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  • Ronald Charles Desrosiers
Article

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

Fuchs, S. P., Martinez-Navio, J. M., Piatak, M., Lifson, J. D., Gao, G. & Desrosiers, R. C., Aug 1 2015, In : PLoS pathogens. 11, 8, e1005090.

Research output: Contribution to journalArticle

49 Scopus citations

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Gardner, M. R., Kattenhorn, L. M., Kondur, H. R., Von Schaewen, M., Dorfman, T., Chiang, J. J., Haworth, K. G., Decker, J. M., Alpert, M. D., Bailey, C. C., Neale, E. S., Fellinger, C. H., Joshi, V. R., Fuchs, S. P., Martinez-Navio, J. M., Quinlan, B. D., Yao, A. Y., Mouquet, H., Gorman, J., Zhang, B. & 14 others, Poignard, P., Nussenzweig, M. C., Burton, D. R., Kwong, P. D., Piatak, M., Lifson, J. D., Gao, G., Desrosiers, R. C., Evans, D. T., Hahn, B. H., Ploss, A., Cannon, P. M., Seaman, M. S. & Farzan, M., Mar 5 2015, In : Nature. 519, 7541, p. 87-91 5 p.

Research output: Contribution to journalArticle

173 Scopus citations

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi’s sarcoma-associated herpesvirus and rhesus monkey rhadinovirus

Großkopf, A. K., Ensser, A., Neipel, F., Jungnickl, D., Schlagowski, S., Desrosiers, R. C. & Hahn, A. S., Feb 2018, In : PLoS pathogens. 14, 2, e1006912.

Research output: Contribution to journalArticle

8 Scopus citations

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

Alpert, M. D., Harvey, J. D., Lauer, W. A., Reeves, R. K., Piatak, M., Carville, A., Mansfield, K. G., Lifson, J. D., Li, W., Desrosiers, R. C., Johnson, R. P. & Evans, D. T., Aug 2012, In : PLoS pathogens. 8, 8, e1002890.

Research output: Contribution to journalArticle

113 Scopus citations

A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus

Magnani, D. M., Silveira, C. G. T., Rosen, B. C., Ricciardi, M. J., Pedreño-Lopez, N., Gutman, M. J., Bailey, V. K., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Avelino-Silva, V. I., Trindade, M., Nogueira, J., Oliveira, C. S., Maestri, A., Felix, A. C., Levi, J. E., Nogueira, M. L., Martins, M. A., Martinez-Navio, J. M. & 6 others, Fuchs, S. P., Whitehead, S. S., Burton, D. R., Desrosiers, R. C., Kallas, E. G. & Watkins, D. I., Jun 12 2017, In : PLoS neglected tropical diseases. 11, 6, e0005655.

Research output: Contribution to journalArticle

12 Scopus citations

A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products

Shin, Y. C., Bischof, G. F., Lauer, W. A., Gonzalez-Nieto, L., Rakasz, E. G., Hendricks, G. M., Watkins, D. I., Martins, M. A. & Desrosiers, R. C., Jun 2018, In : PLoS pathogens. 14, 6, e1007143.

Research output: Contribution to journalArticle

6 Scopus citations

A recombinant rhesus monkey rhadinovirus deleted of glycoprotein L establishes persistent infection of rhesus macaques and elicits conventional T cell responses

Hahn, A. S., Bischof, G. F., Großkopf, A. K., Shin, Y. C., Domingues, A., Gonzalez-Nieto, L., Rakasz, E. G., Watkins, D. I., Ensser, A., Martins, M. A. & Desrosiers, R. C., Jan 1 2020, In : Journal of virology. 94, 2, e01093-19.

Research output: Contribution to journalArticle

Cellular immune responses against simian T-lymphotropic virus type 1 target Tax in infected baboons

Castro, I., Giret, T. M., Magnani, D. M., Maxwell, H. S., Umland, O., Perry, J. K., Pecotte, J. K., Brasky, K. M., Barber, G. N., Desrosiers, R. C. & Watkins, D. I., Jun 1 2016, In : Journal of virology. 90, 11, p. 5280-5291 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Comparative characterization of transfection-and infection-derived simian immunodeficiency virus challenge stocks for In Vivo nonhuman primate studies

