TYPE D RETROVIRUSES AND MACAQUE IMMUNODEFICIENCY

Project: Research project

Description

We have recently described an acquired immunodeficiency syndrome in a
colony of captive macaque monkeys. This naturally occurring disease
provides an important opportunity to study acquired immunodeficiency states
in an animal model. We have recently isolated a Type D retrovirus from
affected macaques; preliminary data suggest that this agent may be
etiologic in the disease. We will: 1) Characterize Type D retrovirus isolates from macaques with the
immunodeficiency syndrome and compare them to previously described
retrovirus isolates; 2) Detail the natural history of the disease caused by this agent; 3) Investigate mechanisms of oncogenic transformation in the naturally
occurring and transmitted lymphomas in macaques; 4) Investigate the mechanisms by which this agent causes immune suppression; 5) Derive attenuated, vaccine strains of the virus.
StatusFinished
Effective start/end date8/1/8411/30/87

Funding

  • National Institutes of Health
  • National Institutes of Health

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Betaretrovirus
Macaca
Attenuated Vaccines
Haplorhini
Lymphoma
Acquired Immunodeficiency Syndrome
Animal Models
Viruses

ASJC

  • Medicine(all)