α-Melanocyte-stimulating hormone-Induced eruptive nevi

Adela R. Cardones, James M. Grichnik

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Background: Synthetic peptides that target proopiomelanocortin receptors are being investigated as a novel and safe way to tan. It has been postulated that synthetic a-melanocyte-stimulating hormone (α-MSH) peptides may have protective effects against the development of melanoma because of their melanogenic activity. Their ultimate biological effect, however, especially in patients with dysplastic nevi or previous melanoma, has yet to be determined. Observations: A 40-year-old white man with a history of melanoma and multiple dysplastic nevi selfadministered synthetic α-MSH. He developed crops of new pigmented nevi, many of which had atypical clinical and histopathologic features. The preexisting nevi became darker and acquired growth features. After α- MSH use was discontinued, the nevi progressively lightened and lost their growth features. Conclusions: Synthetic α-MSH peptides can drive proliferation of neoplastic melanocytic cells in predisposed patients. This could present an increased risk for melanoma development.

Original languageEnglish (US)
Pages (from-to)441-444
Number of pages4
JournalArchives of dermatology
Volume145
Issue number4
DOIs
StatePublished - Apr 1 2009

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ASJC Scopus subject areas

  • Dermatology

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