Abstract
We observed an induction of basic fibroblast growth factor (bFGF) mRNA in the rat retina after systemic administration of the α2-adrenergic agonists xylazine and clonidine. A single injection of xylazine or clonidine transiently increased bFGF mRNA. Preinjection of yohimbine, an α2- adrenergic antagonist, completely inhibited this increase. Higher dosage of yohimbine inhibited the baseline expression of bFGF. Of particular interest is the finding that the induced bFGF expression occurred almost exclusively in the inner segment region of photoreceptors. No increase in bFGF mRNA was found in the brain after either xylazine or clonidine injection. Xylazine or clonidine given systemically before and during constant light exposure also reduces photoreceptor degeneration in albino rats. These results indicate that regulation of bFGF expression in photoreceptors is unique in the CNS and suggest that endogenous bFGF promotes photoreceptor survival.
| Original language | English |
|---|---|
| Pages (from-to) | 5986-5992 |
| Number of pages | 7 |
| Journal | Journal of Neuroscience |
| Volume | 16 |
| Issue number | 19 |
| State | Published - Oct 1 1996 |
| Externally published | Yes |
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Keywords
- α-adrenergic receptors
- bFGF
- brain
- clonidine
- degeneration
- photoreceptors
- ra t
- retina
- xylazine
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
α2-Adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage. / Wen, Rong; Cheng, Tong; Li, Yiwen; Cao, Wei; Steinberg, Roy H.
In: Journal of Neuroscience, Vol. 16, No. 19, 01.10.1996, p. 5986-5992.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - α2-Adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage
AU - Wen, Rong
AU - Cheng, Tong
AU - Li, Yiwen
AU - Cao, Wei
AU - Steinberg, Roy H.
PY - 1996/10/1
Y1 - 1996/10/1
N2 - We observed an induction of basic fibroblast growth factor (bFGF) mRNA in the rat retina after systemic administration of the α2-adrenergic agonists xylazine and clonidine. A single injection of xylazine or clonidine transiently increased bFGF mRNA. Preinjection of yohimbine, an α2- adrenergic antagonist, completely inhibited this increase. Higher dosage of yohimbine inhibited the baseline expression of bFGF. Of particular interest is the finding that the induced bFGF expression occurred almost exclusively in the inner segment region of photoreceptors. No increase in bFGF mRNA was found in the brain after either xylazine or clonidine injection. Xylazine or clonidine given systemically before and during constant light exposure also reduces photoreceptor degeneration in albino rats. These results indicate that regulation of bFGF expression in photoreceptors is unique in the CNS and suggest that endogenous bFGF promotes photoreceptor survival.
AB - We observed an induction of basic fibroblast growth factor (bFGF) mRNA in the rat retina after systemic administration of the α2-adrenergic agonists xylazine and clonidine. A single injection of xylazine or clonidine transiently increased bFGF mRNA. Preinjection of yohimbine, an α2- adrenergic antagonist, completely inhibited this increase. Higher dosage of yohimbine inhibited the baseline expression of bFGF. Of particular interest is the finding that the induced bFGF expression occurred almost exclusively in the inner segment region of photoreceptors. No increase in bFGF mRNA was found in the brain after either xylazine or clonidine injection. Xylazine or clonidine given systemically before and during constant light exposure also reduces photoreceptor degeneration in albino rats. These results indicate that regulation of bFGF expression in photoreceptors is unique in the CNS and suggest that endogenous bFGF promotes photoreceptor survival.
KW - α-adrenergic receptors
KW - bFGF
KW - brain
KW - clonidine
KW - degeneration
KW - photoreceptors
KW - ra t
KW - retina
KW - xylazine
UR - http://www.scopus.com/inward/record.url?scp=0029788373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029788373&partnerID=8YFLogxK
M3 - Article
VL - 16
SP - 5986
EP - 5992
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 19
ER -