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  • Izidore Lossos
2014

LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma

Lossos, C., Bayraktar, S., Weinzierl, E., Younes, S. F., Hosein, P. J., Tibshirani, R. J., Sutton Posthumus, J., Deangelis, L. M., Raizer, J., Schiff, D., Abrey, L., Natkunam, Y. & Lossos, I. S., Jun 2014, In : British Journal of Haematology. 165, 5, p. 640-648 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Lymphoma associated hemophagocytic syndrome: It's going viral

Hoffman, J. & Lossos, I. S., Sep 2014, In : Leukemia and Lymphoma. 55, 9, p. 1964-1965 2 p.

Research output: Contribution to journalComment/debate

Phase ii study of alisertib, a selective aurora a kinase inhibitor, in relapsed and refractory aggressive B- And T-cell non-Hodgkin lymphomas

Friedberg, J. W., Mahadevan, D., Cebula, E., Persky, D., Lossos, I., Agarwal, A. B., Jung, J. A., Burack, R., Zhou, X., Leonard, E. J., Fingert, H., Danaee, H. & Bernstein, S. H., Jan 1 2014, In : Journal of Clinical Oncology. 32, 1, p. 44-50 7 p.

Research output: Contribution to journalArticle

151 Scopus citations
7 Scopus citations

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

Palomero, T., Couronné, L., Khiabanian, H., Kim, M. Y., Ambesi-Impiombato, A., Perez-Garcia, A., Carpenter, Z., Abate, F., Allegretta, M., Haydu, J. E., Jiang, X., Lossos, I. S., Nicolas, C., Balbin, M., Bastard, C., Bhagat, G., Piris, M. A., Campo, E., Bernard, O. A., Rabadan, R. & 1 others, Ferrando, A. A., Feb 2014, In : Nature genetics. 46, 2, p. 166-170 5 p.

Research output: Contribution to journalArticle

290 Scopus citations

Rosai-dorfman disease of the central nervous system: Report of 6 cases and review of the literature

Sandoval-Sus, J. D., Sandoval-Leon, A. C., Chapman, J. R., Velazquez-Vega, J., Borja, M. J., Rosenberg, S., Lossos, A. & Lossos, I. S., May 2014, In : Medicine (United States). 93, 3, p. 165-175 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

The DNA methylome: A novel biomarker

Lossos, I. S., Mar 13 2014, In : Blood. 123, 11, p. 1627-1628 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma

Green, M. R., Vicente-Dueñas, C., Romero-Camarero, I., Long Liu, C., Dai, B., González-Herrero, I., García-Ramírez, I., Alonso-Escudero, E., Iqbal, J., Chan, W. C., Campos-Sanchez, E., Orfao, A., Pintado, B., Flores, T., Blanco, O., Jiménez, R., Martínez-Climent, J. A., Criado, F. J. G., Cenador, M. B. G., Zhao, S. & 7 others, Natkunam, Y., Lossos, I. S., Majeti, R., Melnick, A., Cobaleda, C., Alizadeh, A. A. & Sánchez-García, I., Jun 2 2014, In : Nature communications. 5, 3904.

Research output: Contribution to journalArticle

50 Scopus citations
2013
6 Scopus citations

CD30 targeting with brentuximab vedotin: A novel therapeutic approach to primary effusion lymphoma

Bhatt, S., Ashlock, B. M., Natkunam, Y., Sujoy, V., Chapman, J. R., Ramos, J. C., Mesri, E. A. & Lossos, I. S., Aug 15 2013, In : Blood. 122, 7, p. 1233-1242 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma

Bhatt, S., Ashlock, B. M., Toomey, N. L., Diaz, L. A., Mesri, E. A., Lossos, I. S. & Ramos, J. C., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2616-2628 13 p.

Research output: Contribution to journalArticle

44 Scopus citations
33 Scopus citations

Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation

Romero-Camarero, I., Jiang, X., Natkunam, Y., Lu, X., Vicente-Dueñas, C., Gonzalez-Herrero, I., Flores, T., Garcia, J. L., McNamara, G., Kunder, C., Zhao, S., Segura, V., Fontan, L., Martínez-Climent, J. A., García-Criado, F. J., Theis, J. D., Dogan, A., Campos-Sánchez, E., Green, M. R., Alizadeh, A. A. & 3 others, Cobaleda, C., Sánchez-García, I. & Lossos, I. S., Oct 28 2013, In : Nature communications. 4, 1338.

