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  • Claes R Wahlestedt
2016

Altering the course of schizophrenia: progress and perspectives

Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., Kahn, R., Krebs, M. O., Leboyer, M., Lewis, D., Marin, O., Marin, P., Meyer-Lindenberg, A., McGorry, P., McGuire, P., Owen, M. J. & 7 others, Patterson, P., Sawa, A., Spedding, M., Uhlhaas, P., Vaccarino, F., Wahlestedt, C. R. & Weinberger, D., Mar 4 2016, (Accepted/In press) In : Nature Reviews Drug Discovery.

Research output: Contribution to journalArticle

152 Scopus citations

The BET-bromodomain inhibitor JQ1 reduces inflammation and tau phosphorylation at ser396 in the brain of the 3xTg model of Alzheimer’s disease

Magistri, M., Velmeshev, D., Makhmutova, M., Patel, P., Sartor, G., Volmar, C. H., Wahlestedt, C. R. & Faghihi, M. A., Sep 1 2016, In : Current Alzheimer Research. 13, 9, p. 985-995 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients

Esanov, R., Andrade, N. S., Bennison, S., Wahlestedt, C. R. & Zeier, Z. R., Nov 15 2016, In : Human Molecular Genetics. 25, 22, p. 4870-4880 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs

Plotkin, A., Volmar, C. H., Wahlestedt, C. R., Ayad, N. & El-Ashry, D., Sep 1 2014, In : Breast Cancer Research and Treatment. 147, 2, p. 249-263 15 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Basic biology and therapeutic implications of lncRNA

Khorkova, O., Hsiao, J. & Wahlestedt, C. R., Jun 29 2015, In : Advanced Drug Delivery Reviews. 87, p. 15-24 10 p.

Research output: Contribution to journalArticle

109 Scopus citations
2019

HDAC Inhibitors Induce BDNF Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons

Bagheri, A., Habibzadeh, P., Razavipour, S. F., Volmar, C. H., Chee, N. T., Brothers, S. P., Wahlestedt, C. R., Mowla, S. J. & Faghihi, M. A., Mar 5 2019, In : International journal of molecular sciences. 20, 5

Research output: Contribution to journalArticle

Open Access

Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer

Mustafi, S., Camarena, V., Qureshi, R., Yoon, H., Volmar, C. H., Huff, T. C., Sant, D. W., Zheng, L., Brothers, S. P., Wahlestedt, C., Slingerland, J. & Wang, G., Jan 1 2019, In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2016

MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps

Khomtchouk, B. B., Hennessy, J. R. & Wahlestedt, C. R., Sep 22 2016, In : BMC Bioinformatics. 17, 1, 390.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Screening for small-molecule modulators of long noncoding RNA-protein interactions using alphascreen

Pedram Fatemi, R., Salah-Uddin, S., Modarresi, F., Khoury, N., Wahlestedt, C. R. & Faghihi, M. A., Oct 22 2015, In : Journal of Biomolecular Screening. 20, 9, p. 1132-1141 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2013

Personalized medicine in psychiatry: Problems and promises

Ozomaro, U., Wahlestedt, C. & Nemeroff, C. B., May 16 2013, In : BMC Medicine. 11, 1, 132.

Research output: Contribution to journalReview article

109 Scopus citations
2018

EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia

Johnstone, A. L., O'Reilly, J. J., Patel, A. J., Guo, Z., Andrade, N. S., Magistri, M., Nathanson, L., Esanov, R., Miller, B. H., Turecki, G., Brothers, S. P., Zeier, Z. R. & Wahlestedt, C. R., Nov 1 2018, In : Neurobiology of Disease. 119, p. 149-158 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Reprogramming of mPFC transcriptome and function in alcohol dependence

Heilig, M., Barbier, E., Johnstone, A. L., Tapocik, J., Meinhardt, M. W., Pfarr, S., Wahlestedt, C. R. & Sommer, W. H., Jan 1 2017, In : Genes, Brain and Behavior. 16, 1, p. 86-100 15 p.

Research output: Contribution to journalReview article

19 Scopus citations
2014

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

Peschansky, V. J. & Wahlestedt, C., Jan 1 2014, In : Epigenetics. 9, 1, p. 3-12 10 p.

