Abstract
α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6702-6704 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 46 |
| Issue number | 36 |
| DOIs | |
| State | Published - Sep 28 2010 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Cite this
Wang, C., Shah, N., Thakur, G., Zhou, F., & Leblanc, R. M. (2010). α-Synuclein in α-helical conformation at air-water interface: Implication of conformation and orientation changes during its accumulation/aggregation. Chemical Communications, 46(36), 6702-6704. https://doi.org/10.1039/c0cc02098b