Research output: Contribution to journalArticle

32 Scopus citations

LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas

Bertolo, C., Roa, S., Sagardoy, A., Mena-Varas, M., Robles, E. F., Martinez-Ferrandis, J. I., Sagaert, X., Tousseyn, T., Orta, A., Lossos, I. S., Amar, S., Natkunam, Y., Briones, J., Melnick, A., Malumbres, R. & Martinez-Climent, J. A., Sep 1 2013, In : British Journal of Haematology. 162, 5, p. 621-630 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Lymphoma occurring during pregnancy: Antenatal therapy, complications, and maternal survival in a multicenter analysis

Evens, A. M., Advani, R., Press, O. W., Lossos, I. S., Vose, J. M., Hernandez-Ilizaliturri, F. J., Robinson, B. K., Otis, S., Dagan, L. N., Abdallah, R., Kroll-Desrosiers, A., Yarber, J. L., Sandoval, J., Foyil, K., Parker, L. M., Gordon, L. I., Blum, K. A., Flowers, C. R., Leonard, J. P., Habermann, T. M. & 1 others, Bartlett, N. L., Nov 10 2013, In : Journal of Clinical Oncology. 31, 32, p. 4132-4139 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

MicroRNAs in Diffuse Large B-Cell Lymphoma

Lossos, I. & Alencar, A. J., Nov 4 2013, MicroRNAs in Medicine. Wiley Blackwell, p. 419-433 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Ofatumumab in combination with ICE or DHAP chemotherapy in relapsed or refractory intermediate grade B-cell lymphoma

Matasar, M. J., Czuczman, M. S., Rodriguez, M. A., Fennessy, M., Shea, T. C., Spitzer, G., Lossos, I. S., Kharfan-Dabaja, M. A., Joyce, R., Fayad, L., Henkel, K., Liao, Q., Edvardsen, K., Jewell, R. C., Fecteau, D., Singh, R. P., Lisby, S. & Moskowitz, C. H., Jul 25 2013, In : Blood. 122, 4, p. 499-506 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Single-agent lenalidomide is active in patients with relapsed or refractory aggressive non-Hodgkin lymphoma who received prior stem cell transplantation

Vose, J. M., Habermann, T. M., Czuczman, M. S., Zinzani, P. L., Reeder, C. B., Tuscano, J. M., Lossos, I. S., Li, J., Pietronigro, D. & Witzig, T. E., Sep 1 2013, In : British Journal of Haematology. 162, 5, p. 639-647 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
5 Scopus citations
2012

A multicenter phase II study of darinaparsin in relapsed or refractory Hodgkin's and non-Hodgkin's lymphoma

Hosein, P. J., Craig, M. D., Tallman, M. S., Boccia, R. V., Hamilton, B. L., Lewis, J. J. & Lossos, I. S., Jan 1 2012, In : American Journal of Hematology. 87, 1, p. 111-114 4 p.

Research output: Contribution to journalComment/debate

13 Scopus citations

A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors

Vicente-Duenas, C., Romero-Camarero, I., González-Herrero, I., Alonso-Escudero, E., Abollo-Jiménez, F., Jiang, X., Gutierrez, N. C., Orfao, A., Marín, N., Villar, L. M., Criado, M. C. F., Pintado, B., Flores, T., Alonso-López, D., De Las Rivas, J., Jiménez, R., Criado, F. J. G., Cenador, M. B. G., Lossos, I. S., Cobaleda, C. & 1 others, Sánchez-García, I., Sep 12 2012, In : EMBO Journal. 31, 18, p. 3704-3717 14 p.

Research output: Contribution to journalArticle

49 Scopus citations

A retrospective study evaluating the efficacy and safety of bendamustine in the treatment of mantle cell lymphoma

Warsch, S., Hosein, P. J., Maeda, L. S., Alizadeh, A. A. & Lossos, I. S., Jul 1 2012, In : Leukemia and Lymphoma. 53, 7, p. 1299-1305 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice

Vicente-Dueñas, C., Fontán, L., Gonzalez-Herrero, I., Romero-Camarero, I., Segura, V., Aznar, M. A., Alonso-Escudero, E., Campos-Sanchez, E., Ruiz-Roca, L., Barajas-Diego, M., Sagardoy, A., Martinez-Ferrandis, J. I., Abollo-Jimenez, F., Bertolo, C., Peñuelas, I., Garcia-Criado, F. J., García-Cenador, M. B., Tousseyn, T., Agirre, X., Prosper, F. & 15 others, Garcia-Bragado, F., McPhail, E. D., Lossos, I. S., Du, M. Q., Flores, T., Hernandez-Rivas, J. M., Gonzalez, M., Salar, A., Bellosillo, B., Conde, E., Siebert, R., Sagaert, X., Cobaleda, C., Sanchez-Garcia, I. & Martinez-Climent, J. A., Jun 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. 10534-10539 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Genomic analysis of marginal zone and lymphoplasmacytic lymphomas identified common and disease-specific abnormalities

