25-Hydroxyvitamin D concentration, vitamin D intake and joint symptoms in postmenopausal women

Rowan T. Chlebowski, Karen C. Johnson, Dorothy Lane, Mary Pettinger, Charles L. Kooperberg, Jean Wactawski-Wende, Tom Rohan, Mary Jo O'Sullivan, Shagufta Yasmeen, Robert A. Hiatt, James M. Shikany, Mara Vitolins, Janu Khandekar, F. Allan Hubbell

Research output: Contribution to journalArticle

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Abstract

Introduction: Low 25-hydroxyvitamin D (25(OH) D) concentrations have been associated with radiologic worsening of osteoarthritis in some reports. However, the results are mixed and few studies have evaluated associations between 25(OH) D concentrations and both total vitamin D intake and clinical joint symptoms. Study design: Cross-sectional analyses of information from a subset of 1993 postmenopausal women obtained at baseline entry in the Women's Health Initiative Calcium plus Vitamin D clinical trial. Main Outcome Measures: 25(OH) D concentration, total vitamin D intake (diet plus supplements), presence and severity of joint pain and joint swelling. Results: The 25(OH) D levels were commonly low with 53% having deficient (<50 nmol/L) and only 17% having sufficient (>72 nmol/L) levels. Joint pain (reported by 74%) and joint swelling (reported by 34%) were also commonly reported. 25(OH) D concentrations were modestly correlated with total vitamin D intake (R = 0.29, p < 0.0001); however, considerable variability in 25(OH) D concentrations for a given vitamin D intake was seen. In adjusted linear regression models, lower serum 25(OH) D concentrations were associated with higher average joint pain score (P = 0.01 for trend) with differences most apparent in the lowest 25(OH) D levels sextile. Conclusions: Relatively low 25(OH) D levels and a high frequency of joint symptoms were common in this population of postmenopausal women. Total vitamin D intake was only modestly associated with 25(OH) D. Low serum 25(OH) D concentrations were associated with higher joint pain scores. These findings can inform the design of future intervention trials.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalMaturitas
Volume68
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Fingerprint

Vitamin D
Joints
Arthralgia
Swelling
Linear Models
Women's Health
Nutrition
Serum
Linear regression
Osteoarthritis
25-hydroxyvitamin D
Cross-Sectional Studies
Outcome Assessment (Health Care)
Clinical Trials
Diet
Calcium
Population

Keywords

  • 25-Hydroxyvitamin D
  • Joint pain
  • Vitamin D
  • Women's Health Initiative

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chlebowski, R. T., Johnson, K. C., Lane, D., Pettinger, M., Kooperberg, C. L., Wactawski-Wende, J., ... Hubbell, F. A. (2011). 25-Hydroxyvitamin D concentration, vitamin D intake and joint symptoms in postmenopausal women. Maturitas, 68(1), 73-78. https://doi.org/10.1016/j.maturitas.2010.10.006

25-Hydroxyvitamin D concentration, vitamin D intake and joint symptoms in postmenopausal women. / Chlebowski, Rowan T.; Johnson, Karen C.; Lane, Dorothy; Pettinger, Mary; Kooperberg, Charles L.; Wactawski-Wende, Jean; Rohan, Tom; O'Sullivan, Mary Jo; Yasmeen, Shagufta; Hiatt, Robert A.; Shikany, James M.; Vitolins, Mara; Khandekar, Janu; Hubbell, F. Allan.

In: Maturitas, Vol. 68, No. 1, 01.01.2011, p. 73-78.

Research output: Contribution to journalArticle

Chlebowski, RT, Johnson, KC, Lane, D, Pettinger, M, Kooperberg, CL, Wactawski-Wende, J, Rohan, T, O'Sullivan, MJ, Yasmeen, S, Hiatt, RA, Shikany, JM, Vitolins, M, Khandekar, J & Hubbell, FA 2011, '25-Hydroxyvitamin D concentration, vitamin D intake and joint symptoms in postmenopausal women', Maturitas, vol. 68, no. 1, pp. 73-78. https://doi.org/10.1016/j.maturitas.2010.10.006
Chlebowski RT, Johnson KC, Lane D, Pettinger M, Kooperberg CL, Wactawski-Wende J et al. 25-Hydroxyvitamin D concentration, vitamin D intake and joint symptoms in postmenopausal women. Maturitas. 2011 Jan 1;68(1):73-78. https://doi.org/10.1016/j.maturitas.2010.10.006
Chlebowski, Rowan T. ; Johnson, Karen C. ; Lane, Dorothy ; Pettinger, Mary ; Kooperberg, Charles L. ; Wactawski-Wende, Jean ; Rohan, Tom ; O'Sullivan, Mary Jo ; Yasmeen, Shagufta ; Hiatt, Robert A. ; Shikany, James M. ; Vitolins, Mara ; Khandekar, Janu ; Hubbell, F. Allan. / 25-Hydroxyvitamin D concentration, vitamin D intake and joint symptoms in postmenopausal women. In: Maturitas. 2011 ; Vol. 68, No. 1. pp. 73-78.
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