β-Adrenergic receptor subtypes in stress-induced behavioral depression

Subhash C. Pandey, Xinguo Ren, Jacqeuline Sagen, Ghanshyam N. Pandey

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The purpose of this study was to examine the role of β-adrenergic receptors in an animal model of stress-induced behavioral depression. β-Adrenergic receptors in several brain regions and leukocytes of rats were determined by receptor binding techniques using 125I-cyanopindolol (cyp) as ligand and propranolol as displacer for total β-adrenergic receptors, and ICI 86,406 for β1- and ICI 118, 551 for β2-adrenergic receptors. We observed that the maximum number of binding sites (Bmax) and the apparent dissociation constant (Kd) of 125I-cyp binding to total β-adrenergic receptors were increased in hippocampus of stressed rats with escape deficits (48 h after training) as compared to control rats. This increase was due to an increase in Bmax and Kd of 125I-cyp binding to β1-adrenergic receptors but not to β2-adrenergic receptors. There was no significant difference in β1-adrenergic receptors in cortex and cerebellum or β2-adrenergic receptors in hippocampus, cortex, cerebellum, or leukocytes of stressed (48 h after training) rats with escape deficits as compared to control rats. Interestingly, it was observed that β1- and β1-adrenergic receptors in various brain regions (cortex, cerebellum, and hippocampus) and β2-adrenergic receptors in leukocytes of stressed rats (10 days after training) were not significantly different from control rats, although escape deficits were still present. These results suggest that abnormalities in adrenergic neurotransmission are associated with an upregulation of β1-adrenergic receptors, which in turn may be involved in the early stages of behavioral deficits caused by uncontrollable shock.

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume51
Issue number2-3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Behavioral depression
  • Depression
  • Escape-deficit
  • Leukocytes
  • Rat brain
  • β-Adrenergic receptor subtypes

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Pharmacology
  • Toxicology

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