α2-Adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage

Rong Wen, Tong Cheng, Yiwen Li, Wei Cao, Roy H. Steinberg

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

We observed an induction of basic fibroblast growth factor (bFGF) mRNA in the rat retina after systemic administration of the α2-adrenergic agonists xylazine and clonidine. A single injection of xylazine or clonidine transiently increased bFGF mRNA. Preinjection of yohimbine, an α2- adrenergic antagonist, completely inhibited this increase. Higher dosage of yohimbine inhibited the baseline expression of bFGF. Of particular interest is the finding that the induced bFGF expression occurred almost exclusively in the inner segment region of photoreceptors. No increase in bFGF mRNA was found in the brain after either xylazine or clonidine injection. Xylazine or clonidine given systemically before and during constant light exposure also reduces photoreceptor degeneration in albino rats. These results indicate that regulation of bFGF expression in photoreceptors is unique in the CNS and suggest that endogenous bFGF promotes photoreceptor survival.

Original languageEnglish
Pages (from-to)5986-5992
Number of pages7
JournalJournal of Neuroscience
Volume16
Issue number19
StatePublished - Oct 1 1996
Externally publishedYes

Fingerprint

Adrenergic Agonists
Fibroblast Growth Factor 2
Xylazine
Light
Clonidine
Yohimbine
Messenger RNA
Injections
Adrenergic Antagonists
Retina
Brain

Keywords

  • α-adrenergic receptors
  • bFGF
  • brain
  • clonidine
  • degeneration
  • photoreceptors
  • ra t
  • retina
  • xylazine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

α2-Adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage. / Wen, Rong; Cheng, Tong; Li, Yiwen; Cao, Wei; Steinberg, Roy H.

In: Journal of Neuroscience, Vol. 16, No. 19, 01.10.1996, p. 5986-5992.

Research output: Contribution to journalArticle

@article{15386e2153db4c7ea0fa64786e45c683,
title = "α2-Adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage",
abstract = "We observed an induction of basic fibroblast growth factor (bFGF) mRNA in the rat retina after systemic administration of the α2-adrenergic agonists xylazine and clonidine. A single injection of xylazine or clonidine transiently increased bFGF mRNA. Preinjection of yohimbine, an α2- adrenergic antagonist, completely inhibited this increase. Higher dosage of yohimbine inhibited the baseline expression of bFGF. Of particular interest is the finding that the induced bFGF expression occurred almost exclusively in the inner segment region of photoreceptors. No increase in bFGF mRNA was found in the brain after either xylazine or clonidine injection. Xylazine or clonidine given systemically before and during constant light exposure also reduces photoreceptor degeneration in albino rats. These results indicate that regulation of bFGF expression in photoreceptors is unique in the CNS and suggest that endogenous bFGF promotes photoreceptor survival.",
keywords = "α-adrenergic receptors, bFGF, brain, clonidine, degeneration, photoreceptors, ra t, retina, xylazine",
author = "Rong Wen and Tong Cheng and Yiwen Li and Wei Cao and Steinberg, {Roy H.}",
year = "1996",
month = "10",
day = "1",
language = "English",
volume = "16",
pages = "5986--5992",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "19",

}

TY - JOUR

T1 - α2-Adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage

AU - Wen, Rong

AU - Cheng, Tong

AU - Li, Yiwen

AU - Cao, Wei

AU - Steinberg, Roy H.

PY - 1996/10/1

Y1 - 1996/10/1

N2 - We observed an induction of basic fibroblast growth factor (bFGF) mRNA in the rat retina after systemic administration of the α2-adrenergic agonists xylazine and clonidine. A single injection of xylazine or clonidine transiently increased bFGF mRNA. Preinjection of yohimbine, an α2- adrenergic antagonist, completely inhibited this increase. Higher dosage of yohimbine inhibited the baseline expression of bFGF. Of particular interest is the finding that the induced bFGF expression occurred almost exclusively in the inner segment region of photoreceptors. No increase in bFGF mRNA was found in the brain after either xylazine or clonidine injection. Xylazine or clonidine given systemically before and during constant light exposure also reduces photoreceptor degeneration in albino rats. These results indicate that regulation of bFGF expression in photoreceptors is unique in the CNS and suggest that endogenous bFGF promotes photoreceptor survival.

AB - We observed an induction of basic fibroblast growth factor (bFGF) mRNA in the rat retina after systemic administration of the α2-adrenergic agonists xylazine and clonidine. A single injection of xylazine or clonidine transiently increased bFGF mRNA. Preinjection of yohimbine, an α2- adrenergic antagonist, completely inhibited this increase. Higher dosage of yohimbine inhibited the baseline expression of bFGF. Of particular interest is the finding that the induced bFGF expression occurred almost exclusively in the inner segment region of photoreceptors. No increase in bFGF mRNA was found in the brain after either xylazine or clonidine injection. Xylazine or clonidine given systemically before and during constant light exposure also reduces photoreceptor degeneration in albino rats. These results indicate that regulation of bFGF expression in photoreceptors is unique in the CNS and suggest that endogenous bFGF promotes photoreceptor survival.

KW - α-adrenergic receptors

KW - bFGF

KW - brain

KW - clonidine

KW - degeneration

KW - photoreceptors

KW - ra t

KW - retina

KW - xylazine

UR - http://www.scopus.com/inward/record.url?scp=0029788373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029788373&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 5986

EP - 5992

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 19

ER -