Moran, A., Peakman, M., Raskin, P., Russell, W. E., Schatz, D., Wherrett, D. K., Wilson, D. M., Krischer, J. P. & Skyler, J. S., Apr 2014, In : Diabetes care. 37, 4, p. 1069-1075 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

Interleukin-1 antagonism in type 1 diabetes of recent onset: Two multicenter, randomized double-masked, placebo-controlled trials

Moran, A., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Greenbaum, C. J., Herold, K. C., Marks, J. B., Raskin, P., Sanda, S., Schatz, D., Wherrett, D., Wilson, D. M., Krischer, J. P., Skyler, J. S., Pickersgill, L., De Koning, E., Ziegler, A. G., Böehm, B. & 11 others, Badenhoop, K., Schloot, N., Bak, J. F., Pozzilli, P., Mauricio, D., Donath, M. Y., Castaño, L., Wägner, A., Lervang, H. H., Perrild, H. & Mandrup-Poulsen, T., 2014, In : Diabetes Technology and Therapeutics. 16, SUPPL. 1, p. S87

Research output: Contribution to journalComment/debate

Options for prandial glucose management in type 2 diabetes patients using basal insulin: Addition of a short-acting GLP-1 analogue versus progression to basal-bolus therapy

Hirsch, I. B., Buse, J. B., Leahy, J., Mcgill, J. B., Peters, A., Rodbard, H. W., Rubin, R. R., Skyler, J. S., Verderese, C. A. & Riddle, M. C., Mar 2014, In : Diabetes, Obesity and Metabolism. 16, 3, p. 206-214 9 p.

Research output: Contribution to journalReview article

7 Scopus citations

Struggles with clinical translation of immune intervention trials

Skyler, J. S., May 2014, In : Diabetes care. 37, 5, p. 1173-1175 3 p.

Research output: Contribution to journalComment/debate

3 Scopus citations