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  • Ralf Paus
Article

2,4,6-Octatrienoic acid is a novel promoter of melanogenesis and antioxidant defence in normal human melanocytes via PPAR-γ activation

Flori, E., Mastrofrancesco, A., Kovacs, D., Ramot, Y., Briganti, S., Bellei, B., Paus, R. & Picardo, M., Aug 1 2011, In : Pigment Cell and Melanoma Research. 24, 4, p. 618-630 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata

Bertolini, M., Zilio, F., Rossi, A., Kleditzsch, P., Emelianov, V. E., Gilhar, A., Keren, A., Meyer, K. C., Wang, E., Funk, W., McElwee, K. & Paus, R., May 15 2014, In : PloS one. 9, 5, e94260.

Research output: Contribution to journalArticle

61 Scopus citations

Abstracts

Gkogkolou, P., Sarna, M., Sarna, T., Paus, R., Luger, T. A. & Böhm, M., Apr 1 2019, In : The British journal of dermatology. 180, 4, p. e108-e139

Research output: Contribution to journalArticle

Open Access

Activation of transient receptor potential vanilloid-3 inhibits human hair growth

Borbíró, I., Lisztes, E., Tóth, B. I., Czifra, G., Oláh, A., Szöllsi, A. G., Szentandrássy, N., Nánási, P. P., Péter, Z., Paus, R., Kovács, L. & Bíró, T., Aug 2011, In : Journal of Investigative Dermatology. 131, 8, p. 1605-1614 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Adenosine Promotes Human Hair Growth and Inhibits Catagen Transition In Vitro: Role of the Outer Root Sheath Keratinocytes

Lisztes, E., Tóth, B. I., Bertolini, M., Szabó, I. L., Zákány, N., Oláh, A., Szöllősi, A. G., Paus, R. & Bíró, T., May 2020, In : Journal of Investigative Dermatology. 140, 5, p. 1085-1088.e6

Research output: Contribution to journalArticle

1 Scopus citations

A function for Rac1 in the terminal differentiation and pigmentation of hair

Behrendt, K., Klatte, J., Pofahl, R., Bloch, W., Smyth, N., Tscharntke, M., Krieg, T., Paus, R., Niessen, C., Niemann, C., Brakebusch, C. & Haase, I., May 1 2012, In : Development. 139, 9, p. 896-905 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

A guide to studying human Hair follicle cycling in vivo

Oh, J. W., Kloepper, J., Langan, E. A., Kim, Y., Yeo, J., Kim, M. J., Hsi, T. C., Rose, C., Yoon, G. S., Lee, S. J., Seykora, J., Kim, J. C., Sung, Y. K., Kim, M., Paus, R. & Plikus, M. V., Jan 2016, In : Journal of Investigative Dermatology. 136, 1, p. 34-44 11 p.

Research output: Contribution to journalArticle

86 Scopus citations

Alopecia areata as a model for T cell-dependent autoimmune diseases.

Bertolini, M., Gilhar, A. & Paus, R., Jun 2012, In : Experimental dermatology. 21, 6, p. 477-479 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

A meeting of two chronobiological systems: Circadian proteins period1 and bmal1 modulate the human hair cycle clock

Al-Nuaimi, Y., Hardman, J. A., Bíró, T., Haslam, I. S., Philpott, M. P., Tóth, B. I., Farjo, N., Farjo, B., Baier, G., Watson, R. E. B., Grimaldi, B., Kloepper, J. E. & Paus, R., Mar 2014, In : Journal of Investigative Dermatology. 134, 3, p. 610-619 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling

Dobreva, A., Paus, R. & Cogan, N. G., Jan 1 2018, In : Mathematical Medicine and Biology. 35, 3, p. 387-407 21 p.

Research output: Contribution to journalArticle

1 Scopus citations

An efficient method for eccrine gland isolation from human scalp

Jimenez, F., Alam, M., Hernandez, I., Poblet, E., Hardman, J. A. & Paus, R., Jun 1 2018, In : Experimental Dermatology. 27, 6, p. 678-681 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

A neuroendocrinological perspective on human hair follicle pigmentation

Paus, R., Feb 1 2011, In : Pigment Cell and Melanoma Research. 24, 1, p. 89-106 18 p.

