Abstract
5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses. Twenty-seven (79%) of the 34 aphakic eyes with glaucoma achieved an intraocular pressure (IOP) of ≤21 mmHg (range of follow-up on nonreoperated eyes, 91-468 days). Nine (69%) of 13 eyes with neovascular glaucoma achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 120-379 days). Eight (89%) of nine phakic eyes with glaucoma following unsuccessful filtering procedures achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 134-394 days). Visual acuities remained within one line of their preoperative levels or improved in 32 (94%) of the 34 aphakic eyes with glaucoma, eight (62%) of the 13 eyes with neovascular glaucoma, and six (67%) of the nine phakic eyes with glaucoma following unsuccessful filtering procedures. Postoperative corneal epithelial defects occurred in 45% of the cases. Conjunctival wound and conjunctival needle tract leaks were observed in 41% of the cases, but only one eye required wound revision. No other serious side effects that we attributed to 5-FU were observed. It seems that postoperative subconjunctival 5-FU increases the likelihood of achieving IOP control following filtering surgery in eyes with poor surgical prognoses; however, a randomized clinical trial is necessary to confirm this.
Original language | English (US) |
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Pages (from-to) | 384-394 |
Number of pages | 11 |
Journal | Ophthalmology |
Volume | 91 |
Issue number | 4 |
DOIs | |
State | Published - 1984 |
Keywords
- 5-fluorouracil
- filtering surgery
- glaucoma following unsuccessful filtering surgery
- glaucoma in aphakia
- glaucoma surgery
- neovascular glaucoma
ASJC Scopus subject areas
- Ophthalmology