2,4,6-Octatrienoic acid is a novel promoter of melanogenesis and antioxidant defence in normal human melanocytes via PPAR-γ activation

Enrica Flori, Arianna Mastrofrancesco, Daniela Kovacs, Yuval Ramot, Stefania Briganti, Barbara Bellei, Ralf Paus, Mauro Picardo

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Given the importance of the tanning response in protecting human skin from the harmful effects of UV radiation, one important research priority is to identify novel molecules that are capable of promoting pigmentation and/or antioxidant defence. Parrodienes share some structural features with carotenoids and retinoids, stimulate cell antioxidant defence and counteract senescence-like phenotype in fibroblasts. We selected the parrodiene-derivative 2,4,6-octatrienoic acid (Octa) to study its impact on key parameters of melanogenesis and antioxidant defence in organ-cultured human skin and in normal human melanocytes. Octa promoted melanogenesis by up-regulating tyrosinase and microphthalmia-associated transcription factor expression. This correlated with an increase of melanin content in both human epidermis in situ and cultured human epidermal melanocytes. Moreover, Octa increased the biological antioxidant potential content and the expression and activity of catalase. Activation of peroxisome proliferator-activated receptor (PPAR)-γ was necessary to evoke these effects. These data strongly encourage the systematic study of Octa as a novel candidate promoter of human skin photoprotection.

Original languageEnglish (US)
Pages (from-to)618-630
Number of pages13
JournalPigment Cell and Melanoma Research
Volume24
Issue number4
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • Catalase
  • MITF
  • Melanogenesis
  • PPAR-γ
  • Tyrosinase

ASJC Scopus subject areas

  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology

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