Research output: Contribution to journalReview article

202 Scopus citations
2015

Extracellular Uridine Triphosphate and Adenosine Triphosphate Attenuate Endothelial Inflammation through miR-22-Mediated ICAM-1 Inhibition

Gidlöf, O., Sathanoori, R., Magistri, M., Faghihi, M. A., Wahlestedt, C. R., Olde, B. & Erlinge, D., Jun 13 2015, (Accepted/In press) In : Journal of Vascular Research. p. 71-80 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2014

I-BET151 selectively regulates IL-6 production

Barrett, E., Brothers, S., Wahlestedt, C. & Beurel, E., Sep 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 9, p. 1549-1555 7 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

Targeting long non-coding RNA to therapeutically upregulate gene expression

Wahlestedt, C., Jun 1 2013, In : Nature Reviews Drug Discovery. 12, 6, p. 433-446 14 p.

Research output: Contribution to journalReview article

286 Scopus citations
2016

Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome

Hsiao, J., Yuan, T. Y., Tsai, M. S., Lu, C. Y., Lin, Y. C., Lee, M. L., Lin, S. W., Chang, F. C., Liu Pimentel, H., Olive, C., Coito, C., Shen, G., Young, M., Thorne, T., Lawrence, M., Magistri, M., Faghihi, M. A., Khorkova, O. & Wahlestedt, C. R., Apr 7 2016, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

30 Scopus citations
2019

Longevity-related molecular pathways are subject to midlife “switch” in humans

Timmons, J. A., Volmar, C. H., Crossland, H., Phillips, B. E., Sood, S., Janczura, K. J., Törmäkangas, T., Kujala, U. M., Kraus, W. E., Atherton, P. J. & Wahlestedt, C. R., Aug 1 2019, In : Aging Cell. 18, 4, e12970.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2016

Functional annotation of the vlinc class of non-coding RNAs using systems biology approach

Laurent, G. S., Vyatkin, Y., Antonets, D., Ri, M., Qi, Y., Saik, O., Shtokalo, D., De Hoon, M. J. L., Kawaji, H., Itoh, M., Lassmann, T., Arner, E., Forrest, A. R. R., Nicolas, E., McCaffrey, T. A., Carninci, P., Hayashizaki, Y., Wahlestedt, C. R. & Kapranov, P., Mar 21 2016, In : Nucleic Acids Research. 44, 7, p. 3233-3252 20 p.

Research output: Contribution to journalArticle

16 Scopus citations
2018

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

Timmons, J. A., Atherton, P. J., Larsson, O., Sood, S., Blokhin, I. O., Brogan, R. J., Volmar, C. H., Josse, A. R., Slentz, C., Wahlestedt, C. R., Phillips, S. M., Phillips, B. E., Gallagher, I. J. & Kraus, W. E., Jan 1 2018, In : Nucleic Acids Research. 46, 15, p. 7772-7792 21 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Bromodomain inhibitors regulate the C9ORF72 locus in ALS

Zeier, Z. R., Esanov, R., Belle, K. C., Volmar, C. H., Johnstone, A. L., Halley, P., DeRosa, B. A., Khoury, N., van Blitterswijk, M., Rademakers, R., Albert, J., Brothers, S. P., Wuu, J., Dykxhoorn, D. M., Benatar, M. G. & Wahlestedt, C. R., Sep 1 2015, In : Experimental Neurology. 271, p. 241-250 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans

Peschansky, V. J., Pastori, C., Zeier, Z. R., Wentzel, K., Velmeshev, D., Magistri, M., Silva, J. P. & Wahlestedt, C. R., Jul 1 2016, In : Molecular and Cellular Neuroscience. 74, p. 49-57 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring

Silva, J. P., Lambert, G., van Booven, D. & Wahlestedt, C. R., Sep 8 2016, In : Genome Medicine. 8, 1, 93.

