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  • Ashok Saluja
2016

Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells

Nomura, A., Dauer, P., Gupta, V., McGinn, O., Arora, N., Majumdar, K., Uhlrich, C., Dalluge, J., Dudeja, V., Saluja, A. & Banerjee, S., Jan 1 2016, In : Oncotarget. 7, 35, p. 56324-56337 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Minnelide Overcomes Oxaliplatin Resistance by Downregulating the DNA Repair Pathway in Pancreatic Cancer

Modi, S., Kir, D., Giri, B., Majumder, K., Arora, N., Dudeja, V., Banerjee, S. & Saluja, A., Jan 1 2016, In : Journal of Gastrointestinal Surgery. 20, 1, p. 13-24 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Minutes of the Business Meeting of the American Pancreatic Association, Friday, November 6, 2015, San Diego, California

Maitra, A., Fernández-Del Castillo, C., Pandol, S. J., Saluja, A., Conwell, D. L., Sahin-Tóth, M., Tempero, M. A. & Go, V. L. W., Nov 1 2016, In : Pancreas. 45, 10, p. 1376-1377 2 p.

Research output: Contribution to journalShort survey

Mutational and transcriptome based sub-classification of pancreatic cancer: Are we there yet?

Sethi, V., Garg, B., Saluja, A. & Dudeja, V., Jan 1 2016, In : Translational Cancer Research. 5, p. S395-S399

Research output: Contribution to journalEditorial

Release of Cathepsin B in Cytosol Causes Cell Death in Acute Pancreatitis

Talukdar, R., Sareen, A., Zhu, H., Yuan, Z., Dixit, A., Cheema, H., George, J., Barlass, U., Sah, R., Garg, S. K., Banerjee, S., Garg, P., Dudeja, V., Dawra, R. & Saluja, A., Oct 1 2016, In : Gastroenterology. 151, 4, p. 747-758.e5

Research output: Contribution to journalArticle

28 Scopus citations
2015

CD133 initiates tumors, induces epithelial-mesenchymal transition and increases metastasis in pancreatic cancer

Nomura, A., Banerjee, S., Chugh, R., Dudeja, V., Yamamoto, M., Vickers, S. M. & Saluja, A., Jan 1 2015, In : Oncotarget. 6, 10, p. 8313-8322 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Minnelide, a novel drug for pancreatic and liver cancer

Banerjee, S. & Saluja, A., Jul 1 2015, In : Pancreatology. 15, 4

Research output: Contribution to journalArticle

17 Scopus citations

Minnelide effectively eliminates CD133+ side population in pancreatic cancer

Nomura, A., McGinn, O., Dudeja, V., Sangwan, V., Saluja, A. & Banerjee, S., Nov 23 2015, In : Molecular Cancer. 14, 1, 200.

Research output: Contribution to journalArticle

13 Scopus citations

Minutes of the business meeting of the American pancreatic association, Friday, November 7, 2014, Kohala Coast, Hawaii

Pandol, S. J., Maitra, A., Freeman, M. L., Saluja, A., Conwell, D. L., Castillo, C. F. D., Sahin-Tóth, M. & Go, V. L. W., Jan 1 2015, In : Pancreas. 44, 8, p. 1176-1177 2 p.

Research output: Contribution to journalArticle

Neutrophil Extracellular Traps Provide a Grip on the Enigmatic Pathogenesis of Acute Pancreatitis

Korhonen, J. T., Dudeja, V., Dawra, R., Kubes, P. & Saluja, A., Dec 1 2015, In : Gastroenterology. 149, 7, p. 1682-1685 4 p.

Research output: Contribution to journalReview article

3 Scopus citations

Primary and liver metastasis-derived cell lines from Kras G12D; Trp53 R172H; Pdx-1 cre animals undergo apoptosis in response to triptolide

Sangwan, V., Banerjee, S., Jensen, K. M., Chen, Z., Chugh, R., Dudeja, V., Vickers, S. M. & Saluja, A., Jan 1 2015, In : Pancreas. 44, 4, p. 583-589 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia

Ganguly, S., Home, T., Yacoub, A., Kambhampati, S., Shi, H., Dandawate, P., Padhye, S., Saluja, A., McGuirk, J. & Rao, R., Jan 1 2015, In : Oncotarget. 6, 31, p. 31767-31779 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F

Oliveira, A. R., Beyer, G., Chugh, R., Skube, S. J., Majumder, K., Banerjee, S., Sangwan, V., Li, L., Dawra, R., Subramanian, S., Saluja, A. & Dudeja, V., Jan 1 2015, In : Laboratory Investigation. 95, 6, p. 648-659 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma

Jacobson, B. A., Chen, E. Z., Tang, S., Belgum, H. S., McCauley, J. A., Evenson, K. A., Etchison, R. G., Jay-Dixon, J., Patel, M. R., Raza, A., Saluja, A., D’Cunha, J. & Kratzke, R. A., Jan 1 2015, In : Genes and Cancer. 6, 3-4, p. 144-152 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma

