16 of 35 patients (46%) with malignant melanoma were found to have cytoplasmic œstrogen-receptor activity in biopsy specimens. Œtrogen-receptor activity was detected in primary lesions, lymph-node metastases, skin metastases, and visceral metastases. Equal percentages of males and females had positive assays. Scatchard analysis of binding in one case was consistent with a single class of high-affinity receptor sites.
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