Braggio, E., Dogan, A., Keats, J. J., Chng, W. J., Huang, G., Matthews, J. M., Maurer, M. J., Law, M. E., Bosler, D. S., Barrett, M., Lossos, I. S., Witzig, T. E. & Fonseca, R., May 1 2012, In : Modern Pathology. 25, 5, p. 651-660 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Identification of LMO2 transcriptome and interactome in diffuse large B-cell,lymphoma

Cubedo, E., Gentles, A. J., Huang, C., Natkunam, Y., Bhatt, S., Lu, X., Jiang, X., Romero-Camarero, I., Freud, A., Zhao, S., Bacchi, C. E., Martínez-Climent, J. A., Sanchez-García, I., Melnick, A. & Lossos, I. S., Jun 7 2012, In : Blood. 119, 23, p. 5478-5491 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Immunoglobulin gene repertoire in ocular adnexal lymphomas: Hints on the nature of the antigenic stimulation

Dagklis, A., Ponzoni, M., Govi, S., Cangi, M. G., Pasini, E., Charlotte, F., Vino, A., Doglioni, C., Davì, F., Lossos, I. S., Ntountas, I., Papadaki, T., Dolcetti, R., Ferreri, A. J. M., Stamatopoulos, K. & Ghia, P., Apr 1 2012, In : Leukemia. 26, 4, p. 814-821 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Lack of association of tumor-associated macrophages with clinical outcome in patients with classical hodgkin's lymphoma

Azambuja, D., Natkunam, Y., Biasoli, I., Lossos, I. S., Anderson, M. W., Morais, J. C. & Spector, N., Mar 1 2012, In : Annals of Oncology. 23, 3, p. 736-742 7 p.

Research output: Contribution to journalArticle

63 Scopus citations

LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era

Cerhan, J. R., Natkunam, Y., Morton, L. M., Maurer, M. J., Asmann, Y., Habermann, T. M., Vasef, M. A., Cozen, W., Lynch, C. F., Allmer, C., Slager, S. L., Lossos, I. S., Chanock, S. J., Rothman, N., Hartge, P., Dogan, A. & Wang, S. S., Jun 1 2012, In : Leukemia and Lymphoma. 53, 6, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

miR-155 regulates HGAL expression and increases lymphoma cell motility

Dagan, L. N., Jiang, X., Bhatt, S., Cubedo, E., Rajewsky, K. & Lossos, I. S., Jan 12 2012, In : Blood. 119, 2, p. 513-520 8 p.

Research output: Contribution to journalArticle

51 Scopus citations
7 Scopus citations
2011

A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma

Beltran, E., Fresquet, V., Martinez-Useros, J., Richter-Larrea, J. A., Sagardoy, A., Sesma, I., Almada, L. L., Montes-Moreno, S., Siebert, R., Gesk, S., Calasanz, M. J., Malumbres, R., Rieger, M., Prosper, F., Lossos, I. S., Piris, M. A., Fernandez-Zapico, M. E. & Martinez-Climent, J. A., Jul 26 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 30, p. 12461-12466 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Association between non-Hodgkin lymphoma and renal cell carcinoma

Lossos, C., Ferrell, A., Duncan, R. & Lossos, I. S., Dec 1 2011, In : Leukemia and Lymphoma. 52, 12, p. 2254-2261 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
15 Scopus citations

Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin

Lu, X., Kazmierczak, K., Jiang, X., Jones, M., Watt, J., Helfman, D. M., Moore, J. R., Szczesna-Cordary, D. & Lossos, I. S., Jun 1 2011, In : FEBS Journal. 278, 11, p. 1922-1931 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
3 Scopus citations

Immunostaining to identify molecular subtypes of diffuse large B-cell lymphoma in a population-based epidemiologic study in the pre-rituximab era

Morton, L. M., Cerhan, J. R., Hartge, P., Vasef, M. A., Neppalli, V. T., Natkunam, Y., Dogan, A., Dave, B. J., Jain, S., Levy, R., Lossos, I. S., Cozen, W., Davis, S., Schenk, M. J., Maurer, M. J., Lynch, C. F., Rothman, N., Chatterjee, N., Yu, K., Staudt, L. M. & 2 others, Weisenburger, D. D. & Wang, S. S., Aug 30 2011, In : International Journal of Molecular Epidemiology and Genetics. 2, 3, p. 245-252 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Lack of survival improvement in patients with peripheral T-cell lymphoma: A Surveillance, Epidemiology, and End Results analysis