Brincks, E. L., Kucaba, T. A., James, B. R., Murphy, K. A., Schwertfeger, K. L., Sangwan, V., Banerjee, S., Saluja, A. & Griffith, T. S., Dec 1 2015, In : FEBS Journal. 282, 24, p. 4747-4765 19 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

CD133+ tumor initiating cells in a syngenic murine model of pancreatic cancer respond to minnelide

Banerjee, S., Nomura, A., Sangwan, V., Chugh, R., Dudeja, V., Vickers, S. M. & Saluja, A., May 1 2014, In : Clinical Cancer Research. 20, 9, p. 2388-2399 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Endoplasmic reticulum stress is chronically activated in chronic pancreatitis

Sah, R. P., Garg, S. K., Dixit, A. K., Dudeja, V., Dawra, R. & Saluja, A., Oct 3 2014, In : Journal of Biological Chemistry. 289, 40, p. 27551-27561 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug

Rivard, C., Geller, M., Schnettler, E., Saluja, M., Vogel, R. I., Saluja, A. & Ramakrishnan, S., Nov 1 2014, In : Gynecologic Oncology. 135, 2, p. 318-324 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Minutes of the business meeting of the American Pancreatic Association, Friday, November 1, 2013, Miami, Florida

Freeman, M., Pandol, S. J., Liddle, R. A., Saluja, A., Fernandez-Del Castillo, C., Maitra, A., Sahin-Toth, M. & Go, V. L. W., Nov 10 2014, In : Pancreas. 43, 8, p. 1141-1142 2 p.

Research output: Contribution to journalArticle

Sorafenib and triptolide as combination therapy for hepatocellular carcinoma

Alsaied, O. A., Sangwan, V., Banerjee, S., Krosch, T. C., Chugh, R., Saluja, A., Vickers, S. M. & Jensen, E. H., Jan 1 2014, In : Surgery (United States). 156, 2, p. 270-279 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells

Mujumdar, N., Banerjee, S., Chen, Z., Sangwan, V., Chugh, R., Dudeja, V., Yamamoto, M., Vickers, S. M. & Saluja, A., Jun 1 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 11

Research output: Contribution to journalArticle

30 Scopus citations

Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathway

Chen, Z., Sangwan, V., Banerjee, S., Chugh, R., Dudeja, V., Vickers, S. M. & Saluja, A., Jan 1 2014, In : Cancer Letters. 348, 1-2, p. 156-166 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Wild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma

Caicedo-Granados, E., Lin, R., Fujisawa, C., Yueh, B., Sangwan, V. & Saluja, A., Jan 1 2014, In : Oral Oncology. 50, 12, p. 1149-1156 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Advances in acute and chronic pancreatitis: From development to inflammation and repair

Pasca Di Magliano, M., Forsmark, C., Freedman, S., Hebrok, M., Pasricha, P. J., Saluja, A., Stanger, B. Z., Holt, J., Serrano, J., James, S. P. & Rustgi, A. K., Jan 1 2013, In : Gastroenterology. 144, 1

Research output: Contribution to journalArticle

11 Scopus citations

American pancreatic association: 2013 vay liang and frisca go award for lifetime achievement and distinguished service award

Saluja, A., Brudvik, E. A., Carney, J. B. & Go, V. L. W., Nov 1 2013, In : Pancreas. 42, 8, p. 1203-1206 4 p.

Research output: Contribution to journalEditorial

7 Scopus citations
51 Scopus citations
Open Access

Minnelide: A Novel Therapeutic That Promotes Apoptosis in Non-Small Cell Lung Carcinoma In Vivo

Rousalova, I., Banerjee, S., Sangwan, V., Evenson, K., McCauley, J. A., Kratzke, R., Vickers, S. M., Saluja, A. & D'Cunha, J., Oct 15 2013, In : PLoS One. 8, 10, e77411.

Research output: Contribution to journalArticle

33 Scopus citations

Minnelide reduces tumor burden in preclinical models of osteosarcoma

Banerjee, S., Thayanithy, V., Sangwan, V., Mackenzie, T. N., Saluja, A. & Subramanian, S., Jul 28 2013, In : Cancer Letters. 335, 2, p. 412-420 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Minutes of the business meeting of the American Pancreatic Association, Friday, November 2, 2012, Miami, Florida.

Liddle, R. A., Freeman, M., Simeone, D. M., Saluja, A., Castillo, C. F. D., Maitra, A., Pandol, S. J. & Go, V. L. W., Nov 1 2013, In : Pancreas. 42, 8, p. 1333-1334 2 p.

Research output: Contribution to journalArticle

MiR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death

Chen, Z., Sangwan, V., Banerjee, S., Mackenzie, T., Dudeja, V., Li, X., Wang, H., Vickers, S. M. & Saluja, A., Sep 11 2013, In : Molecular Cancer. 12, 1, 105.

Research output: Contribution to journalArticle

46 Scopus citations

New insights into the pathogenesis of pancreatitis

Sah, R. P., Dawra, R. & Saluja, A., Sep 1 2013, In : Current Opinion in Gastroenterology. 29, 5, p. 523-530 8 p.

