μ-Opioid receptor-knockout mice: The role of μ-opioid receptor in gastrointestinal transit

Sabita Roy, Hsien Ching Liu, Horace H. Loh

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.

Original languageEnglish (US)
Pages (from-to)281-283
Number of pages3
JournalMolecular Brain Research
Volume56
Issue number1-2
DOIs
StatePublished - May 1 1998
Externally publishedYes

Fingerprint

Gastrointestinal Transit
Opioid Receptors
Knockout Mice
Wild Animals
Morphine

Keywords

  • μ-Opioid receptor
  • Gastrointestinal motility
  • Knockout
  • Morphine

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

μ-Opioid receptor-knockout mice : The role of μ-opioid receptor in gastrointestinal transit. / Roy, Sabita; Liu, Hsien Ching; Loh, Horace H.

In: Molecular Brain Research, Vol. 56, No. 1-2, 01.05.1998, p. 281-283.

Research output: Contribution to journalArticle

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