2-Deoxy-d-glucose exploits increased glucose metabolism in cancer and viral-infected cells: Relevance to its use in India against SARS-CoV-2

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1 Scopus citations

Abstract

Mechanisms discovered to drive increased glucose metabolism in cancer cells are found to be similar to those in viral-infected cells. In this mini review, we summarize the major pathways by which the sugar analog, 2-Deoxy-d-glucose, has been shown to exploit increased glucose metabolism in cancer and how this information applies to viral-infected cells. Moreover, we highlight the relevance of these findings to the emergency approval of 2-Deoxy-d-glucose in India to be used against SARS-CoV-2, the virus responsible for COVID-19.

Original languageEnglish (US)
Pages (from-to)1198-1204
Number of pages7
JournalIUBMB life
Volume73
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • 2-deoxy-d-glucose or 2-DG
  • cancer
  • cellular glucose metabolism
  • ER stress
  • glycolysis
  • SARS-CoV-2
  • viruses

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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