[8 HOMOARGININ](LUTENISIERENDES HORMON FREISETZENDES HORMON)

Translated title of the contribution: [8 Homoarginine]luteinizing hormone releasing hormone

R. Geiger, W. Koenig, J. Sandow, Andrew V Schally

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

The synthesis and LH releasing activity of [8 homoarginine] LH RH are described. Its biological activity is discussed in relation to that of other analogues with substitutions in position 8. Although in homoarginine the positive charge of the guanidino group of arginine is only displaced by 1.54 A, the LH releasing activity is reduced to 20% of that of LH RH. There is a surprising analogy with ACTH. Replacing 8 arginine by Å ornithine, or homoarginine, nearly the same decrease in the biological activity has been found as with the correpsonding analogues of LH RH.

Original languageGerman
Title of host publicationHOPPE-SEYLER'S Z.PHYSIOL.CHEM.
Pages1526-1534
Number of pages9
Volume355
Edition12
StatePublished - Dec 1 1974
Externally publishedYes

Fingerprint

Homoarginine
Gonadotropin-Releasing Hormone
Arginine
Ornithine
Adrenocorticotropic Hormone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Geiger, R., Koenig, W., Sandow, J., & Schally, A. V. (1974). [8 HOMOARGININ](LUTENISIERENDES HORMON FREISETZENDES HORMON). In HOPPE-SEYLER'S Z.PHYSIOL.CHEM. (12 ed., Vol. 355, pp. 1526-1534)

[8 HOMOARGININ](LUTENISIERENDES HORMON FREISETZENDES HORMON). / Geiger, R.; Koenig, W.; Sandow, J.; Schally, Andrew V.

HOPPE-SEYLER'S Z.PHYSIOL.CHEM.. Vol. 355 12. ed. 1974. p. 1526-1534.

Research output: Chapter in Book/Report/Conference proceedingChapter

Geiger, R, Koenig, W, Sandow, J & Schally, AV 1974, [8 HOMOARGININ](LUTENISIERENDES HORMON FREISETZENDES HORMON). in HOPPE-SEYLER'S Z.PHYSIOL.CHEM.. 12 edn, vol. 355, pp. 1526-1534.
Geiger R, Koenig W, Sandow J, Schally AV. [8 HOMOARGININ](LUTENISIERENDES HORMON FREISETZENDES HORMON). In HOPPE-SEYLER'S Z.PHYSIOL.CHEM.. 12 ed. Vol. 355. 1974. p. 1526-1534
Geiger, R. ; Koenig, W. ; Sandow, J. ; Schally, Andrew V. / [8 HOMOARGININ](LUTENISIERENDES HORMON FREISETZENDES HORMON). HOPPE-SEYLER'S Z.PHYSIOL.CHEM.. Vol. 355 12. ed. 1974. pp. 1526-1534
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