STROKE INCIDENCE AND PROGNOSIS IN A MIXED ETHNIC REGION

Project: Research project

Description

Mortality data suggest a higher risk of stroke among blacks, but there is
little data contrasting stroke incidence, risk and prognosis in blacks,
Hispanics and whites in the same population using similar methods. This
proposal will provide vital information to help develop targeted stroke
prevention strategies in population subgroups which can be used to
achieve Health Objective 15.2 of Healthy People 2000 to reduce stroke
deaths. This revised prospective, hospital and community based, 5-year study is
designed to determine the incidence of symptomatic stroke, the effect of
stroke risk factors and the 1-4 year stroke prognosis (stroke recurrence,
mortality and myocardial infarction) in white non-Hispanic, black
non-Hispanic and Hispanic men and women using the Northern Manhattan
population. There are 3 components to this study. First, case
surveillance will utilize hospital and community based survey networks
for enumeration of all first strokes. Strokes will be classified as
intracerebral hemorrhage, subarachnoid hemorrhage, or cerebral infarction
which will be subdivided based on the results of diagnostic evaluation.
Incidence of stroke subtypes by gender and race/ethnicity will be
estimated using the numbers from this study and adjusted 1990 census
data. Second, cerebral infarction risk factors will be identified
through a case-control study where cases (n=800) are uniformly evaluated
first cerebral infarct patients and controls (n=1600) randomly selected
from the community for stroke risk factor assessments. All eligible
subjects will be enrolled, interviewed and examined. Data will be
collected systematically through direct interview of the subject or
surrogate on demographics, stroke risk factors, neurological examination,
fasting lipid profile and results of diagnostic studies. Finally,
prospective, annual in-person and semi-annual telephone follow-up of the
cerebral infarct cases will measure stroke recurrence, myocardial
infarction and functional outcome. Exploratory univariate analyses will
be done to identify variables that are marginally dependent on the
outcome of interest and confirmatory multivariate analyses will be
performed for hypothesis testing with race/ethnicity and gender as
independent variables controlling for other risk factors.
StatusActive
Effective start/end date1/7/937/31/20

Funding

  • National Institutes of Health: $1,011,583.00
  • National Institutes of Health: $1,484,916.00
  • National Institutes of Health: $1,702,787.00
  • National Institutes of Health: $1,607,015.00
  • National Institutes of Health: $436,502.00
  • National Institutes of Health: $1,478,335.00
  • National Institutes of Health: $1,716,978.00
  • National Institutes of Health: $92,722.00
  • National Institutes of Health: $1,692,571.00
  • National Institutes of Health: $1,645,400.00
  • National Institutes of Health: $107,281.00
  • National Institutes of Health
  • National Institutes of Health: $1,726,580.00
  • National Institutes of Health: $1,750,070.00
  • National Institutes of Health: $1,176,199.00
  • National Institutes of Health: $1,440,422.00
  • National Institutes of Health: $1,450,555.00
  • National Institutes of Health: $141,611.00
  • National Institutes of Health: $1,492,420.00
  • National Institutes of Health: $1,731,055.00
  • National Institutes of Health: $1,593,459.00
  • National Institutes of Health: $1,172,605.00
  • National Institutes of Health
  • National Institutes of Health: $770,909.00
  • National Institutes of Health: $141,611.00
  • National Institutes of Health: $1,738,353.00
  • National Institutes of Health: $1,045,559.00
  • National Institutes of Health: $607,707.00
  • National Institutes of Health
  • National Institutes of Health: $1,644,341.00

Fingerprint

Stroke
Incidence
Hispanic Americans
Blood Vessels
Cohort Studies
Dementia
Population
Prospective Studies
Vascular Diseases
Brain
Public Health
Biomarkers
Adiponectin
Interviews
Fasting
Brain Diseases
Healthy People Programs
Cognitive Dysfunction

ASJC

  • Medicine(all)
  • Neuroscience(all)