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  • Carlos T Moraes
2013

Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy

Noe, N., Dillon, L., Lellek, V., Diaz, F., Hida, A., Moraes, C. T. & Wenz, T., Sep 1 2013, In : Mitochondrion. 13, 5, p. 417-426 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Mitochondrial alterations during carcinogenesis. A review of metabolic transformation and targets for anticancer treatments

Wang, X., Peralta, S. & Moraes, C. T., Jul 26 2013, In : Advances in Cancer Research. 119, p. 127-160 34 p.

Research output: Contribution to journalArticle

26 Scopus citations

Mitochondrial DNA damage in a mouse model of alzheimer's disease decreases amyloid beta plaque formation

Pinto, M., Pickrell, A. M., Fukui, H. & Moraes, C. T., Oct 1 2013, In : Neurobiology of Aging. 34, 10, p. 2399-2407 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mouse models of Parkinson's disease associated with mitochondrial dysfunction

Pickrell, A. M., Pinto, M. & Moraes, C. T., Jul 1 2013, In : Molecular and Cellular Neuroscience. 55, p. 87-94 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Nitric oxide synthesis is increased in cybrid cells with m.3243A>G mutation

Gamba, J., Gamba, L. T., Rodrigues, G. S., Kiyomoto, B. H., Moraes, C. T. & Tengan, C. H., Jan 1 2013, In : International Journal of Molecular Sciences. 14, 1, p. 394-410 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

Pohjoismäki, J. L. O., Williams, S. L., Boettger, T., Goffart, S., Kim, J., Suomalainen, A., Moraes, C. T. & Braun, T., Nov 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19408-19413 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Somatic mtDNA Mutation Spectra in the Aging Human Putamen

Williams, S. L., Mash, D. C., Zuchner, S. L. & Moraes, C. T., Dec 1 2013, In : PLoS Genetics. 9, 12, e1003990.

Research output: Contribution to journalArticle

46 Scopus citations

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

Bacman, S. R., Williams, S. L., Pinto, M., Peralta, S. & Moraes, C. T., Sep 1 2013, In : Nature Medicine. 19, 9, p. 1111-1113 3 p.

Research output: Contribution to journalArticle

178 Scopus citations

Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool

Wang, X., Pickrell, A. M., Rossi, S. G., Pinto, M., Dillon, L. M., Hida, A., Rotundo, R. L. & Moraes, C. T., Oct 1 2013, In : Human Molecular Genetics. 22, 19, p. 3976-3986 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Translational research in primary mitochondrial diseases: Challenges and opportunities

Moraes, C. T., Anderson, V. & Mohan, C., Nov 1 2013, In : Mitochondrion. 13, 6, p. 945-952 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2012

A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions

Diaz, F., Garcia, S., Padgett, K. & Moraes, C. T., Dec 1 2012, In : Human Molecular Genetics. 21, 23, p. 5066-5077 12 p., dds350.

Research output: Contribution to journalArticle

46 Scopus citations
63 Scopus citations

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., Diaz, F., Meijer, D., Suter, U., Hamprecht, B., Sereda, M. W., Moraes, C. T., Frahm, J., Goebbels, S. & Nave, K. A., May 24 2012, In : Nature. 485, 7399, p. 517-521 5 p.

Research output: Contribution to journalArticle

581 Scopus citations

Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse

Dillon, L. M., Williams, S. L., Hida, A., Peacock, J. D., Prolla, T. A., Lincoln, J. & Moraes, C. T., May 1 2012, In : Human Molecular Genetics. 21, 10, p. 2288-2297 10 p., dds049.

Research output: Contribution to journalArticle

51 Scopus citations

Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia

Wang, X., Pickrell, A. M., Zimmers, T. A. & Moraes, C. T., Mar 12 2012, In : PLoS One. 7, 3, e33426.

Research output: Contribution to journalArticle

21 Scopus citations

Long-Term Bezafibrate Treatment Improves Skin and Spleen Phenotypes of the mtDNA Mutator Mouse

Dillon, L. M., Hida, A., Garcia, S., Prolla, T. A. & Moraes, C. T., Sep 4 2012, In : PLoS One. 7, 9, e44335.

Research output: Contribution to journalArticle

22 Scopus citations
35 Scopus citations

Mitochondrial dysfunction induced by heat stress in cultured rat CNS neurons

White, M. G., Saleh, O., Nonner, D., Barrett, E., Moraes, C. T. & Barrett, J., Oct 15 2012, In : Journal of Neurophysiology. 108, 8, p. 2203-2214 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mitochondrial transcription: Lessons from mouse models

Peralta, S., Wang, X. & Moraes, C. T., Sep 1 2012, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1819, 9-10, p. 961-969 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Regional susceptibilities to mitochondrial dysfunctions in the CNS

Pinto, M., Pickrell, A. M. & Moraes, C. T., Mar 1 2012, In : Biological Chemistry. 393, 4, p. 275-281 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

The role of PGC-1 coactivators in aging skeletal muscle and heart

Dillon, L. M., Rebelo, A. P. & Moraes, C. T., Mar 1 2012, In : IUBMB Life. 64, 3, p. 231-241 11 p.

Research output: Contribution to journalArticle

67 Scopus citations
2011

A metabolic shift induced by a PPAR panagonist markedly reduces the effects of pathogenic mitochondrial tRNA mutations

Wenz, T., Wang, X., Marini, M. & Moraes, C. T., Nov 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 11, p. 2317-2325 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels

Wang, X. & Moraes, C. T., Oct 1 2011, In : Molecular Oncology. 5, 5, p. 399-409 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Mitochondrial disorders caused by mutations in respiratory chain assembly factors

Diaz, F., Kotarsky, H., Fellman, V. & Moraes, C. T., Aug 1 2011, In : Seminars in Fetal and Neonatal Medicine. 16, 4, p. 197-204 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Mitochondrial DNA transcription regulation and nucleoid organization

Rebelo, A. P., Dillon, L. M. & Moraes, C. T., Aug 1 2011, In : Journal of Inherited Metabolic Disease. 34, 4, p. 941-951 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease

Pickrell, A. M., Pinto, M., Hida, A. & Moraes, C. T., Nov 30 2011, In : Journal of Neuroscience. 31, 48, p. 17649-17658 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions

Pickrell, A. M., Fukui, H., Wang, X., Pinto, M. & Moraes, C. T., Jul 6 2011, In : Journal of Neuroscience. 31, 27, p. 9895-9904 10 p.

Research output: Contribution to journalArticle

67 Scopus citations