Project: Research project

Project Details


Proton Magnetic Resonance Spectroscopic Imaging (MRSI) enables the
distribution of a number of MR-observable tissue metabolites to be
mapped, offering considerable clinical potential as a diagnostic imaging
technique. However, for brain studies, the spatial extent of the
available information has been limited by acquisition time constrains,
and the necessity to avoid signal contamination from subcutaneous lipid

The goal of this project is the measurement of 3D brain metabolite
distributions over a large volume that includes cortical surface
regions, and with high spatial resolution. This will be achieved by the
development of a 1H MRSI method that uses rapid acquisition combined
with a dual-density k-space sampling distribution, that simultaneously
provides high-sensitivity for metabolite distributions and high spatial
resolution for subcutaneous lipid regions. Post-processing methods will
be used to further diminish ringing and contamination from subcutaneous
lipid signals, and motion artifacts. High-resolution mapping for
metabolites will be obtained using a multiple session protocol that
accounts for variable subject position.

This work will greatly extend the clinical applications of MRSI by
providing volumetric metabolite distributions over a wide region of the
brain, with high sensitivity. As techniques are developed, they will
support ongoing clinical studies investigating changes of brain
metabolites associated with Alzheimer's disease and aging, epilepsy,
substance abuse, and schizophrenia.
Effective start/end date4/15/991/31/03


  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke: $184,168.00
  • National Institute of Neurological Disorders and Stroke: $235,067.00


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