Abstract
Multivoxel 3D localized proton spectroscopy using a hybrid of 1D 8th- order transverse Hadamard spectroscopic imaging (HSI) with 2D chemical shift imaging (CSI) is demonstrated in human brain. The spatially selective HSI pulse incorporates naturally into the PRESS sequence (TE = 135 ms), which then both excites an 8 x 8 x 6 cm parallelepiped volume of interest (VOI) and subdivides it into eight slices. The planes of these slices are further partitioned into 16 x 16 voxel arrays using 2D CSI to yield 8 x 8 x 8 voxels within the VOI. Simultaneous 3D coverage yields good voxel signal-to-noise (8, 12, and 22 for choline, creatine, and N-acetylaspartate, respectively) from these 0.75-ml voxels, in ~45 min. The high spatial isolation allows localization to within less than 1 cm from the skull without fat contamination.
Original language | English (US) |
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Pages (from-to) | 34-40 |
Number of pages | 7 |
Journal | Magnetic Resonance in Medicine |
Volume | 39 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1998 |
Externally published | Yes |
Keywords
- Brain
- CSI
- Hadamard
- Localized spectroscopy
- Proton
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology