[8 HOMOARGININ](LUTENISIERENDES HORMON FREISETZENDES HORMON)

Translated title of the contribution: [8 Homoarginine]luteinizing hormone releasing hormone

R. Geiger, W. Koenig, J. Sandow, Andrew V Schally

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Abstract

The synthesis and LH releasing activity of [8 homoarginine] LH RH are described. Its biological activity is discussed in relation to that of other analogues with substitutions in position 8. Although in homoarginine the positive charge of the guanidino group of arginine is only displaced by 1.54 A, the LH releasing activity is reduced to 20% of that of LH RH. There is a surprising analogy with ACTH. Replacing 8 arginine by Å ornithine, or homoarginine, nearly the same decrease in the biological activity has been found as with the correpsonding analogues of LH RH.

Translated title of the contribution[8 Homoarginine]luteinizing hormone releasing hormone
Original languageGerman
Title of host publicationHOPPE-SEYLER'S Z.PHYSIOL.CHEM.
Pages1526-1534
Number of pages9
Volume355
Edition12
StatePublished - Dec 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Geiger, R., Koenig, W., Sandow, J., & Schally, A. V. (1974). [8 HOMOARGININ](LUTENISIERENDES HORMON FREISETZENDES HORMON). In HOPPE-SEYLER'S Z.PHYSIOL.CHEM. (12 ed., Vol. 355, pp. 1526-1534)