The role of PLIN5 deficiency in podocyte lipotoxicity and progression of Alport Syndrome

Project: Research project

Project Details

Description

PROJECT NARRATIVE Alport Syndrome (AS) is an inherited disease that affects the kidney, the ear, and the eye; patients with AS often require dialysis early in life. We show that deficiency of a protein named perilipin 5 (PLIN5) affects the respiratory function of podocytes, a key cellular constituent of the kidney filtration barrier. Findings from this proposal may allow for the identification of a new function of a drug called Ezetimibe which was developed for the cure of high cholesterol and may be helpful in preventing kidney disease in AS by regulating PLIN5 expression.
StatusActive
Effective start/end date1/1/2212/31/22

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases: $111,823.00

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