5HTTLPR predicts left fusiform gyrus activation to positive emotional stimuli

Heath A. Demaree, Jie Pu, Jack Jesberger, Norah Feeny, Linda Jeng, D. Erik Everhart, Jeff Duerk, Jean Tkach

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


This study was designed to replicate and extend past research examining the impact of the serotonin transporter gene-linked polymorphic region (5HTTLPR) on neural activation during emotional processing. Six women with at least one short allele were compared to six age-matched women with long/long alleles of the 5HTTLPR. Participants were shown 36 positive and 36 negative slides from the International Affective Picture Set, while functional images were acquired using a 4-T magnetic resonance imaging scanner. Although we were unable to replicate past research demonstrating relatively increased amygdala activation among individuals with an "s" allele to negative stimuli, women with an s allele evidenced decreased left fusiform gyrus activation to positive emotional stimuli (as expected). We suggest that women with a short allele may be either less attentive or less "expert" with regard to positive emotional stimuli, and ideas for future research are presented.

Original languageEnglish (US)
Pages (from-to)441-448
Number of pages8
JournalMagnetic Resonance Imaging
Issue number4
StatePublished - May 2009
Externally publishedYes


  • Anxiety
  • Depression
  • Emotion
  • fMRI
  • Processing

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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