5-Fluorouracil and glaucoma filtering surgery. II. A pilot study

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Abstract

5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses. Twenty-seven (79%) of the 34 aphakic eyes with glaucoma achieved an intraocular pressure (IOP) of ≤21 mmHg (range of follow-up on nonreoperated eyes, 91-468 days). Nine (69%) of 13 eyes with neovascular glaucoma achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 120-379 days). Eight (89%) of nine phakic eyes with glaucoma following unsuccessful filtering procedures achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 134-394 days). Visual acuities remained within one line of their preoperative levels or improved in 32 (94%) of the 34 aphakic eyes with glaucoma, eight (62%) of the 13 eyes with neovascular glaucoma, and six (67%) of the nine phakic eyes with glaucoma following unsuccessful filtering procedures. Postoperative corneal epithelial defects occurred in 45% of the cases. Conjunctival wound and conjunctival needle tract leaks were observed in 41% of the cases, but only one eye required wound revision. No other serious side effects that we attributed to 5-FU were observed. It seems that postoperative subconjunctival 5-FU increases the likelihood of achieving IOP control following filtering surgery in eyes with poor surgical prognoses; however, a randomized clinical trial is necessary to confirm this.

Original languageEnglish
Pages (from-to)384-394
Number of pages11
JournalOphthalmology
Volume91
Issue number4
StatePublished - Jan 1 1984

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Filtering Surgery
Fluorouracil
Glaucoma
Intraocular Pressure
Neovascular Glaucoma
Wounds and Injuries
Visual Acuity
Needles

ASJC Scopus subject areas

  • Ophthalmology

Cite this

5-Fluorouracil and glaucoma filtering surgery. II. A pilot study. / Heuer, D. K.; Parrish, Richard K; Palmberg, Paul.

In: Ophthalmology, Vol. 91, No. 4, 01.01.1984, p. 384-394.

Research output: Contribution to journalArticle

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