Research output: Contribution to journalArticle

32 Scopus citations

An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes

Alam, M., Bertolini, M., Gherardini, J., Keren, A., Ponce, L., Chéret, J., Alenfall, J., Dunér, P., Nilsson, A. H., Gilhar, A. & Paus, R., Jan 1 2019, (Accepted/In press) In : British Journal of Dermatology.

Research output: Contribution to journalArticle

1 Scopus citations

A novel control of human keratin expression: Cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ

Ramot, Y., Sugawara, K., Zákány, N., Tóth, B. I., Bíró, T. & Paus, R., 2013, In : PeerJ. 2013, 1, e40.

Research output: Contribution to journalArticle

26 Scopus citations

A novel in vitro assay for electrophysiological research on human skin fibroblasts: Degenerate electrical waves downregulate collagen I expression in keloid fibroblasts

Sebastian, A., Syed, F., McGrouther, D. A., Colthurst, J., Paus, R. & Bayat, A., Jan 2011, In : Experimental dermatology. 20, 1, p. 64-68 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Antimicrobial peptides (AMPs) from fish epidermis: Perspectives for investigative dermatology

Rakers, S., Niklasson, L., Steinhagen, D., Kruse, C., Schauber, J., Sundell, K. & Paus, R., May 2013, In : Journal of Investigative Dermatology. 133, 5, p. 1140-1149 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

A prototypic mathematical model of the human hair cycle

Al-Nuaimi, Y., Goodfellow, M., Paus, R. & Baier, G., Oct 7 2012, In : Journal of theoretical biology. 310, p. 143-159 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

A role for neuregulin-1 in promoting keloid fibroblast migration via ErbB2-mediated signaling

Jumper, N., Hodgkinson, T., Paus, R. & Bayat, A., Jan 1 2017, In : Acta Dermato-Venereologica. 97, 6, p. 675-684 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

A simple culture method for epithelial stem cells derived from human hair follicle

Hilmi, A. B. M., Halim, A. S., Noor, N. M., Lim, C. K., Idris, Z., Pohchi, A., Asma, H., Wahab, S. F. A., Tiede, S. & Paus, R., Mar 12 2013, In : Central European Journal of Biology. 8, 5, p. 432-439 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Assessment of Quality of Life and Treatment Outcomes of Patients with Persistent Postchemotherapy Alopecia

Freites-Martinez, A., Chan, D., Sibaud, V., Shapiro, J., Fabbrocini, G., Tosti, A., Cho, J., Goldfarb, S., Modi, S., Gajria, D., Norton, L., Paus, R., Cigler, T. & Lacouture, M. E., Jun 2019, In : JAMA dermatology. 155, 6, p. 724-728 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4

Busse, D., Kudella, P., Grüning, N. M., Gisselmann, G., Ständer, S., Luger, T., Jacobsen, F., Steinsträßer, L., Paus, R., Gkogkolou, P., Böhm, M., Hatt, H. & Benecke, H., Nov 5 2014, In : Journal of Investigative Dermatology. 134, 11, p. 2823-2832 10 p.

Research output: Contribution to journalArticle

92 Scopus citations

A technique for more precise distinction between catagen and telogen human hair follicles ex vivo

Hernandez, I., Alam, M., Platt, C., Hardman, J., Smart, E., Poblet, E., Bertolini, M., Paus, R. & Jimenez, F., Sep 2018, In : Journal of the American Academy of Dermatology. 79, 3, p. 558-559 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture

Parodi, C., Hardman, J. A., Allavena, G., Marotta, R., Catelani, T., Bertolini, M., Paus, R. & Grimaldi, B., Mar 1 2018, In : PLoS biology. 16, 3, p. e2002864

