5a-Pregnane-3a,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam

Michael J. Owens, James C. Ritchie, Charles Nemeroff

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

5α-Pregnane-3α,21-diol-20-one (THDOC; 5 mg/kg) and the triazolobenzodiazepine alprazolam (1 mg/kg) attenuated mild stress-induced increase in plasma corticosterone concentrations via GABAergic mechanisms. Unlike alprazolam, THDOC failed to decrease corticotropin-releasing factor (CRF) concentrations in the locus ceruleus. While THDOC may plausibly act via endogenous GABAergic mechanisms to reduce stress-induced endocrine and behavioral responses that are likely mediated in part by CRF neurons, these preliminary findings suggest that, at the dose and time point studied, THDOC does not identically mimic the actions of alprazolam, another drug which potentiates GABAergiv activity.

Original languageEnglish
Pages (from-to)353-355
Number of pages3
JournalBrain Research
Volume573
Issue number2
DOIs
StatePublished - Feb 28 1992
Externally publishedYes

Fingerprint

Alprazolam
Pregnanes
Corticosterone
Corticotropin-Releasing Hormone
Locus Coeruleus
tetrahydrodeoxycorticosterone
Neurons
Pharmaceutical Preparations

Keywords

  • Alprazolam
  • Corticosterone
  • Corticotropin-releasing factor
  • GABAergic
  • Neuroendocrine
  • Steroid metabolite
  • Tetrahydrodeoxycorticosterone

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

5a-Pregnane-3a,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism : comparison with alprazolam. / Owens, Michael J.; Ritchie, James C.; Nemeroff, Charles.

In: Brain Research, Vol. 573, No. 2, 28.02.1992, p. 353-355.

Research output: Contribution to journalArticle

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