Morgensztern, D., Walker, G. R., Koniaris, L. G. & Lossos, I. S., Feb 1 2011, In : Leukemia and Lymphoma. 52, 2, p. 194-204 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome

Malumbres, R., Fresquet, V., Roman-Gomez, J., Bobadilla, M., Robles, E. F., Altobelli, G. G., Calasanz, M. J., Smeland, E. B., Aznar, M. A., Agirre, X., Martin-Palanco, V., Prosper, F., Lossos, I. S. & Martinez-Climents, J. A., Jul 1 2011, In : Haematologica. 96, 7, p. 980-986 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

LMO2 protein expression predicts survival in patients with rheumatoid arthritis and diffuse large B-cell lymphoma

Baecklund, E., Backlin, C., Mansouri, M., Klareskog, L., Askling, J., Nyman Iliadou, A., Enblad, G., Lossos, I. S., Natkunam, Y. & Rosenquist, R., Jun 1 2011, In : Leukemia and Lymphoma. 52, 6, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

MicroRNAs are independent predictors of outcome in diffuse large B-cell lymphoma patients treated with R-CHOP

Alencar, A. J., Malumbres, R., Kozloski, G. A., Advani, R., Talreja, N., Chinichian, S., Briones, J., Natkunam, Y., Sehn, L. H., Gascoyne, R. D., Tibshirani, R. & Lossos, I. S., Jun 15 2011, In : Clinical Cancer Research. 17, 12, p. 4125-4135 11 p.

Research output: Contribution to journalArticle

107 Scopus citations

Newly emerging therapies targeting viral-related lymphomas

Ramos, J. C. & Lossos, I. S., Oct 1 2011, In : Current oncology reports. 13, 5, p. 416-426 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL

Cubedo, E., Maurin, M., Jiang, X., Lossos, I. S. & Wright, K. L., Sep 1 2011, In : FEBS Journal. 278, 17, p. 3065-3075 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment

Alizadeh, A. A., Gentles, A. J., Alencar, A. J., Liu, C. L., Kohrt, H. E., Houot, R., Goldstein, M. J., Zhao, S., Natkunam, Y., Advani, R. H., Gascoyne, R. D., Briones, J., Tibshirani, R. J., Myklebust, J. H., Plevritis, S. K., Lossos, I. S. & Levy, R., Aug 4 2011, In : Blood. 118, 5, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

118 Scopus citations

Primary CNS lymphoma in HIV positive and negative patients: Comparison of clinical characteristics, outcome and prognostic factors

Bayraktar, S., Bayraktar, U. D., Ramos, J. C., Stefanovic, A. & Lossos, I. S., Jan 1 2011, In : Journal of neuro-oncology. 101, 2, p. 257-265 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT): Single institution experience in a large cohort of patients

Bayraktar, S., Bayraktar, U. D., Stefanovic, A. & Lossos, I. S., Jan 1 2011, In : British Journal of Haematology. 152, 1, p. 72-80 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

The authors' reply

Montague, N. & Lossos, I. S., Jun 1 2011, In : American journal of clinical pathology. 135, 6, p. 978-979 2 p.

Research output: Contribution to journalLetter

The efficacy of HGAL and LMO2 in the separation of lymphomas derived from small B cells in nodal and extranodal sites, including the bone marrow

Younes, S. F., Beck, A. H., Ohgami, R. S., Lossos, I. S., Levy, R., Warnke, R. A. & Natkunam, Y., May 1 2011, In : American journal of clinical pathology. 135, 5, p. 697-708 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Transformation of follicular lymphoma

Lossos, I. S. & Gascoyne, R. D., Jun 2011, In : Best Practice and Research: Clinical Haematology. 24, 2, p. 147-163 17 p.

Research output: Contribution to journalReview article

83 Scopus citations

Utility of positron emission tomography scans in mantle cell lymphoma

Hosein, P. J., Pastorini, V. H., Paes, F. M., Eber, D., Chapman, J. R., Serafini, A. N., Alizadeh, A. A. & Lossos, I. S., Oct 1 2011, In : American Journal of Hematology. 86, 10, p. 841-845 5 p.

Research output: Contribution to journalArticle

39 Scopus citations