2001 consensus guidelines for the management of women with cervical cytological abnormalities

Thomas C. Wright, J. Thomas Cox, L. Stewart Massad, Leo B. Twiggs, Edward J. Wilkinson

Research output: Contribution to journalArticle

1039 Citations (Scopus)

Abstract

Objective To provide evidence-based consensus guidelines for the management of women with cervical cytological abnormalities and cervical cancer precursors. Participants A panel of 121 experts in the diagnosis and management of cervical cancer precursors, including representatives from 29 professional organizations, federal agencies, and national and international health organizations, were invited to participate in a consensus conference sponsored by the American Society for Colposcopy and Cervical Pathology (ASCCP). Evidence and Consensus Process Guidelines for the management of women with cervical cytological abnormalities were developed through a multistep process. Starting 6 months before the conference, working groups developed draft management guidelines based on formal literature reviews of English-language articles published in 1988-2001, as well as input from the professional community at large, obtained using interactive Internet-based bulletin boards. On September 6-8, 2001, the ASCCP Consensus Conference was held in Bethesda, Md. Guidelines with supporting evidence were presented and underwent discussion, revision, and voting. Conclusions Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASCUS) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (ASC-H). Women with ASC-US should be managed using a program of 2 repeat cytology tests, immediate colposcopy, or DNA testing for high-risk types of human papillomavirus (HPV). Testing for HPV DNA is the preferred approach when liquid-based cytology is used for screening. In most instances, women with ASC-H, low-grade squamous intraepithelial lesion, HSIL, and atypical glandular cells should be referred for immediate colposcopic evaluation.

Original languageEnglish
Pages (from-to)2120-2129
Number of pages10
JournalJournal of the American Medical Association
Volume287
Issue number16
StatePublished - Apr 24 2002
Externally publishedYes

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Consensus
Colposcopy
Guidelines
Uterine Cervical Neoplasms
Cell Biology
Pathology
International Agencies
Papanicolaou Test
DNA
Politics
Internet
Language
Atypical Squamous Cells of the Cervix
Organizations
Health
Squamous Intraepithelial Lesions of the Cervix

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wright, T. C., Thomas Cox, J., Stewart Massad, L., Twiggs, L. B., & Wilkinson, E. J. (2002). 2001 consensus guidelines for the management of women with cervical cytological abnormalities. Journal of the American Medical Association, 287(16), 2120-2129.

2001 consensus guidelines for the management of women with cervical cytological abnormalities. / Wright, Thomas C.; Thomas Cox, J.; Stewart Massad, L.; Twiggs, Leo B.; Wilkinson, Edward J.

In: Journal of the American Medical Association, Vol. 287, No. 16, 24.04.2002, p. 2120-2129.

Research output: Contribution to journalArticle

Wright, TC, Thomas Cox, J, Stewart Massad, L, Twiggs, LB & Wilkinson, EJ 2002, '2001 consensus guidelines for the management of women with cervical cytological abnormalities', Journal of the American Medical Association, vol. 287, no. 16, pp. 2120-2129.
Wright TC, Thomas Cox J, Stewart Massad L, Twiggs LB, Wilkinson EJ. 2001 consensus guidelines for the management of women with cervical cytological abnormalities. Journal of the American Medical Association. 2002 Apr 24;287(16):2120-2129.
Wright, Thomas C. ; Thomas Cox, J. ; Stewart Massad, L. ; Twiggs, Leo B. ; Wilkinson, Edward J. / 2001 consensus guidelines for the management of women with cervical cytological abnormalities. In: Journal of the American Medical Association. 2002 ; Vol. 287, No. 16. pp. 2120-2129.
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