7-OH-DPAT antagonizes dopamine D2 receptor-inhibited adenylyl cyclase activity

Sari E Izenwasser, Jonathan L. Katz

Research output: Contribution to journalArticle

Abstract

(±)7-OH-DPAT (7-hydroxy-2-(di-n-propylamino) tetralin) binds to both dopamine D2 and D3 receptor subtypes. In 7315c pituitary tumor cell membranes, which express only the D2 type of dopamine receptor, dopamine inhibited, and 7-OH-DPAT had no effect on adenylyl cyclase activity. When combined, 7-OH-DPAT antagonized the inhibition of adenylyl cyclase produced by dopamine. Thus, it appears that 7-OH-DPAT acts as an antagonist at dopamine D2 receptors.

Original languageEnglish
JournalLife Sciences
Volume55
Issue number14
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Dopamine D2 Receptors
Adenylyl Cyclases
Dopamine
Dopamine D3 Receptors
Pituitary Neoplasms
Cell membranes
Tumors
Cell Membrane
hydroxide ion
7-hydroxy-2-N,N-dipropylaminotetralin

Keywords

  • 7-OH-DPAT
  • adenylyl cyclase
  • dopamine D receptors

ASJC Scopus subject areas

  • Pharmacology

Cite this

7-OH-DPAT antagonizes dopamine D2 receptor-inhibited adenylyl cyclase activity. / Izenwasser, Sari E; Katz, Jonathan L.

In: Life Sciences, Vol. 55, No. 14, 01.01.1994.

Research output: Contribution to journalArticle

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AB - (±)7-OH-DPAT (7-hydroxy-2-(di-n-propylamino) tetralin) binds to both dopamine D2 and D3 receptor subtypes. In 7315c pituitary tumor cell membranes, which express only the D2 type of dopamine receptor, dopamine inhibited, and 7-OH-DPAT had no effect on adenylyl cyclase activity. When combined, 7-OH-DPAT antagonized the inhibition of adenylyl cyclase produced by dopamine. Thus, it appears that 7-OH-DPAT acts as an antagonist at dopamine D2 receptors.

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