Del Prete, G. Q., Scarlotta, M., Newman, L., Reid, C., Parodi, L. M., Roser, J. D., Oswald, K., Marx, P. A., Miller, C. J., Desrosiers, R. C., Barouch, D. H., Pal, R., Piatak, M., Chertova, E., Giavedoni, L. D., O'Connor, D. H., Lifson, J. D. & Keele, B. F., Apr 2013, In : Journal of virology. 87, 8, p. 4584-4595 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys

Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Pedreño-Lopez, N., Silveira, C. G. T., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Su, Q., Newman, R. M., Pack, M., Martins, M. A., Martinez-Navio, J. M., Fuchs, S. P., Rakasz, E. G., Allen, T. M., Whitehead, S. S., Burton, D. R., Gao, G. & 3 others, Desrosiers, R. C., Kallas, E. G. & Watkins, D. I., Oct 4 2017, In : Molecular Therapy. 25, 10, p. 2323-2331 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies

Silver, Z. A., Antonopoulos, A., Haslam, S. M., Dell, A., Dickinson, G. M., Seaman, M. S. & Desrosiers, R. C., Feb 11 2020, In : Cell Reports. 30, 6, p. 1862-1869.e4

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Evidence against extracellular exposure of a highly immunogenic region in the C-terminal domain of the simian immunodeficiency virus gp41 transmembrane protein

Postler, T. S., Martinez-Navio, J. M., Yuste, E. & Desrosiers, R. C., Jan 2012, In : Journal of virology. 86, 2, p. 1145-1157 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques

Magnani, D. M., Rogers, T. F., Maness, N. J., Grubaugh, N. D., Beutler, N., Bailey, V. K., Gonzalez-Nieto, L., Gutman, M. J., Pedreño-Lopez, N., Kwal, J. M., Ricciardi, M. J., Myers, T. A., Julander, J. G., Bohm, R. P., Gilbert, M. H., Schiro, F., Aye, P. P., Blair, R. V., Martins, M. A., Falkenstein, K. P. & 12 others, Kaur, A., Curry, C. L., Kallas, E. G., Desrosiers, R. C., Goldschmidt-Clermont, P. J., Whitehead, S. S., Andersen, K. G., Bonaldo, M. C., Lackner, A. A., Panganiban, A. T., Burton, D. R. & Watkins, D. I., Dec 1 2018, In : Nature communications. 9, 1, 1624.

Research output: Contribution to journalArticle

26 Scopus citations

Gp120 on HIV-1 virions lacks O-linked carbohydrate

Stansell, E., Panico, M., Canis, K., Pang, P. C., Bouché, L., Binet, D., O'Connor, M. J., Chertova, E., Bess, J., Lifson, J. D., Haslam, S. M., Morris, H. R., Desrosiers, R. C. & Dell, A., Apr 27 2015, In : PloS one. 10, 4, e0124784.

Research output: Contribution to journalArticle

18 Scopus citations

HEK293T cell lines defective for O-linked glycosylation

Termini, J. M., Silver, Z. A., Connor, B., Antonopoulos, A., Haslam, S. M., Dell, A. & Desrosiers, R. C., Jun 2017, In : PloS one. 12, 6, e0179949.

Research output: Contribution to journalArticle

6 Scopus citations

Host Anti-antibody Responses Following Adeno-associated Virus–mediated Delivery of Antibodies Against HIV and SIV in Rhesus Monkeys

Martinez-Navio, J. M., Fuchs, S. P., Pedreño-López, S., Rakasz, E. G., Gao, G. & Desrosiers, R. C., Oct 7 2015, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

36 Scopus citations

Human immunodeficiency virus and simian immunodeficiency virus maintain high levels of infectivity in the complete absence of mucin-type O-glycosylation

Termini, J. M., Church, E. S., Silver, Z. A., Haslam, S. M., Dell, A. & Desrosiers, R. C., Oct 1 2017, In : Journal of virology. 91, 19, e01228-17.

Research output: Contribution to journalArticle

3 Scopus citations

Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection

Postler, T. S., Pantry, S. N., Desrosiers, R. C. & Ghosh, S., Nov 2017, In : Virology. 511, p. 30-39 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Importance of codon usage for the temporal regulation of viral gene expression

Shin, Y. C., Bischof, G. F., Lauer, W. A. & Desrosiers, R. C., Nov 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 14030-14035 6 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Influence of mismatch of env sequences on vaccine protection by live attenuated simian immunodeficiency virus

Manrique, J., Piatak, M., Lauer, W., Johnson, W., Mansfield, K., Lifson, J. & Desrosiers, R., Jul 1 2013, In : Journal of virology. 87, 13, p. 7246-7254 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys

Fuchs, S. P., Martinez-Navio, J. M., Rakasz, E. G., Gao, G. & Desrosiers, R. C., Mar 13 2020, In : Molecular Therapy - Methods and Clinical Development. 16, p. 94-102 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV

Martinez-Navio, J. M., Fuchs, S. P., Mendes, D. E., Rakasz, E. G., Gao, G., Lifson, J. D. & Desrosiers, R. C., Mar 17 2020, In : Frontiers in immunology. 11, 449.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Magnitude and quality of cytokine and chemokine storm during acute infection distinguish nonprogressive and progressive simian immunodeficiency virus infections of nonhuman primates

Keating, S. M., Heitman, J. W., Wu, S., Deng, X., Stacey, A. R., Zahn, R. C., de la Rosa, M., Finstad, S. L., Lifson, J. D., Piatak, M., Gauduin, M. C., Kessler, B. M., Ternette, N., Carville, A., Johnson, R. P., Desrosiers, R. C., Letvin, N. L., Borrow, P., Norris, P. J. & Schmitz, J. E., 2016, In : Journal of virology. 90, 22, p. 10339-10350 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mamu-B*17+ rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication

Martins, M. A., Tully, D. C., Pedreño-Lopez, N., Bredow, B. V., Pauthner, M. G., Shin, Y. C., Yuan, M., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Altman, J. D., Burton, D. R., Ejima, K., Allison, D. B. & 9 others, Evans, D. T., Rakasz, E. G., Parks, C. L., Bonaldo, M. C., Capuano, S., Lifson, J. D., Desrosiers, R. C., Allen, T. M. & Watkins, D. I., Aug 1 2018, In : Journal of virology. 92, 16, e00690-18.

Research output: Contribution to journalArticle

3 Scopus citations

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

Panico, M., Bouché, L., Binet, D., O'Connor, M. J., Rahman, D., Pang, P. C., Canis, K., North, S. J., Desrosiers, R. C., Chertova, E., Keele, B. F., Bess, J. W., Lifson, J. D., Haslam, S. M., Dell, A. & Morris, H. R., Sep 8 2016, In : Scientific reports. 6, 32956.

Research output: Contribution to journalArticle

40 Scopus citations
5 Scopus citations

Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strube, A., Gutman, M. J., Pedreno-Lopez, N., Grubaugh, N. D., Silveira, C. G. T., Maxwell, H. S., Domingues, A., Martins, M. A., Lee, D. E., Okwuazi, E. E., Jean, S. & 10 others, Strobert, E. A., Chahroudi, A., Silvestri, G., Vanderford, T. H., Kallas, E. G., Desrosiers, R. C., Bonaldo, M. C., Whitehead, S. S., Burton, D. R. & Watkins, D. I., Oct 4 2017, In : Science Translational Medicine. 9, 410, aan8184.

Research output: Contribution to journalArticle

46 Scopus citations

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

Adnan, S., Reeves, R. K., Gillis, J., Wong, F. E., Yu, Y., Camp, J. V., Li, Q., Connole, M., Li, Y., Piatak, M., Lifson, J. D., Li, W., Keele, B. F., Kozlowski, P. A., Desrosiers, R. C., Haase, A. T. & Johnson, R. P., Dec 13 2016, In : PLoS pathogens. 12, 12, e1006104.

Research output: Contribution to journalArticle

16 Scopus citations

Potent plasmablast-derived antibodies elicited by the National Institutes of Health dengue vaccine

Magnani, D. M., Silveira, C. G. T., Ricciardi, M. J., Gonzalez-Nieto, L., Pedreño-Lopez, N., Bailey, V. K., Gutman, M. J., Maxwell, H. S., Domingues, A., Costa, P. R., Ferrari, L., Goulart, R., Martins, M. A., Martinez-Navio, J. M., Fuchs, S. P., Kalil, J., Timenetsky, M. D. C., Wrammert, J., Whitehead, S. S., Burton, D. R. & 3 others, Desrosiers, R. C., Kallas, E. G. & Watkins, D. I., Nov 1 2017, In : Journal of virology. 91, 22, e00867-17.

Research output: Contribution to journalArticle

10 Scopus citations

Protection against HIV acquisition in the RV144 trial

Desrosiers, R. C., Sep 1 2017, In : Journal of virology. 91, 18, e00905-17.