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex

Romano, M. T., Tafazzoli, A., Mattern, M., Sivalingam, S., Wolf, S., Rupp, A., Thiele, H., Altmüller, J., Nürnberg, P., Ellwanger, J., Gambon, R., Baumer, A., Kohlschmidt, N., Metze, D., Holdenrieder, S., Paus, R., Lütjohann, D., Frank, J., Geyer, M., Bertolini, M. & 2 others, Kokordelis, P. & Betz, R. C., Nov 1 2018, In : American Journal of Human Genetics. 103, 5, p. 777-785 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Bridging the "dead hair"-"live follicle" divide in applied hair research

Bertolini, M., Botchkareva, N., Westgate, G., Ward, C., Cornwell, P. & Paus, R., Sep 1 2018, In : Journal of Cosmetic Science. 69, 5, p. 315-322 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

Oláh, A., Tóth, B. I., Borbíró, I., Sugawara, K., Szöllõsi, A. G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., Ludovici, M., Picardo, M., Voets, T., Zouboulis, C. C., Paus, R. & Bíró, T., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3713-3724 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

Cannabinoid receptor 1 controls human mucosal-type mast cell degranulation and maturation in situ

Sugawara, K., Zákány, N., Hundt, T., Emelianov, V., Tsuruta, D., Schäfer, C., Kloepper, J. E., Bíró, T. & Paus, R., Jul 2013, In : Journal of Allergy and Clinical Immunology. 132, 1, p. 182-193.e8

Research output: Contribution to journalArticle

29 Scopus citations

Can the hair follicle become a model for studying selected aspects of human ocular immune privilege?

Kinori, M., Kloepper, J. E. & Paus, R., Jun 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 7, p. 4447-4458 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cartilage oligomeric matrix protein (COMP) forms part of the connective tissue of normal human hair follicles

De Schellenberger, A. A., Horland, R., Rosowski, M., Paus, R., Lauster, R. & Lindner, G., Apr 1 2011, In : Experimental dermatology. 20, 4, p. 361-366 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia

Purba, T. S., Ng'andu, K., Brunken, L., Smart, E., Mitchell, E., Hassan, N., O'Brien, A., Mellor, C., Jackson, J., Shahmalak, A. & Paus, R., Oct 1 2019, In : EMBO Molecular Medicine. 11, 10, e11031.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

Purba, T. S., Brunken, L., Peake, M., Shahmalak, A., Chaves, A., Poblet, E., Ceballos, L., Gandarillas, A. & Paus, R., Sep 1 2017, In : European Journal of Cell Biology. 96, 6, p. 632-641 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization of stem cells in Dupuytren's disease

Hindocha, S., Iqbal, S. A., Farhatullah, S., Paus, R. & Bayat, A., Feb 1 2011, In : British Journal of Surgery. 98, 2, p. 308-315 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen–anagen transformation

Hawkshaw, N. J., Hardman, J. A., Alam, M., Jimenez, F. & Paus, R., 2019, (Accepted/In press) In : British Journal of Dermatology.

Research output: Contribution to journalArticle

4 Scopus citations

Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion

Sardella, C., Winkler, C., Quignodon, L., Hardman, J. A., Toffoli, B., Giordano Attianese, G. M. P., Hundt, J. E., Michalik, L., Vinson, C. R., Paus, R., Desvergne, B. & Gilardi, F., Mar 1 2018, In : Journal of Investigative Dermatology. 138, 3, p. 500-510 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis

Fleger-Weckmann, A., Üstün, Y., Kloepper, J., Paus, R., Bloch, W., Chen, Z. L., Wegner, J., Sorokin, L., Langbein, L., Eckes, B., Zigrino, P., Krieg, T. & Nischt, R., Dec 1 2016, In : Matrix Biology. 56, p. 42-56 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal

Foster, A. R., Nicu, C., Schneider, M. R., Hinde, E. & Paus, R., Jul 1 2018, In : Archives of Dermatological Research. 310, 5, p. 453-462 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
22 Scopus citations

Differential expression and functionality of ATP-binding cassette transporters in the human hair follicle

Haslam, I. S., El-Chami, C., Faruqi, H., Shahmalak, A., O'Neill, C. A. & Paus, R., Jun 1 2015, In : British Journal of Dermatology. 172, 6, p. 1562-1572 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Distinct Patterns of Hair Graft Survival After Transplantation Into 2 Nonhealing Ulcers: Is Location Everything?