Research output: Contribution to journalArticle

5 Scopus citations
2019

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Argemi, J., Latasa, M. U., Atkinson, S. R., Blokhin, I. O., Massey, V., Gue, J. P., Cabezas, J., Lozano, J. J., Van Booven, D., Bell, A., Cao, S., Vernetti, L. A., Arab, J. P., Ventura-Cots, M., Edmunds, L. R., Fondevilla, C., Stärkel, P., Dubuquoy, L., Louvet, A., Odena, G. & 20 others, Gomez, J. L., Aragon, T., Altamirano, J., Caballeria, J., Jurczak, M. J., Taylor, D. L., Berasain, C., Wahlestedt, C. R., Monga, S. P., Morgan, M. Y., Sancho-Bru, P., Mathurin, P., Furuya, S., Lackner, C., Rusyn, I., Shah, V. H., Thursz, M. R., Mann, J., Avila, M. A. & Bataller, R., Dec 1 2019, In : Nature communications. 10, 1, 3126.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2016

Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice

Sartor, G., Powell, S. K., Wiedner, H. J., Wahlestedt, C. R. & Brothers, S. P., Feb 1 2016, In : Brain Research. 1632, p. 34-41 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

The reality of pervasive transcription

Clark, M. B., Amaral, P. P., Schlesinger, F. J., Dinger, M. E., Taft, R. J., Rinn, J. L., Ponting, C. P., Stadler, P. F., Morris, K. V., Morillon, A., Rozowsky, J. S., Gerstein, M. B., Wahlestedt, C., Hayashizaki, Y., Carninci, P., Gingeras, T. R. & Mattick, J. S., Jul 1 2011, In : PLoS biology. 9, 7, e1000625.

Research output: Contribution to journalArticle

276 Scopus citations
2014

Natural antisense transcripts

Khorkova, O., Myers, A. J., Hsiao, J. & Wahlestedt, C., Sep 2014, In : Human molecular genetics. 23, R1, p. R54-R63

Research output: Contribution to journalReview article

59 Scopus citations
2018

Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls

Cao, H., Wahlestedt, C. R. & Kapranov, P., Jan 1 2018, (Accepted/In press) In : Trends in Genetics.

Research output: Contribution to journalArticle

15 Scopus citations
2017

M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory

Volmar, C. H., Salah-Uddin, H., Janczura, K. J., Halley, P., Lambert, G., Wodrich, A., Manoah, S., Patel, N. H., Sartor, G., Mehta, N., Miles, N. T. H., Desse, S., Dorcius, D., Cameron, M. D., Brothers, S. P. & Wahlestedt, C. R., Oct 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. E9135-E9144

Research output: Contribution to journalArticle

12 Scopus citations
2019

CHAPTER 9: Oligonucleotide Targeting of Long Non-coding RNAs

Blokhin, I., Khorkova, O., Hsiao, J. & Wahlestedt, C. R., Jan 1 2019, Therapies for Retinal Degeneration: Targeting Common Processes. Agrawal, S. & Gait, M. J. (eds.). 68 ed. Royal Society of Chemistry, p. 181-205 25 p. (RSC Drug Discovery Series; vol. 2019-January, no. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Purification of H3 and H4 histone proteins and the quantification of acetylated histone marks in cells and brain tissue

Janczura, K. J., Volmar, C. H. & Wahlestedt, C. R., Nov 1 2018, In : Journal of Visualized Experiments. 2018, 141, e58648.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics

Khomtchouk, B. B., Hennessy, J. R. & Wahlestedt, C. R., May 1 2017, In : PLoS One. 12, 5, e0176334.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Antisense RNA Controls LRP1 Sense Transcript Expression through Interaction with a Chromatin-Associated Protein, HMGB2

Yamanaka, Y., Faghihi, M. A., Magistri, M., Alvarez-Garcia, O., Lotz, M. & Wahlestedt, C. R., May 12 2015, In : Cell Reports. 11, 6, p. 967-976 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2018

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma

Lohse, I., Al-Ali, H., Volmar, C. H., Alvarez Trotta, A. D., Brothers, S. P., Capobianco, A. J. & Wahlestedt, C. R., Sep 1 2018, In : PLoS One. 13, 9, e0203173.

Research output: Contribution to journalArticle

2019

Optimized functional annotation of ChIP-seq data [version 1; peer review: 3 approved with reservations]

Khomtchouk, B. B., Koehler, W. C., Van Booven, D. J. & Wahlestedt, C., Jan 1 2019, In : F1000Research. 8, 612.

