2-Chlorodeoxyadenosine to Treat Refractory Histiocytosis X

Alan Saven, Michael L. Figueroa, Lawrence D. Piro, Joseph D. Rosenblatt

Research output: Contribution to journalLetterpeer-review

48 Scopus citations


To the Editor: Treatment of histiocytosis X is palliative at best. It includes corticosteroids, alkylating agents, antimetabolites, vinca alkaloids, and irradiation1. Since 2-chlorodeoxyadenosine, a purine substrate analogue active against lymphoid cancers,2 is toxic to monocytes in vitro,3 and since tissue histiocytes are derived from circulating monocytes as they move from the intravascular space to soft tissues, we administered 2-chlorodeoxyadenosine to a patient with histiocytosis X. A 33-year-old woman had presented at the age of 15 years with polyuria and polydipsia due to diabetes insipidus. Two years later vesiculopustular lesions developed on her gingiva, scalp, and vagina that were histologically…

Original languageEnglish (US)
Pages (from-to)734-735
Number of pages2
JournalNew England Journal of Medicine
Issue number10
StatePublished - Sep 2 1993
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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