Description
We have recently described an acquired immunodeficiency syndrome in a
colony of captive macaque monkeys. This naturally occurring disease
provides an important opportunity to study acquired immunodeficiency states
in an animal model. We have recently isolated a Type D retrovirus from
affected macaques; preliminary data suggest that this agent may be
etiologic in the disease. We will: 1) Characterize Type D retrovirus isolates from macaques with the
immunodeficiency syndrome and compare them to previously described
retrovirus isolates; 2) Detail the natural history of the disease caused by this agent; 3) Investigate mechanisms of oncogenic transformation in the naturally
occurring and transmitted lymphomas in macaques; 4) Investigate the mechanisms by which this agent causes immune suppression; 5) Derive attenuated, vaccine strains of the virus.
colony of captive macaque monkeys. This naturally occurring disease
provides an important opportunity to study acquired immunodeficiency states
in an animal model. We have recently isolated a Type D retrovirus from
affected macaques; preliminary data suggest that this agent may be
etiologic in the disease. We will: 1) Characterize Type D retrovirus isolates from macaques with the
immunodeficiency syndrome and compare them to previously described
retrovirus isolates; 2) Detail the natural history of the disease caused by this agent; 3) Investigate mechanisms of oncogenic transformation in the naturally
occurring and transmitted lymphomas in macaques; 4) Investigate the mechanisms by which this agent causes immune suppression; 5) Derive attenuated, vaccine strains of the virus.
Status | Finished |
---|---|
Effective start/end date | 8/1/84 → 11/30/87 |
Funding
- National Institutes of Health
- National Institutes of Health
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Betaretrovirus
Macaca
Attenuated Vaccines
Haplorhini
Lymphoma
Acquired Immunodeficiency Syndrome
Animal Models
Viruses
ASJC
- Medicine(all)