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Author

  • Ronald Charles Desrosiers
Article

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

Fuchs, S. P., Martinez-Navio, J. M., Piatak, M., Lifson, J. D., Gao, G. & Desrosiers, R. C., Aug 1 2015, In : PLoS pathogens. 11, 8, e1005090.

Research output: Contribution to journalArticle

48 Scopus citations

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Gardner, M. R., Kattenhorn, L. M., Kondur, H. R., Von Schaewen, M., Dorfman, T., Chiang, J. J., Haworth, K. G., Decker, J. M., Alpert, M. D., Bailey, C. C., Neale, E. S., Fellinger, C. H., Joshi, V. R., Fuchs, S. P., Martinez-Navio, J. M., Quinlan, B. D., Yao, A. Y., Mouquet, H., Gorman, J., Zhang, B. & 14 others, Poignard, P., Nussenzweig, M. C., Burton, D. R., Kwong, P. D., Piatak, M., Lifson, J. D., Gao, G., Desrosiers, R. C., Evans, D. T., Hahn, B. H., Ploss, A., Cannon, P. M., Seaman, M. S. & Farzan, M., Mar 5 2015, In : Nature. 519, 7541, p. 87-91 5 p.

Research output: Contribution to journalArticle

172 Scopus citations

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi’s sarcoma-associated herpesvirus and rhesus monkey rhadinovirus

Großkopf, A. K., Ensser, A., Neipel, F., Jungnickl, D., Schlagowski, S., Desrosiers, R. C. & Hahn, A. S., Feb 2018, In : PLoS pathogens. 14, 2, e1006912.

Research output: Contribution to journalArticle

8 Scopus citations

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

Alpert, M. D., Harvey, J. D., Lauer, W. A., Reeves, R. K., Piatak, M., Carville, A., Mansfield, K. G., Lifson, J. D., Li, W., Desrosiers, R. C., Johnson, R. P. & Evans, D. T., Aug 2012, In : PLoS pathogens. 8, 8, e1002890.

Research output: Contribution to journalArticle

112 Scopus citations

Adeno-Associated Virus Delivery of Anti-HIV Monoclonal Antibodies Can Drive Long-Term Virologic Suppression

Martinez-Navio, J. M., Fuchs, S. P., Pantry, S. N., Lauer, W. A., Duggan, N. N., Keele, B. F., Rakasz, E. G., Gao, G., Lifson, J. D. & Desrosiers, R. C., Mar 19 2019, In : Immunity. 50, 3, p. 567-575.e5

Research output: Contribution to journalArticle

16 Scopus citations

A highly unusual v1 region of env in an elite controller of HIV infection

Silver, Z. A., Dickinson, G. M., Seaman, M. S. & Desrosiers, R. C., May 1 2019, In : Journal of virology. 93, 10, e00094-19.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies

Gardner, M. R., Fetzer, I., Kattenhorn, L. M., Davis-Gardner, M. E., Zhou, A. S., Alfant, B., Weber, J. A., Kondur, H. R., Martinez-Navio, J. M., Fuchs, S. P., Desrosiers, R. C., Gao, G., Lifson, J. D. & Farzan, M., Mar 6 2019, In : Molecular Therapy. 27, 3, p. 650-660 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products

Shin, Y. C., Bischof, G. F., Lauer, W. A., Gonzalez-Nieto, L., Rakasz, E. G., Hendricks, G. M., Watkins, D. I., Martins, M. A. & Desrosiers, R. C., Jun 2018, In : PLoS pathogens. 14, 6, e1007143.

Research output: Contribution to journalArticle

5 Scopus citations

A recombinant rhesus monkey rhadinovirus deleted of glycoprotein L establishes persistent infection of rhesus macaques and elicits conventional T cell responses

Hahn, A. S., Bischof, G. F., Großkopf, A. K., Shin, Y. C., Domingues, A., Gonzalez-Nieto, L., Rakasz, E. G., Watkins, D. I., Ensser, A., Martins, M. A. & Desrosiers, R. C., Jan 1 2020, In : Journal of virology. 94, 2, e01093-19.

