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  • Ronald Charles Desrosiers
2020

Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys

Fuchs, S. P., Martinez-Navio, J. M., Rakasz, E. G., Gao, G. & Desrosiers, R. C., Mar 13 2020, In : Molecular Therapy - Methods and Clinical Development. 16, p. 94-102 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Rhesus monkey rhadinovirus isolated from hemangioma tissue

Ensser, A., Yasuda, K., Lauer, W., Desrosiers, R. C. & Hahn, A. S., Mar 19 2020, In : Microbiology Resource Announcements. 9, 12, e01347-19.

Research output: Contribution to journalArticle

Open Access
2013

Nonhuman lentiviruses

Evans, D. T., Elder, J. H. & Desrosiers, R. C., May 21 2013, Fields Virology: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations
2012

The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1

Postler, T. S. & Desrosiers, R. C., Feb 16 2012, In : Cell Host and Microbe. 11, 2, p. 181-193 13 p.

Research output: Contribution to journalArticle

49 Scopus citations
2016
32 Scopus citations

Recombinant AAV vectors for enhanced expression of authentic IgG

Fuchs, S. P., Martinez-Navio, J. M., Gao, G. & Desrosiers, R. C., Jun 2016, In : PloS one. 11, 6, e0158009.

Research output: Contribution to journalArticle

11 Scopus citations
2020

Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV

Martinez-Navio, J. M., Fuchs, S. P., Mendes, D. E., Rakasz, E. G., Gao, G., Lifson, J. D. & Desrosiers, R. C., Mar 17 2020, In : Frontiers in immunology. 11, 449.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2016

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

Panico, M., Bouché, L., Binet, D., O'Connor, M. J., Rahman, D., Pang, P. C., Canis, K., North, S. J., Desrosiers, R. C., Chertova, E., Keele, B. F., Bess, J. W., Lifson, J. D., Haslam, S. M., Dell, A. & Morris, H. R., Sep 8 2016, In : Scientific reports. 6, 32956.

Research output: Contribution to journalArticle

40 Scopus citations
2013

Comparative characterization of transfection-and infection-derived simian immunodeficiency virus challenge stocks for In Vivo nonhuman primate studies

Del Prete, G. Q., Scarlotta, M., Newman, L., Reid, C., Parodi, L. M., Roser, J. D., Oswald, K., Marx, P. A., Miller, C. J., Desrosiers, R. C., Barouch, D. H., Pal, R., Piatak, M., Chertova, E., Giavedoni, L. D., O'Connor, D. H., Lifson, J. D. & Keele, B. F., Apr 2013, In : Journal of virology. 87, 8, p. 4584-4595 12 p.

Research output: Contribution to journalArticle

52 Scopus citations
2012

Evidence against extracellular exposure of a highly immunogenic region in the C-terminal domain of the simian immunodeficiency virus gp41 transmembrane protein

Postler, T. S., Martinez-Navio, J. M., Yuste, E. & Desrosiers, R. C., Jan 2012, In : Journal of virology. 86, 2, p. 1145-1157 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Gp120 on HIV-1 virions lacks O-linked carbohydrate

Stansell, E., Panico, M., Canis, K., Pang, P. C., Bouché, L., Binet, D., O'Connor, M. J., Chertova, E., Bess, J., Lifson, J. D., Haslam, S. M., Morris, H. R., Desrosiers, R. C. & Dell, A., Apr 27 2015, In : PloS one. 10, 4, e0124784.

Research output: Contribution to journalArticle

18 Scopus citations
2018

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques

Magnani, D. M., Rogers, T. F., Maness, N. J., Grubaugh, N. D., Beutler, N., Bailey, V. K., Gonzalez-Nieto, L., Gutman, M. J., Pedreño-Lopez, N., Kwal, J. M., Ricciardi, M. J., Myers, T. A., Julander, J. G., Bohm, R. P., Gilbert, M. H., Schiro, F., Aye, P. P., Blair, R. V., Martins, M. A., Falkenstein, K. P. & 12 others, Kaur, A., Curry, C. L., Kallas, E. G., Desrosiers, R. C., Goldschmidt-Clermont, P. J., Whitehead, S. S., Andersen, K. G., Bonaldo, M. C., Lackner, A. A., Panganiban, A. T., Burton, D. R. & Watkins, D. I., Dec 1 2018, In : Nature communications. 9, 1, 1624.

Research output: Contribution to journalArticle

26 Scopus citations
2013

Influence of mismatch of env sequences on vaccine protection by live attenuated simian immunodeficiency virus

Manrique, J., Piatak, M., Lauer, W., Johnson, W., Mansfield, K., Lifson, J. & Desrosiers, R., Jul 1 2013, In : Journal of virology. 87, 13, p. 7246-7254 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

Alpert, M. D., Harvey, J. D., Lauer, W. A., Reeves, R. K., Piatak, M., Carville, A., Mansfield, K. G., Lifson, J. D., Li, W., Desrosiers, R. C., Johnson, R. P. & Evans, D. T., Aug 2012, In : PLoS pathogens. 8, 8, e1002890.

Research output: Contribution to journalArticle

113 Scopus citations
2015

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Gardner, M. R., Kattenhorn, L. M., Kondur, H. R., Von Schaewen, M., Dorfman, T., Chiang, J. J., Haworth, K. G., Decker, J. M., Alpert, M. D., Bailey, C. C., Neale, E. S., Fellinger, C. H., Joshi, V. R., Fuchs, S. P., Martinez-Navio, J. M., Quinlan, B. D., Yao, A. Y., Mouquet, H., Gorman, J., Zhang, B. & 14 others, Poignard, P., Nussenzweig, M. C., Burton, D. R., Kwong, P. D., Piatak, M., Lifson, J. D., Gao, G., Desrosiers, R. C., Evans, D. T., Hahn, B. H., Ploss, A., Cannon, P. M., Seaman, M. S. & Farzan, M., Mar 5 2015, In : Nature. 519, 7541, p. 87-91 5 p.

