5 Halogenated analogs of deoxycytidine as selective inhibitors of the replication of herpes simplex viruses in cell culture and related studies of intracranial herpes simplex virus infections in mice

S. Greer, I. Schildkraut, T. Zimmerman, H. Kaufman

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Selective inhibition of Herpes simplex virus replication has been demonstrated in studies with cell culture. In the present study a significant fraction of mice survived intracranial infection of HSV, with bromodeoxycytidine and tetrahydrouridine therapy. Together, these studies suggest that the 5 halogenated analogs of deoxycytidine in combination with tethydrouridine have potential as effective agents in the therapy of herpes encephalitis as well as other herpes simplex virus infections.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volumevol.255
StatePublished - Dec 1 1975
Externally publishedYes

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Deoxycytidine
Virus Diseases
Simplexvirus
Viruses
Cell culture
Bromodeoxycytidine
Tetrahydrouridine
Cell Culture Techniques
Herpes Simplex Encephalitis
Virus Replication
Therapeutics
Infection
Virus
Therapy
Mouse
Replication
Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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