α-Synuclein in α-helical conformation at air-water interface: Implication of conformation and orientation changes during its accumulation/aggregation

Chengshan Wang; Nilam Shah; Garima Thakur; Feimeng Zhou; Roger M. Leblanc

doi:10.1039/c0cc02098b

α-Synuclein in α-helical conformation at air-water interface: Implication of conformation and orientation changes during its accumulation/aggregation

Chengshan Wang, Nilam Shah, Garima Thakur, Feimeng Zhou, Roger M. Leblanc

Chemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.

Original language	English (US)
Pages (from-to)	6702-6704
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	36
DOIs	https://doi.org/10.1039/c0cc02098b
State	Published - Sep 28 2010

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c0cc02098b

Fingerprint Dive into the research topics of 'α-Synuclein in α-helical conformation at air-water interface: Implication of conformation and orientation changes during its accumulation/aggregation'. Together they form a unique fingerprint.

Cite this

α-Synuclein in α-helical conformation at air-water interface : Implication of conformation and orientation changes during its accumulation/aggregation. / Wang, Chengshan; Shah, Nilam; Thakur, Garima; Zhou, Feimeng; Leblanc, Roger M.

In: Chemical Communications, Vol. 46, No. 36, 28.09.2010, p. 6702-6704.

Research output: Contribution to journal › Article › peer-review

@article{d196653bb87f4421afd0a14764eb0c85,

title = "α-Synuclein in α-helical conformation at air-water interface: Implication of conformation and orientation changes during its accumulation/aggregation",

abstract = "α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.",

author = "Chengshan Wang and Nilam Shah and Garima Thakur and Feimeng Zhou and Leblanc, {Roger M.}",

year = "2010",

month = sep,

day = "28",

doi = "10.1039/c0cc02098b",

language = "English (US)",

volume = "46",

pages = "6702--6704",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "36",

}

TY - JOUR

T1 - α-Synuclein in α-helical conformation at air-water interface

T2 - Implication of conformation and orientation changes during its accumulation/aggregation

AU - Wang, Chengshan

AU - Shah, Nilam

AU - Thakur, Garima

AU - Zhou, Feimeng

AU - Leblanc, Roger M.

PY - 2010/9/28

Y1 - 2010/9/28

N2 - α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.

AB - α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.

UR - http://www.scopus.com/inward/record.url?scp=77956320641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956320641&partnerID=8YFLogxK

U2 - 10.1039/c0cc02098b

DO - 10.1039/c0cc02098b

M3 - Article

C2 - 20714568

AN - SCOPUS:77956320641

VL - 46

SP - 6702

EP - 6704

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 36

ER -

α-Synuclein in α-helical conformation at air-water interface: Implication of conformation and orientation changes during its accumulation/aggregation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this