μ-Opioid receptor-knockout mice: The role of μ-opioid receptor in gastrointestinal transit

Sabita Roy; Hsien Ching Liu; Horace H. Loh

doi:10.1016/S0169-328X(98)00051-5

μ-Opioid receptor-knockout mice: The role of μ-opioid receptor in gastrointestinal transit

Sabita Roy, Hsien Ching Liu, Horace H. Loh

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.

Original language	English (US)
Pages (from-to)	281-283
Number of pages	3
Journal	Molecular Brain Research
Volume	56
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(98)00051-5
State	Published - May 1998
Externally published	Yes

Keywords

Gastrointestinal motility
Knockout
Morphine
μ-Opioid receptor

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(98)00051-5

Cite this

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title = "μ-Opioid receptor-knockout mice: The role of μ-opioid receptor in gastrointestinal transit",

abstract = "The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.",

keywords = "Gastrointestinal motility, Knockout, Morphine, μ-Opioid receptor",

author = "Sabita Roy and Liu, {Hsien Ching} and Loh, {Horace H.}",

note = "Funding Information: This work was supported by NIH grants DA00564, DA01583, DA05695, K05-DA70554, F. and A. Stark Fund (MMF)-HHL and DA08188 (SR). ",

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AU - Liu, Hsien Ching

AU - Loh, Horace H.

N1 - Funding Information: This work was supported by NIH grants DA00564, DA01583, DA05695, K05-DA70554, F. and A. Stark Fund (MMF)-HHL and DA08188 (SR).

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AB - The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.

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μ-Opioid receptor-knockout mice: The role of μ-opioid receptor in gastrointestinal transit

Abstract

Keywords

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