Research output: Contribution to journalReview article

105 Scopus citations

Relevance of animal models of pancreatic cancer and pancreatitis to human disease

Saluja, A. & Dudeja, V., Jan 1 2013, In : Gastroenterology. 144, 6, p. 1194-1198 5 p.

Research output: Contribution to journalComment/debate

29 Scopus citations

Triptolide-induced cell death in Pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1

Banerjee, S., Sangwan, V., McGinn, O., Chugh, R., Dudeja, V., Vickers, S. M. & Saluja, A., Nov 22 2013, In : Journal of Biological Chemistry. 288, 47, p. 33927-33938 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Triptolide induces the expression of miR-142-3p: A negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation

MacKenzie, T. N., Mujumdar, N., Banerjee, S., Sangwan, V., Sarver, A., Vickers, S., Subramanian, S. & Saluja, A., Jul 1 2013, In : Molecular Cancer Therapeutics. 12, 7, p. 1266-1275 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity

Krosch, T. C. K., Sangwan, V., Banerjee, S., Mujumdar, N., Dudeja, V., Saluja, A. & Vickers, S. M., Apr 1 2013, In : American Journal of Surgery. 205, 4, p. 387-396 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

2012 international association of pancreatology presidential address: A time for change

Saluja, A., Nov 1 2012, In : Pancreas. 41, 8, 1 p.

Research output: Contribution to journalEditorial

American pancreatic association: The vay liang and frisca go award for lifetime achievement

Go, V. L. W., Yee, S., Brudvik, E. A. & Saluja, A., Nov 1 2012, In : Pancreas. 41, 8, p. 1168-1175 8 p.

Research output: Contribution to journalEditorial

4 Scopus citations

A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer

Chugh, R., Sangwan, V., Patil, S. P., Dudeja, V., Dawra, R., Banerjee, S., Schumacher, R. J., Blazar, B. R., Georg, G. I., Vickers, S. M. & Saluja, A., Oct 17 2012, In : Science Translational Medicine. 4, 156, 156ra139.

Research output: Contribution to journalArticle

156 Scopus citations

Mechanism of action of the anti-cancer agent, triptolide

Sangwan, V. & Saluja, A., Dec 1 2012, Nutraceuticals and Cancer. Springer Netherlands, Vol. 9789400726307. p. 135-150 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization

Banerjee, S., Mujumdar, N., Dudeja, V., Mackenzie, T., Krosch, T. K., Sangwan, V., Vickers, S. M. & Saluja, A., Aug 13 2012, In : PLoS One. 7, 8, e43020.

Research output: Contribution to journalArticle

14 Scopus citations

Pathogenic mechanisms of acute pancreatitis

Sah, R. P., Garg, P. & Saluja, A., Sep 1 2012, In : Current Opinion in Gastroenterology. 28, 5, p. 507-515 9 p.

Research output: Contribution to journalReview article

85 Scopus citations
2011

Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: Benefits of α-1 antitrypsin treatment

Loganathan, G., Dawra, R., Pugazhenthi, S., Guo, Z., Soltani, S. M., Wiseman, A., Sanders, M. A., Papas, K. K., Velayutham, K., Saluja, A., Sutherland, D. E. R., Hering, B. J. & Balamurugan, A. N., Dec 15 2011, In : Transplantation. 92, 11, p. 1222-1230 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis

Dawra, R., Sah, R. P., Dudeja, V., Rishi, L., Talukdar, R., Garg, P. & Saluja, A., Jan 1 2011, In : Gastroenterology. 141, 6

Research output: Contribution to journalArticle

126 Scopus citations

Message from the president: The future of IAP

Saluja, A., Jan 1 2011, In : Pancreatology. 11, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorial

Molecular mechanisms of pancreatic injury

Sah, R. P. & Saluja, A., Sep 1 2011, In : Current Opinion in Gastroenterology. 27, 5, p. 444-451 8 p.

Research output: Contribution to journalReview article

61 Scopus citations

Molecular targeted approaches for treatment of pancreatic cancer

Huang, Z. Q., Saluja, A., Dudeja, V., Vickers, S. M. & Buchsbaum, D. J., Jul 1 2011, In : Current Pharmaceutical Design. 17, 21, p. 2221-2238 18 p.

Research output: Contribution to journalReview article

17 Scopus citations

Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway

Phillips, P. A., Sangwan, V., Borja-Cacho, D., Dudeja, V., Vickers, S. M. & Saluja, A., Sep 28 2011, In : Cancer Letters. 308, 2, p. 181-188 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors

Dudeja, V., Chugh, R. K., Sangwan, V., Skube, S. J., Mujumdar, N. R., Antonoff, M. B., Dawra, R., Vickers, S. M. & Saluja, A., Jun 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6

Research output: Contribution to journalArticle

40 Scopus citations

Trypsinogen activation in acute and chronic pancreatitis: Is it a prerequisite?

Sah, R. P. & Saluja, A., Oct 1 2011, In : Gut. 60, 10, p. 1305-1307 3 p.

Research output: Contribution to journalComment/debate

12 Scopus citations