α-Tocopherol and ubiquinones in rat brain subjected to decapitation ischemia

Kouichi Abe, Shinichi Yoshida, Brant D. Watson, Raul Busto, Kyuya Kogure, Myron D. Ginsberg

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Levels of α-tocopherol (α-Toc), reduced ubiquinones (QH2) and oxidized ubiquinones (Q) were assayed in rat forebrain subjected to decapitation ischemia. Post-decapitation levels of α-Toc decreased by 16% at 3 min and 20% at 15 min. Increases in Q9H2 (83%) and in Q10H2 (107%) were observed immediately following decapitation; thereafter their levels began to decrease and approached to the pre-ischemic values at 15 min. In contrast, Q9 and Q10 tended to increase continuously during ischemia. The data indicate that complete ischemia results in distinct changes in the recebral content of lipid-soluble antioxidants. The decrease of α-Toc may make the brain prone to peroxidative attack when cerebral tissue is subsequently reoxygenated.

Original languageEnglish (US)
Pages (from-to)166-169
Number of pages4
JournalBrain Research
Volume273
Issue number1
DOIs
StatePublished - Aug 22 1983

Keywords

  • cerebral ischemia
  • free radicals
  • oxidized ubiquinone
  • rat brain
  • reduced ubiquinone
  • α-tocopherol

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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