Research output: Contribution to journalArticle

11 Scopus citations

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque

Martins, M. A., Tully, D. C., Shin, Y. C., Gonzalez-Nieto, L., Weisgrau, K. L., Bean, D. J., Gadgil, R., Gutman, M. J., Domingues, A., Maxwell, H. S., Magnani, D. M., Ricciardi, M., Pedreño-Lopez, N., Bailey, V., Cruz, M. A., Lima, N. S., Bonaldo, M. C., Altman, J. D., Rakasz, E., Capuano, S. & 6 others, Reimann, K. A., Piatak, M., Lifson, J. D., Desrosiers, R. C., Allen, T. M. & Watkins, D. I., Aug 2017, In : AIDS research and human retroviruses. 33, 8, p. 843-858 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Recombinant AAV vectors for enhanced expression of authentic IgG

Fuchs, S. P., Martinez-Navio, J. M., Gao, G. & Desrosiers, R. C., Jun 2016, In : PloS one. 11, 6, e0158009.

Research output: Contribution to journalArticle

11 Scopus citations

Rhesus monkey rhadinovirus isolated from hemangioma tissue

Ensser, A., Yasuda, K., Lauer, W., Desrosiers, R. C. & Hahn, A. S., Mar 19 2020, In : Microbiology Resource Announcements. 9, 12, e01347-19.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Simian T lymphotropic virus 1 Infection of Papio anubis: Tax sequence heterogeneity and T cell recognition

Termini, J. M., Magnani, D. M., Maxwell, H. S., Lauer, W., Castro, I., Pecotte, J., Barber, G. N., Watkins, D. I. & Desrosiers, R. C., Oct 1 2017, In : Journal of virology. 91, 20, e00950-17.

Research output: Contribution to journalArticle

2 Scopus citations

The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1

Postler, T. S. & Desrosiers, R. C., Feb 16 2012, In : Cell Host and Microbe. 11, 2, p. 181-193 13 p.

Research output: Contribution to journalArticle

49 Scopus citations

Use of a gamma-2 herpesvirus as a vector to deliver antibodies to rhesus monkeys

Bischof, G. F., Shin, Y. C., Fuchs, S. P., Martinez-Navio, J. M., Lauer, W. A., Rakasz, E. G. & Desrosiers, R. C., Aug 1 2017, In : Gene Therapy. 24, 8, p. 487-492 6 p.

Research output: Contribution to journalArticle

Use of a recombinant gamma-2 herpesvirus vaccine vector against dengue virus in rhesus monkeys

Bischof, G. F., Magnani, D. M., Ricciardi, M., Shin, Y. C., Domingues, A., Bailey, V. K., Gonzalez-Nieto, L., Rakasz, E. G., Watkins, D. I. & Desrosiers, R. C., Aug 1 2017, In : Journal of virology. 91, 16, e00525-17.

Research output: Contribution to journalArticle

2 Scopus citations

Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques

Martins, M. A., Shin, Y. C., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Castro, I., Magnani, D. M., Ricciardi, M., Pedreño-Lopez, N., Bailey, V., Betancourt, D., Altman, J. D., Pauthner, M., Burton, D. R., von Bredow, B., Evans, D. T., Yuan, M., Parks, C. L., Ejima, K. & 7 others, Allison, D. B., Rakasz, E., Barber, G. N., Capuano, S., Lifson, J. D., Desrosiers, R. C. & Watkins, D. I., Jul 2017, In : PLoS pathogens. 13, 7, e1006529.

Research output: Contribution to journalArticle

11 Scopus citations

With differences in acute viremia in simian immunodeficiency virus δnef-infected animals

Janaka, S. K., Tavakoli-Tameh, A., Neidermyer, W. J., Serra-Moreno, R., Hoxie, J. A., Desrosiers, R. C., Paul Johnson, R., Lifson, J. D., Wolinsky, S. M. & Evans, D. T., Nov 1 2018, In : Journal of virology. 92, 22, e00542.

Research output: Contribution to journalArticle

3 Scopus citations
Chapter

Nonhuman lentiviruses

Evans, D. T., Elder, J. H. & Desrosiers, R. C., May 21 2013, Fields Virology: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations
Review article
32 Scopus citations
Short survey

The tale of the long tail: The cytoplasmic domain of HIV-1 gp41

Postler, T. S. & Desrosiers, R. C., Jan 2013, In : Journal of virology. 87, 1, p. 2-15 14 p.

Research output: Contribution to journalShort survey

65 Scopus citations