1, 2-Bis(diphenylphosphino)-1-phenylethane: A Chiral Ditertiary Phosphine Derived from Mandelic Acid Used as a Ligand in Asymmetric Homogeneous Hydrogenation Catalysts

R. B. King, J. Bakos, C. D. Hoff, L. Markó

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

During the last few years rhodium(I) complexes of chiral phosphines have been shown to be effective catalysts for the asymmetric hydrogenation of prochiral olefins.1-2-3 The optical yields in such reactions have been shown to be particularly high when chiral ditertiary phosphines are used which form rigid five-membered chelate rings. Examples of such chiral ditertiary phosphines include the ligand (—)-(o-CH3OC6H4)-(CeH5)PCH2CH2P(CH2C6H4OCH3-o) of Knowles et al.4 and the ligands (-)-(2S, 3S)-(C6H5)2PCH(CH3)CH(CH3)-P(C6H5)2 (“(S.S)-chiraphos”)5 and (C6H5)2PCH(CH3)-CH2P(C6H5)2 (“R-prophos”)6 of Fryzuk and Bosnich.

Original languageEnglish (US)
Pages (from-to)1729-1731
Number of pages3
JournalJournal of Organic Chemistry
Volume44
Issue number10
DOIs
StatePublished - Feb 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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