Abstract
The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-283 |
| Number of pages | 3 |
| Journal | Molecular Brain Research |
| Volume | 56 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - May 1 1998 |
| Externally published | Yes |
Keywords
- Gastrointestinal motility
- Knockout
- Morphine
- μ-Opioid receptor
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
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Cite this
Roy, S., Liu, H. C., & Loh, H. H. (1998). μ-Opioid receptor-knockout mice: The role of μ-opioid receptor in gastrointestinal transit. Molecular Brain Research, 56(1-2), 281-283. https://doi.org/10.1016/S0169-328X(98)00051-5