Research output: Contribution to journalArticle

17 Scopus citations

Cellular immune responses against simian T-lymphotropic virus type 1 target Tax in infected baboons

Castro, I., Giret, T. M., Magnani, D. M., Maxwell, H. S., Umland, O., Perry, J. K., Pecotte, J. K., Brasky, K. M., Barber, G. N., Desrosiers, R. C. & Watkins, D., Jun 1 2016, In : Journal of Virology. 90, 11, p. 5280-5291 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity

Xiao, Y., Muhuri, M., Li, S., Qin, W., Xu, G., Luo, L., Li, J., Letizia, A. J., Wang, S. K., Chan, Y. K., Wang, C., Fuchs, S. P., Wang, D., Su, Q., Abu Nahid, M., Church, G. M., Farzan, M., Yang, L., Wei, Y., Desrosiers, R. C. & 3 others, Mueller, C., Tai, P. W. L. & Gao, G., Jul 11 2019, In : JCI Insight. 4, 13, e99052.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Comparative characterization of transfection-and infection-derived simian immunodeficiency virus challenge stocks for In Vivo nonhuman primate studies

Del Prete, G. Q., Scarlotta, M., Newman, L., Reid, C., Parodi, L. M., Roser, J. D., Oswald, K., Marx, P. A., Miller, C. J., Desrosiers, R. C., Barouch, D. H., Pal, R., Piatak, M., Chertova, E., Giavedoni, L. D., O'Connor, D. H., Lifson, J. D. & Keele, B. F., Apr 1 2013, In : Journal of virology. 87, 8, p. 4584-4595 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies

Silver, Z. A., Antonopoulos, A., Haslam, S. M., Dell, A., Dickinson, G. M., Seaman, M. S. & Desrosiers, R. C., Feb 11 2020, In : Cell Reports. 30, 6, p. 1862-1869.e4

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

EphA7 functions as receptor on BJAB cells for cell-to-cell transmission of the Kaposi’s sarcoma-associated herpesvirus and for cell-free infection by the related rhesus monkey Rhadinovirus

Großkopf, A. K., Schlagowski, S., Hörnich, B. F., Fricke, T., Desrosiers, R. C. & Hahn, A. S., Jan 1 2019, In : Journal of virology. 93, 15, e00064-19.

Research output: Contribution to journalArticle

5 Scopus citations

Evidence against extracellular exposure of a highly immunogenic region in the C-terminal domain of the simian immunodeficiency virus gp41 transmembrane protein

Postler, T. S., Martinez-Navio, J. M., Yuste, E. & Desrosiers, R. C., Jan 1 2012, In : Journal of virology. 86, 2, p. 1145-1157 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques

Magnani, D. M., Rogers, T. F., Maness, N. J., Grubaugh, N. D., Beutler, N., Bailey, V. K., Gonzalez-Nieto, L., Gutman, M. J., Pedreño-Lopez, N., Kwal, J. M., Ricciardi, M. J., Myers, T. A., Julander, J. G., Bohm, R. P., Gilbert, M. H., Schiro, F., Aye, P. P., Blair, R. V., Martins, M. A., Falkenstein, K. P. & 12 others, Kaur, A., Curry, C. L., Kallas, E. G., Desrosiers, R. C., Goldschmidt-Clermont, P. J., Whitehead, S. S., Andersen, K. G., Bonaldo, M. C., Lackner, A. A., Panganiban, A. T., Burton, D. R. & Watkins, D. I., Dec 1 2018, In : Nature communications. 9, 1, 1624.

Research output: Contribution to journalArticle

23 Scopus citations

Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10

Yang, B., Li, S., Wang, H., Guo, Y., Gessler, D. J., Cao, C., Su, Q., Kramer, J., Zhong, L., Ahmed, S. S., Zhang, H., He, R., Desrosiers, R. C., Brown, R., Xu, Z. & Gao, G., Jul 2014, In : Molecular Therapy. 22, 7, p. 1299-1309 11 p.

Research output: Contribution to journalArticle

102 Scopus citations

Gp120 on HIV-1 virions lacks O-linked carbohydrate

Stansell, E., Panico, M., Canis, K., Pang, P. C., Bouché, L., Binet, D., O'Connor, M. J., Chertova, E., Bess, J., Lifson, J. D., Haslam, S. M., Morris, H. R., Desrosiers, R. C. & Dell, A., Apr 27 2015, In : PloS one. 10, 4, e0124784.

Research output: Contribution to journalArticle

18 Scopus citations

Host Anti-antibody Responses Following Adeno-associated Virus–mediated Delivery of Antibodies Against HIV and SIV in Rhesus Monkeys

Martinez-Navio, J. M., Fuchs, S. P., Pedreño-López, S., Rakasz, E. G., Gao, G. & Desrosiers, R. C., Oct 7 2015, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

36 Scopus citations

Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques

Yen, P. J., Mefford, M. E., Hoxie, J. A., Williams, K. C., Desrosiers, R. C. & Gabuzda, D., Jun 2014, In : Virology. 458-459, 1, p. 53-68 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Importance of codon usage for the temporal regulation of viral gene expression

Shin, Y. C., Bischof, G. F., Lauer, W. A. & Desrosiers, R. C., Nov 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 14030-14035 6 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Influence of mismatch of env sequences on vaccine protection by live attenuated simian immunodeficiency virus

Manrique, J., Piatak, M., Lauer, W., Johnson, W., Mansfield, K., Lifson, J. & Desrosiers, R., Jul 1 2013, In : Journal of virology. 87, 13, p. 7246-7254 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys

Fuchs, S. P., Martinez-Navio, J. M., Rakasz, E. G., Gao, G. & Desrosiers, R. C., Mar 13 2020, In : Molecular Therapy - Methods and Clinical Development. 16, p. 94-102 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV

Martinez-Navio, J. M., Fuchs, S. P., Mendes, D. E., Rakasz, E. G., Gao, G., Lifson, J. D. & Desrosiers, R. C., Mar 17 2020, In : Frontiers in immunology. 11, 449.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Magnitude and quality of cytokine and chemokine storm during acute infection distinguish nonprogressive and progressive simian immunodeficiency virus infections of nonhuman primates

Keating, S. M., Heitman, J. W., Wu, S., Deng, X., Stacey, A. R., Zahn, R. C., de la Rosa, M., Finstad, S. L., Lifson, J. D., Piatak, M., Gauduin, M. C., Kessler, B. M., Ternette, N., Carville, A., Johnson, R. P., Desrosiers, R. C., Letvin, N. L., Borrow, P., Norris, P. J. & Schmitz, J. E., 2016, In : Journal of virology. 90, 22, p. 10339-10350 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mamu-B*17+ rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication

Martins, M. A., Tully, D. C., Pedreño-Lopez, N., Bredow, B. V., Pauthner, M. G., Shin, Y. C., Yuan, M., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Altman, J. D., Burton, D. R., Ejima, K., Allison, D. B. & 9 others, Evans, D. T., Rakasz, E. G., Parks, C. L., Bonaldo, M. C., Capuano, S., Lifson, J. D., Desrosiers, R. C., Allen, T. M. & Watkins, D. I., Aug 1 2018, In : Journal of virology. 92, 16, e00690-18.

Research output: Contribution to journalArticle

2 Scopus citations

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

Panico, M., Bouché, L., Binet, D., O'Connor, M. J., Rahman, D., Pang, P. C., Canis, K., North, S. J., Desrosiers, R. C., Chertova, E., Keele, B. F., Bess, J. W., Lifson, J. D., Haslam, S. M., Dell, A. & Morris, H. R., Sep 8 2016, In : Scientific reports. 6, 32956.

Research output: Contribution to journalArticle

39 Scopus citations

Neutralizing capacity of monoclonal antibodies that recognize peptide sequences underlying the carbohydrates on gp41 of simian immunodeficiency virus

Martinez-Navio, J. M. & Desrosiers, R. C., Dec 1 2012, In : Journal of virology. 86, 23, p. 12484-12493 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

Adnan, S., Reeves, R. K., Gillis, J., Wong, F. E., Yu, Y., Camp, J. V., Li, Q., Connole, M., Li, Y., Piatak, M., Lifson, J. D., Li, W., Keele, B. F., Kozlowski, P. A., Desrosiers, R. C., Haase, A. T. & Johnson, R. P., Dec 13 2016, In : PLoS pathogens. 12, 12, e1006104.

Research output: Contribution to journalArticle

16 Scopus citations

Recombinant AAV vectors for enhanced expression of authentic IgG

Fuchs, S. P., Martinez-Navio, J. M., Gao, G. & Desrosiers, R. C., Jun 2016, In : PloS one. 11, 6, e0158009.

Research output: Contribution to journalArticle

11 Scopus citations

Rhesus monkey rhadinovirus isolated from hemangioma tissue

Ensser, A., Yasuda, K., Lauer, W., Desrosiers, R. C. & Hahn, A. S., Mar 19 2020, In : Microbiology Resource Announcements. 9, 12, e01347-19.

