Project: Research project

Project Details


DESCRIPTION (Adapted from applicant's abstract): This is an application for
a Mentored Clinical Scientist Development Award (K08). The Applicant is an
accomplished clinician shifting career focus from clinical work and medical
education to clinical research. The applicant's primary goal is to pursue a
career in clinical research focusing on questions driven by clinical
practice. Over the last two years, as a staff member of the newly formed
Joint Massachusetts General Hospitals-McLean Hospital Pediatric
Psychopharmacology Program, Dr. Joseph Biederman, Director, the applicant
has become increasingly involved in clinically-driven, programmatic research
focused on Tourette's Disorder. However, the absence of formal research
training and time to devote to research activities have been serious
impediments for rapid progress toward the goal of becoming an independent
investigator. By permitting the full focus of the applicant's time on
achieving the necessary tools to become an independent investigator, this
Award will allow the applicant to achieve these goals.

During the period of the Award the applicant will develop comprehensive
skills in clinical research methodology with a special focus on longitudinal
pros-pective studies. This will involve training in the following areas:
1) Exposure to Clinical Research (10 percent effort) including pediatric
psychopharmacology, genetics, epidemiology, longitudinal follow-up studies
on pediatric psychopharmacology protocols and longitudinal studies of ADHD
and related disorders. In addition, she will continue her work with
Dr.Jenike's group on the comparative phenomenology of Tourette's Disorder
and Obsessive-Compulsive Disorder and neuroimaging. 2) Formal Didactic
Training (20 percent effort) This part of the training will allow the
applicant to pursue further education in research methodology and
techniques. This will include course-work (detailed below) and tutorials at
the Harvard School of Public Health in biostatistics and epidemiology. (10
percent effort) The applicant will be tutored by Dr. Nan Laird, Chairman of
the Department of Biostatistics at the Harvard School of Public Health, on
statistical methods of longitudinal designs (10 percent effort). 3)
Exposure to an Established National TS Research Program (5 percent effort):
The applicant will meet monthly with Drs. James Leckman (Professor of
Psychiatry) and David Pauls (Associate Professor of Genetics) at the Yale
Child Study Center on methodologic approaches to TS, including developmental
psychopathology, clinical assess-ment, and family studies. 4) Exposure to
Basic Neuroscience (5 percent effort): The applicant will meet monthly with
Anne Young, M.D., Ph.D., Chairman of the Neurology Service at Massachusetts
General Hospital, and an internationally known neuroscientist with
longstanding interest in movement disorders and Tourette's Disorder, to
review basic neuroscience issues related to Tourette's Disorder. 5) The
Candidate's Mentored Research Study (40 percent effort) The applicant
proposes a study aimed at systematic character-ization and typology of 150
children and adolescents with Tourette's disorder who will then be followed
prospectively over four years. A comparison sample of 50 age, gender and
SES matched non-tic psychiatric controls will be assessed and systematically
followed over the same period. This study will be supervised and mentored
by Dr. Biederman.
Effective start/end date9/30/964/30/02


  • National Institute of Mental Health
  • National Institute of Mental Health: $149,654.00
  • National Institute of Mental Health
  • National Institute of Mental Health
  • National Institute of Mental Health


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