β-cell Cav channel regulation in physiology and pathophysiology

Shao Nian Yang, Per Olof Berggren

Research output: Contribution to journalShort survey

87 Scopus citations

Abstract

The β-cell is equipped with at least six voltage-gated Ca2+ (Cav) channel α1-subunits designated Ca v1.2, Cav1.3, Cav2.1, Cav2.2, Cav2.3, and Cav3.1. These principal subunits, together with certain auxiliary subunits, assemble into different types of Cav channels conducting L-, P/Q-, N-, R-, and T-type Ca2+ currents, respectively. The β-cell shares customary mechanisms of Cav channel regulation with other excitable cells, such as protein phosphorylation, Ca2+-dependent inactivation, and G protein modulation. However, the β-cell displays some characteristic features to bring these mechanisms into play. In islet β-cells, Cav channels can be highly phosphorylated under basal conditions and thus marginally respond to further phosphorylation. In β-cell lines, Cav channels can be surrounded by tonically activated protein phosphatases dominating over protein kinases; thus their activity is dramatically enhanced by inhibition of protein phosphatases. During the last 10 years, we have revealed some novel mechanisms of β-cell Cav channel regulation under physiological and pathophysiological conditions, including the involvement of exocytotic proteins, inositol hexakisphosphate, and type 1 diabetic serum. This minireview highlights characteristic features of customary mechanisms of Cav channel regulation in β-cells and also reviews our studies on newly identified mechanisms of β-cell Cav channel regulation.

Original languageEnglish (US)
Pages (from-to)E16-E28
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume288
Issue number1 51-1
DOIs
StatePublished - Jan 1 2005

Keywords

  • Exocytotic proteins
  • Inositol hexakisphosphate
  • Pancreatic β-cell
  • Type 1 diabetic serum
  • Voltage-gated Ca channels

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Fingerprint Dive into the research topics of 'β-cell Ca<sub>v</sub> channel regulation in physiology and pathophysiology'. Together they form a unique fingerprint.

  • Cite this