Research output: Contribution to journalArticle

Open Access

Rhesus Monkey Rhadinovirus Uses Eph Family Receptors for Entry into B Cells and Endothelial Cells but Not Fibroblasts

Hahn, A. S. & Desrosiers, R. C., May 1 2013, In : PLoS pathogens. 9, 5, e1003360.

Research output: Contribution to journalArticle

21 Scopus citations

SIV Vpx is essential for macrophage infection but not for development of AIDS

Westmoreland, S. V., Converse, A. P., Hrecka, K., Hurley, M., Knight, H., Piatak, M., Lifson, J., Mansfield, K. G., Skowronski, J. & Desrosiers, R. C., Jan 21 2014, In : PloS one. 9, 1, e84463.

Research output: Contribution to journalArticle

19 Scopus citations

Systematic analysis of intracellular trafficking motifs located within the cytoplasmic domain of simian immunodeficiency virus glycoprotein gp41

Postler, T. S., Bixby, J. G., Desrosiers, R. C., Yuste, E. & Ambrose, Z., Dec 5 2014, In : PloS one. 9, 12, e114753.

Research output: Contribution to journalArticle

4 Scopus citations

The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1

Postler, T. S. & Desrosiers, R. C., Feb 16 2012, In : Cell Host and Microbe. 11, 2, p. 181-193 13 p.

Research output: Contribution to journalArticle

49 Scopus citations

The frequency of vaccine-induced T-cell responses does not predict the rate of acquisition after repeated intrarectal SIVmac239 challenges in MAMU-B*08 rhesus macaques

Martins, M., Gonzalez-Nieto, L., Shin, Y. C., Domingues, A., Gutman, M. J., Maxwell, H. S., Magnani, D. M., Ricciardi, M. J., Pedreño-Lopez, N., Bailey, V. K., Altman, J. D., Parks, C. L., Allison, D. B., Ejima, K., Rakasz, E. G., Capuano, S., Desrosiers, R. C., Lifson, J. D. & Watkins, D., Mar 1 2019, In : Journal of Virology. 93, 5, e01626-18.

Research output: Contribution to journalArticle

1 Scopus citations

Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques

Gonzalez-Nieto, L., Castro, I. M., Bischof, G. F., Shin, Y. C., Ricciardi, M. J., Bailey, V. K., Dang, C. M., Pedreño-Lopez, N., Magnani, D. M., Ejima, K., Allison, D. B., Gil, H. M., Evans, D. T., Rakasz, E. G., Lifson, J. D., Desrosiers, R. C. & Martins, M. A., Jan 1 2019, In : PLoS pathogens. 15, 9, e1008015.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Vaccine protection against SIVmac239 acquisition

Martins, M. A., Bischof, G. F., Shin, Y. C., Lauer, W. A., Gonzalez-Nieto, L., Watkins, D. I., Rakasz, E. G., Lifson, J. D. & Desrosiers, R. C., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1739-1744 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

With differences in acute viremia in simian immunodeficiency virus δnef-infected animals

Janaka, S. K., Tavakoli-Tameh, A., Neidermyer, W. J., Serra-Moreno, R., Hoxie, J. A., Desrosiers, R. C., Paul Johnson, R., Lifson, J. D., Wolinsky, S. M. & Evans, D. T., Nov 1 2018, In : Journal of Virology. 92, 22, e00542.

Research output: Contribution to journalArticle

3 Scopus citations
Chapter

Nonhuman lentiviruses

Evans, D. T., Elder, J. H. & Desrosiers, R. C., May 21 2013, Fields Virology: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations
Comment/debate

Localization of productively infected cells in the Spleen and Peyer's patches of rhesus macaques during acute infection with SIVmac239Δnef- enhanced green fluorescent protein

Yang, G. B., Alexander, L., Aye, P., Alvarez, X., Desrosiers, R. C. & Lackner, A. A., Jan 1 2014, In : AIDS research and human retroviruses. 30, 8, p. 738-739 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
Letter

Reply to “on the use of 2,5-dimethyl-pyrrol-1-yl-benzoic acid derivatives as EPH-ephrin antagonists“

Desrosiers, R. C. & Hahn, A. S., Jan 1 2014, In : Journal of virology. 88, 20, 1 p.

Research output: Contribution to journalLetter

Review article
31 Scopus citations
Short survey

The tale of the long tail: The cytoplasmic domain of HIV-1 gp41

Postler, T. S. & Desrosiers, R. C., Jan 1 2013, In : Journal of virology. 87, 1, p. 2-15 14 p.

Research output: Contribution to journalShort survey

64 Scopus citations