25,26-Dihydroxycholecalciferol: A precursor in the renal synthesis of 25-hydroxycholecalciferol-26,23-lactone

Bruce W. Hollis, Bernard A. Roos, Phillip W. Lambert

Research output: Contribution to journalArticle

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Abstract

Both rachitic 1,25-dihydroxycholecalciferol-treated and normal chicks produced detectable quantities of 25-hydroxycholecalciferol-26,23-lactone, although renal homogenates from rachitic chicks failed to produce this compound. The addition of either 25-hydroxycholecalciferol or 25,26-dihydroxycholecalciferol to the renal homogenates led to the production of the lactone, although more lactone resulted when 25,26-dihydroxycholecalciferol was used. When tritiated 25-hydroxycholecalciferol was added to rachitic 1,25-dihydroxycholecalciferol-treated or normal chick renal homogenates, an unidentified tritiated vitamin D metabolite distinct from 25-hydroxycholecalciferol-26,23-lactone was produced.

Original languageEnglish (US)
Pages (from-to)520-528
Number of pages9
JournalTopics in Catalysis
Volume95
Issue number2
DOIs
StatePublished - Jan 1 1980

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Biophysics
  • Molecular Biology

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