7-OH-DPAT antagonizes dopamine D2 receptor-inhibited adenylyl cyclase activity

Sari Izenwasser, Jonathan L. Katz

Research output: Contribution to journalArticle

Abstract

(±)7-OH-DPAT (7-hydroxy-2-(di-n-propylamino) tetralin) binds to both dopamine D2 and D3 receptor subtypes. In 7315c pituitary tumor cell membranes, which express only the D2 type of dopamine receptor, dopamine inhibited, and 7-OH-DPAT had no effect on adenylyl cyclase activity. When combined, 7-OH-DPAT antagonized the inhibition of adenylyl cyclase produced by dopamine. Thus, it appears that 7-OH-DPAT acts as an antagonist at dopamine D2 receptors.

Original languageEnglish (US)
Pages (from-to)PL257-PL259
JournalLife Sciences
Volume55
Issue number14
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • 7-OH-DPAT
  • adenylyl cyclase
  • dopamine D receptors

ASJC Scopus subject areas

  • Pharmacology

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