Abstract
5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses. Twenty-seven (79%) of the 34 aphakic eyes with glaucoma achieved an intraocular pressure (IOP) of ≤21 mmHg (range of follow-up on nonreoperated eyes, 91-468 days). Nine (69%) of 13 eyes with neovascular glaucoma achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 120-379 days). Eight (89%) of nine phakic eyes with glaucoma following unsuccessful filtering procedures achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 134-394 days). Visual acuities remained within one line of their preoperative levels or improved in 32 (94%) of the 34 aphakic eyes with glaucoma, eight (62%) of the 13 eyes with neovascular glaucoma, and six (67%) of the nine phakic eyes with glaucoma following unsuccessful filtering procedures. Postoperative corneal epithelial defects occurred in 45% of the cases. Conjunctival wound and conjunctival needle tract leaks were observed in 41% of the cases, but only one eye required wound revision. No other serious side effects that we attributed to 5-FU were observed. It seems that postoperative subconjunctival 5-FU increases the likelihood of achieving IOP control following filtering surgery in eyes with poor surgical prognoses; however, a randomized clinical trial is necessary to confirm this.
| Original language | English |
|---|---|
| Pages (from-to) | 384-394 |
| Number of pages | 11 |
| Journal | Ophthalmology |
| Volume | 91 |
| Issue number | 4 |
| State | Published - Jan 1 1984 |
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ASJC Scopus subject areas
- Ophthalmology
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5-Fluorouracil and glaucoma filtering surgery. II. A pilot study. / Heuer, D. K.; Parrish, Richard K; Palmberg, Paul.
In: Ophthalmology, Vol. 91, No. 4, 01.01.1984, p. 384-394.Research output: Contribution to journal › Article
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TY - JOUR
T1 - 5-Fluorouracil and glaucoma filtering surgery. II. A pilot study
AU - Heuer, D. K.
AU - Parrish, Richard K
AU - Palmberg, Paul
PY - 1984/1/1
Y1 - 1984/1/1
N2 - 5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses. Twenty-seven (79%) of the 34 aphakic eyes with glaucoma achieved an intraocular pressure (IOP) of ≤21 mmHg (range of follow-up on nonreoperated eyes, 91-468 days). Nine (69%) of 13 eyes with neovascular glaucoma achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 120-379 days). Eight (89%) of nine phakic eyes with glaucoma following unsuccessful filtering procedures achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 134-394 days). Visual acuities remained within one line of their preoperative levels or improved in 32 (94%) of the 34 aphakic eyes with glaucoma, eight (62%) of the 13 eyes with neovascular glaucoma, and six (67%) of the nine phakic eyes with glaucoma following unsuccessful filtering procedures. Postoperative corneal epithelial defects occurred in 45% of the cases. Conjunctival wound and conjunctival needle tract leaks were observed in 41% of the cases, but only one eye required wound revision. No other serious side effects that we attributed to 5-FU were observed. It seems that postoperative subconjunctival 5-FU increases the likelihood of achieving IOP control following filtering surgery in eyes with poor surgical prognoses; however, a randomized clinical trial is necessary to confirm this.
AB - 5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses. Twenty-seven (79%) of the 34 aphakic eyes with glaucoma achieved an intraocular pressure (IOP) of ≤21 mmHg (range of follow-up on nonreoperated eyes, 91-468 days). Nine (69%) of 13 eyes with neovascular glaucoma achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 120-379 days). Eight (89%) of nine phakic eyes with glaucoma following unsuccessful filtering procedures achieved an IOP of ≤21 mmHg (range of follow-up on nonreoperated eyes, 134-394 days). Visual acuities remained within one line of their preoperative levels or improved in 32 (94%) of the 34 aphakic eyes with glaucoma, eight (62%) of the 13 eyes with neovascular glaucoma, and six (67%) of the nine phakic eyes with glaucoma following unsuccessful filtering procedures. Postoperative corneal epithelial defects occurred in 45% of the cases. Conjunctival wound and conjunctival needle tract leaks were observed in 41% of the cases, but only one eye required wound revision. No other serious side effects that we attributed to 5-FU were observed. It seems that postoperative subconjunctival 5-FU increases the likelihood of achieving IOP control following filtering surgery in eyes with poor surgical prognoses; however, a randomized clinical trial is necessary to confirm this.
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M3 - Article
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AN - SCOPUS:0021260588
VL - 91
SP - 384
EP - 394
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 4
ER -