Alam, M., Cooley, J., Plotczyk, M., Martínez-Martín, M. S., Izeta, A., Paus, R. & Jimenez, F., Apr 1 2019, In : Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 45, 4, p. 557-565 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2

Purba, T. S., Peake, M., Farjo, B., Farjo, N., Bhogal, R. K., Jenkins, G. & Paus, R., Dec 1 2017, In : Scientific Reports. 7, 1, 15197.

Research output: Contribution to journalArticle

10 Scopus citations

Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-) organs?

Carré, J. L., Suzuki, T. & Paus, R., Mar 1 2020, In : Experimental dermatology. 29, 3, p. 357-365 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle?

Nicu, C., Hardman, J. A., Pople, J. & Paus, R., Jan 1 2019, In : Experimental dermatology.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Dopamine is a novel, direct inducer of catagen in human scalp hair follicles in vitro

Langan, E. A., Lisztes, E., Bíro, T., Funk, W., Kloepper, J. E., Griffiths, C. E. M. & Paus, R., Mar 1 2013, In : British Journal of Dermatology. 168, 3, p. 520-525 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

E-Cadherin–Mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis

Xie, G., Ao, X., Lin, T., Zhou, G., Wang, M., Wang, H., Chen, Y., Li, X., Xu, B., He, W., Han, H., Ramot, Y., Paus, R. & Yue, Z., Aug 2017, In : Journal of Investigative Dermatology. 137, 8, p. 1731-1739 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue

Poblet, E., Jimenez, F., Escario-Travesedo, E., Hardman, J. A., Hernández-Hernández, I., Agudo-Mena, J. L., Cabrera-Galvan, J. J., Nicu, C. & Paus, R., May 1 2018, In : British Journal of Dermatology. 178, 5, p. 1163-1172 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endocannabinoids limit excessive mast cell maturation and activation in human skin

Sugawara, K., Bíró, T., Tsuruta, D., Tóth, B. I., Kromminga, A., Zákány, N., Zimmer, A., Funk, W., Gibbs, B. F., Zimmer, A. & Paus, R., Mar 2012, In : Journal of Allergy and Clinical Immunology. 129, 3, p. 726-738.e8

Research output: Contribution to journalArticle

79 Scopus citations

Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1

Tóth, B. I., Dobrosi, N., Dajnoki, A., Czifra, G., Oláh, A., Szöllsi, A. G., Juhász, I., Sugawara, K., Paus, R. & Bíró, T., May 2011, In : Journal of Investigative Dermatology. 131, 5, p. 1095-1104 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Enhanced Neurogenic Biomarker Expression and Reinnervation in Human Acute Skin Wounds Treated by Electrical Stimulation

Sebastian, A., Volk, S. W., Halai, P., Colthurst, J., Paus, R. & Bayat, A., Mar 1 2017, In : Journal of Investigative Dermatology. 137, 3, p. 737-747 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris

Imanishi, H., Ansell, D. M., Chéret, J., Harries, M., Bertolini, M., Sepp, N., Bíró, T., Poblet, E., Jimenez, F., Hardman, J., Panicker, S. P., Ward, C. M. & Paus, R., Mar 2018, In : Journal of Investigative Dermatology. 138, 3, p. 511-519 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Exploring the hair growth-wound healing connection: Anagen phase promotes wound re-Epithelialization

Ansell, D. M., Kloepper, J. E., Thomason, H. A., Paus, R. & Hardman, M. J., Feb 2011, In : Journal of Investigative Dermatology. 131, 2, p. 518-528 11 p.

Research output: Contribution to journalArticle

86 Scopus citations