5-Fluorouracil and Glaucoma Filtering Surgery: II. A Pilot Study

Dale K. Heuer, Richard K. Parrish, Michael G. Gressel, Elizabeth Hodapp, Paul F. Palmberg, Douglas R. Anderson

Research output: Contribution to journalArticle

276 Scopus citations

Abstract

5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses. Twenty-seven (79%) of the 34 aphakic eyes with glaucoma achieved an intraocular pressure (IOP) of ≤21 mmHg (range of follow-up on nonreoperated eyes, 91-468 days). Nine (69%) of 13 eyes with neovascular glaucoma achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 120-379 days). Eight (89%) of nine phakic eyes with glaucoma following unsuccessful filtering procedures achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 134-394 days). Visual acuities remained within one line of their preoperative levels or improved in 32 (94%) of the 34 aphakic eyes with glaucoma, eight (62%) of the 13 eyes with neovascular glaucoma, and six (67%) of the nine phakic eyes with glaucoma following unsuccessful filtering procedures. Postoperative corneal epithelial defects occurred in 45% of the cases. Conjunctival wound and conjunctival needle tract leaks were observed in 41% of the cases, but only one eye required wound revision. No other serious side effects that we attributed to 5-FU were observed. It seems that postoperative subconjunctival 5-FU increases the likelihood of achieving IOP control following filtering surgery in eyes with poor surgical prognoses; however, a randomized clinical trial is necessary to confirm this.

Original languageEnglish (US)
Pages (from-to)384-394
Number of pages11
JournalOphthalmology
Volume91
Issue number4
DOIs
StatePublished - 1984

Keywords

  • 5-fluorouracil
  • filtering surgery
  • glaucoma following unsuccessful filtering surgery
  • glaucoma in aphakia
  • glaucoma surgery
  • neovascular glaucoma

ASJC Scopus subject areas

  • Ophthalmology

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