Research output: Contribution to journalArticle

Open Access
2015

Histone deacetylases (HDACs) and brain function

Volmar, C. H. & Wahlestedt, C. R., 2015, In : Neuroepigenetics. 1, p. 20-27 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
2017

Oligonucleotide therapies for disorders of the nervous system

Khorkova, O. & Wahlestedt, C. R., Mar 1 2017, In : Nature Biotechnology. 35, 3, p. 249-263 15 p.

Research output: Contribution to journalArticle

42 Scopus citations

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

Esanov, R., Cabrera, G. T., Andrade, N. S., Gendron, T. F., Brown, R. H., Benatar, M. G., Wahlestedt, C. R., Mueller, C. & Zeier, Z. R., Jun 12 2017, In : Molecular Neurodegeneration. 12, 1, 46.

Research output: Contribution to journalArticle

6 Scopus citations

Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets

Wahlestedt, C. R., Jan 1 2017, In : Neuropsychopharmacology. 42, 1, p. 374-375 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations
2016

Seltene Krankheiten: Aktueller Stand der Pharmaforschung

Translated title of the contribution: Orphan diseases: state of the drug discovery artVolmar, C. H., Wahlestedt, C. R. & Brothers, S. P., Jan 27 2016, (Accepted/In press) In : Wiener Medizinische Wochenschrift. p. 1-8 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014
19 Scopus citations
2015

Epigenetic readers of lysine acetylation regulate cocaine-induced plasticity

Sartor, G., Powell, S. K., Brothers, S. P. & Wahlestedt, C. R., Nov 11 2015, In : Journal of Neuroscience. 35, 45, p. 15062-15072 11 p.

Research output: Contribution to journalArticle

29 Scopus citations
2018

Cocaine exposure increases blood pressure and aortic stiffness via the mir-30c-5p-malic enzyme 1-reactive oxygen species pathway

Zhu, W., Wang, H., Wei, J., Sartor, G., Bao, M. M., Pierce, C. T., Wahlestedt, C. R., Dykxhoorn, D. M. & Dong, C., Jan 1 2018, In : Hypertension. 71, 4, p. 752-760 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Emerging treatment strategies for glioblastoma multiforme

Carlsson, S. K., Brothers, S. P. & Wahlestedt, C., Nov 1 2014, In : EMBO Molecular Medicine. 6, 11, p. 1359-1370 12 p.

Research output: Contribution to journalReview article

104 Scopus citations
2016

Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2

Barbier, E., Johnstone, A. L., Khomtchouk, B. B., Tapocik, J. D., Pitcairn, C., Rehman, F., Augier, E., Borich, A., Schank, J. R., Rienas, C. A., van Booven, D. J., Sun, H., Nätt, D., Wahlestedt, C. R. & Heilig, M., Aug 30 2016, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

15 Scopus citations

Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation

Gidlöf, O., Johnstone, A. L., Bader, K., Khomtchouk, B. B., O'Reilly, J. J., Celik, S., Van Booven, D. J., Wahlestedt, C. R., Metzler, B. & Erlinge, D., Dec 1 2016, In : Journal of the American Heart Association. 5, 12, e004076.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Involvement of long noncoding RNAs in diseases affecting the central nervous system

Pastori, C. & Wahlestedt, C., Jun 2012, In : RNA Biology. 9, 6, p. 860-870 11 p.

Research output: Contribution to journalReview article

65 Scopus citations

RNAi joins the singles club

Peschansky, V. J., Liang, Z. & Wahlestedt, C., Nov 1 2012, In : Molecular Therapy. 20, 11, p. 2010-2011 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2015

The bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

Pastori, C., Kapranov, P., Penas, C., Peschansky, V., Volmar, C. H., Sarkaria, J. N., Bregy, A., Komotar, R. J., Laurent, G. S., Ayad, N., Wahlestedt, C. R. & Roberts, T. C., Jul 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8326-8331 6 p.

Research output: Contribution to journalArticle

96 Scopus citations
2012

The emerging role of non-coding RNAs in drug addiction

Sartor, G. C., St. Laurent, G. & Wahlestedt, C., Dec 1 2012, In : Frontiers in Genetics. 3, JUN, Article 106.

Research output: Contribution to journalArticle

40 Scopus citations