5‐HALOGENATED ANALOGS OF DEOXYCYTIDINE AS SELECTIVE INHIBITORS OF THE REPLICATION OF HERPES SIMPLEX VIRUSES IN CELL CULTURE AND RELATED STUDIES OF INTRACRANIAL HERPES SIMPLEX VIRUS INFECTIONS IN MICE

Sheldon Greer, Ira Schildkraut, Thom Zimmerman, Herbert Kaufman

Research output: Contribution to journalArticle

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Abstract

Selective inhibition of Herpes simplex virus replication has been demonstrated in studies with cell culture. In the present study a significant fraction of mice survived intracranial infection of HSV, with bromodeoxycytidine and tetrahydrouridine therapy. Together, these studies suggest that the 5 halogenated analogs of deoxycytidine in combination with tethydrouridine have potential as effective agents in the therapy of herpes encephalitis as well as other herpes simplex virus infections.

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume255
Issue number1
DOIs
StatePublished - Aug 1975

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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