Research output: Contribution to journalArticle

173 Scopus citations
2013
21 Scopus citations
2016

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

Adnan, S., Reeves, R. K., Gillis, J., Wong, F. E., Yu, Y., Camp, J. V., Li, Q., Connole, M., Li, Y., Piatak, M., Lifson, J. D., Li, W., Keele, B. F., Kozlowski, P. A., Desrosiers, R. C., Haase, A. T. & Johnson, R. P., Dec 13 2016, In : PLoS pathogens. 12, 12, e1006104.

Research output: Contribution to journalArticle

16 Scopus citations
2020

Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies

Silver, Z. A., Antonopoulos, A., Haslam, S. M., Dell, A., Dickinson, G. M., Seaman, M. S. & Desrosiers, R. C., Feb 11 2020, In : Cell Reports. 30, 6, p. 1862-1869.e4

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products

Shin, Y. C., Bischof, G. F., Lauer, W. A., Gonzalez-Nieto, L., Rakasz, E. G., Hendricks, G. M., Watkins, D. I., Martins, M. A. & Desrosiers, R. C., Jun 2018, In : PLoS pathogens. 14, 6, e1007143.

Research output: Contribution to journalArticle

6 Scopus citations
2020

A recombinant rhesus monkey rhadinovirus deleted of glycoprotein L establishes persistent infection of rhesus macaques and elicits conventional T cell responses

Hahn, A. S., Bischof, G. F., Großkopf, A. K., Shin, Y. C., Domingues, A., Gonzalez-Nieto, L., Rakasz, E. G., Watkins, D. I., Ensser, A., Martins, M. A. & Desrosiers, R. C., Jan 1 2020, In : Journal of virology. 94, 2, e01093-19.

Research output: Contribution to journalArticle

2015

Host Anti-antibody Responses Following Adeno-associated Virus–mediated Delivery of Antibodies Against HIV and SIV in Rhesus Monkeys

Martinez-Navio, J. M., Fuchs, S. P., Pedreño-López, S., Rakasz, E. G., Gao, G. & Desrosiers, R. C., Oct 7 2015, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

36 Scopus citations
2016

Magnitude and quality of cytokine and chemokine storm during acute infection distinguish nonprogressive and progressive simian immunodeficiency virus infections of nonhuman primates

Keating, S. M., Heitman, J. W., Wu, S., Deng, X., Stacey, A. R., Zahn, R. C., de la Rosa, M., Finstad, S. L., Lifson, J. D., Piatak, M., Gauduin, M. C., Kessler, B. M., Ternette, N., Carville, A., Johnson, R. P., Desrosiers, R. C., Letvin, N. L., Borrow, P., Norris, P. J. & Schmitz, J. E., 2016, In : Journal of virology. 90, 22, p. 10339-10350 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012
5 Scopus citations
2018

With differences in acute viremia in simian immunodeficiency virus δnef-infected animals

Janaka, S. K., Tavakoli-Tameh, A., Neidermyer, W. J., Serra-Moreno, R., Hoxie, J. A., Desrosiers, R. C., Paul Johnson, R., Lifson, J. D., Wolinsky, S. M. & Evans, D. T., Nov 1 2018, In : Journal of virology. 92, 22, e00542.

Research output: Contribution to journalArticle

3 Scopus citations

Mamu-B*17+ rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication

Martins, M. A., Tully, D. C., Pedreño-Lopez, N., Bredow, B. V., Pauthner, M. G., Shin, Y. C., Yuan, M., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Altman, J. D., Burton, D. R., Ejima, K., Allison, D. B. & 9 others, Evans, D. T., Rakasz, E. G., Parks, C. L., Bonaldo, M. C., Capuano, S., Lifson, J. D., Desrosiers, R. C., Allen, T. M. & Watkins, D. I., Aug 1 2018, In : Journal of virology. 92, 16, e00690-18.

Research output: Contribution to journalArticle

3 Scopus citations
2013

The tale of the long tail: The cytoplasmic domain of HIV-1 gp41

Postler, T. S. & Desrosiers, R. C., Jan 2013, In : Journal of virology. 87, 1, p. 2-15 14 p.

Research output: Contribution to journalShort survey

65 Scopus citations
2015

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

Fuchs, S. P., Martinez-Navio, J. M., Piatak, M., Lifson, J. D., Gao, G. & Desrosiers, R. C., Aug 1 2015, In : PLoS pathogens. 11, 8, e1005090.

Research output: Contribution to journalArticle

49 Scopus citations
2018

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi’s sarcoma-associated herpesvirus and rhesus monkey rhadinovirus

Großkopf, A. K., Ensser, A., Neipel, F., Jungnickl, D., Schlagowski, S., Desrosiers, R. C. & Hahn, A. S., Feb 2018, In : PLoS pathogens. 14, 2, e1006912.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Importance of codon usage for the temporal regulation of viral gene expression

Shin, Y. C., Bischof, G. F., Lauer, W. A. & Desrosiers, R. C., Nov 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 14030-14035 6 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
2016

Cellular immune responses against simian T-lymphotropic virus type 1 target Tax in infected baboons

Castro, I., Giret, T. M., Magnani, D. M., Maxwell, H. S., Umland, O., Perry, J. K., Pecotte, J. K., Brasky, K. M., Barber, G. N., Desrosiers, R. C. & Watkins, D. I., Jun 1 2016, In : Journal of virology. 90, 11, p. 5280-5291 12 p.

Research output: Contribution to journalArticle

4 Scopus citations