α-Synuclein in α-helical conformation at air-water interface: Implication of conformation and orientation changes during its accumulation/aggregation

Chengshan Wang, Nilam Shah, Garima Thakur, Feimeng Zhou, Roger M. Leblanc

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.

Original languageEnglish (US)
Pages (from-to)6702-6704
Number of pages3
JournalChemical Communications
Volume46
Issue number36
DOIs
StatePublished - Sep 28 2010

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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