Abstract
α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.
| Original language | English |
|---|---|
| Pages (from-to) | 6702-6704 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 46 |
| Issue number | 36 |
| DOIs | |
| State | Published - Sep 28 2010 |
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ASJC Scopus subject areas
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Catalysis
- Chemistry(all)
Cite this
α-Synuclein in α-helical conformation at air-water interface : Implication of conformation and orientation changes during its accumulation/aggregation. / Wang, Chengshan; Shah, Nilam; Thakur, Garima; Zhou, Feimeng; Leblanc, Roger.
In: Chemical Communications, Vol. 46, No. 36, 28.09.2010, p. 6702-6704.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - α-Synuclein in α-helical conformation at air-water interface
T2 - Implication of conformation and orientation changes during its accumulation/aggregation
AU - Wang, Chengshan
AU - Shah, Nilam
AU - Thakur, Garima
AU - Zhou, Feimeng
AU - Leblanc, Roger
PY - 2010/9/28
Y1 - 2010/9/28
N2 - α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.
AB - α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.
UR - http://www.scopus.com/inward/record.url?scp=77956320641&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956320641&partnerID=8YFLogxK
U2 - 10.1039/c0cc02098b
DO - 10.1039/c0cc02098b
M3 - Article
C2 - 20714568
AN - SCOPUS:77956320641
VL - 46
SP - 6702
EP - 6704
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 36
ER -