Abstract
The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-283 |
| Number of pages | 3 |
| Journal | Molecular Brain Research |
| Volume | 56 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - May 1 1998 |
| Externally published | Yes |
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Keywords
- μ-Opioid receptor
- Gastrointestinal motility
- Knockout
- Morphine
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
Cite this
μ-Opioid receptor-knockout mice : The role of μ-opioid receptor in gastrointestinal transit. / Roy, Sabita; Liu, Hsien Ching; Loh, Horace H.
In: Molecular Brain Research, Vol. 56, No. 1-2, 01.05.1998, p. 281-283.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - μ-Opioid receptor-knockout mice
T2 - The role of μ-opioid receptor in gastrointestinal transit
AU - Roy, Sabita
AU - Liu, Hsien Ching
AU - Loh, Horace H.
PY - 1998/5/1
Y1 - 1998/5/1
N2 - The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.
AB - The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.
KW - μ-Opioid receptor
KW - Gastrointestinal motility
KW - Knockout
KW - Morphine
UR - http://www.scopus.com/inward/record.url?scp=0032078392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032078392&partnerID=8YFLogxK
U2 - 10.1016/S0169-328X(98)00051-5
DO - 10.1016/S0169-328X(98)00051-5
M3 - Article
C2 - 9602153
AN - SCOPUS:0032078392
VL - 56
SP - 281
EP - 283
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -