Abstract
Multivoxel 3D localized proton spectroscopy using a hybrid of 1D 8th- order transverse Hadamard spectroscopic imaging (HSI) with 2D chemical shift imaging (CSI) is demonstrated in human brain. The spatially selective HSI pulse incorporates naturally into the PRESS sequence (TE = 135 ms), which then both excites an 8 x 8 x 6 cm parallelepiped volume of interest (VOI) and subdivides it into eight slices. The planes of these slices are further partitioned into 16 x 16 voxel arrays using 2D CSI to yield 8 x 8 x 8 voxels within the VOI. Simultaneous 3D coverage yields good voxel signal-to-noise (8, 12, and 22 for choline, creatine, and N-acetylaspartate, respectively) from these 0.75-ml voxels, in ~45 min. The high spatial isolation allows localization to within less than 1 cm from the skull without fat contamination.
| Original language | English |
|---|---|
| Pages (from-to) | 34-40 |
| Number of pages | 7 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1998 |
| Externally published | Yes |
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Keywords
- Brain
- CSI
- Hadamard
- Localized spectroscopy
- Proton
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
3D multivoxel proton spectroscopy of human brain using a hybrid of 8th- order hadamard encoding with 2D chemical shift imaging. / Gonen, Oded; Murdoch, James B.; Stoyanova, Radka; Goelman, Gadi.
In: Magnetic Resonance in Medicine, Vol. 39, No. 1, 01.01.1998, p. 34-40.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 3D multivoxel proton spectroscopy of human brain using a hybrid of 8th- order hadamard encoding with 2D chemical shift imaging
AU - Gonen, Oded
AU - Murdoch, James B.
AU - Stoyanova, Radka
AU - Goelman, Gadi
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Multivoxel 3D localized proton spectroscopy using a hybrid of 1D 8th- order transverse Hadamard spectroscopic imaging (HSI) with 2D chemical shift imaging (CSI) is demonstrated in human brain. The spatially selective HSI pulse incorporates naturally into the PRESS sequence (TE = 135 ms), which then both excites an 8 x 8 x 6 cm parallelepiped volume of interest (VOI) and subdivides it into eight slices. The planes of these slices are further partitioned into 16 x 16 voxel arrays using 2D CSI to yield 8 x 8 x 8 voxels within the VOI. Simultaneous 3D coverage yields good voxel signal-to-noise (8, 12, and 22 for choline, creatine, and N-acetylaspartate, respectively) from these 0.75-ml voxels, in ~45 min. The high spatial isolation allows localization to within less than 1 cm from the skull without fat contamination.
AB - Multivoxel 3D localized proton spectroscopy using a hybrid of 1D 8th- order transverse Hadamard spectroscopic imaging (HSI) with 2D chemical shift imaging (CSI) is demonstrated in human brain. The spatially selective HSI pulse incorporates naturally into the PRESS sequence (TE = 135 ms), which then both excites an 8 x 8 x 6 cm parallelepiped volume of interest (VOI) and subdivides it into eight slices. The planes of these slices are further partitioned into 16 x 16 voxel arrays using 2D CSI to yield 8 x 8 x 8 voxels within the VOI. Simultaneous 3D coverage yields good voxel signal-to-noise (8, 12, and 22 for choline, creatine, and N-acetylaspartate, respectively) from these 0.75-ml voxels, in ~45 min. The high spatial isolation allows localization to within less than 1 cm from the skull without fat contamination.
KW - Brain
KW - CSI
KW - Hadamard
KW - Localized spectroscopy
KW - Proton
UR - http://www.scopus.com/inward/record.url?scp=0031964291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031964291&partnerID=8YFLogxK
U2 - 10.1002/mrm.1910390108
DO - 10.1002/mrm.1910390108
M3 - Article
C2 - 9438435
AN - SCOPUS:0031964291
VL - 39
SP - 34
EP - 40
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 1
ER -