SPECTROSCOPIC NMR IMAGING OF PROTON METABOLITES IN VIVO

Project: Research project

Description

Ischemia is a common disorder which causes increased tissue lactate
concentrations. The goal of this project is to develop improved
NMR spectroscopic imaging techniques to measure lactate, lipids and
other proton metabolites, in multiple volumes, in a short period
of time and without requiring a high degree of field homogeneity
and frequency selective water suppression. Improvements to the
Fourier method of spectroscopic imaging are proposed: i. Acquistion of data with high dynamic range, for imaging proton
metabolite distributions in tissues without the use of
frequency selective water suppression techniques. ii. Steady-State-Free-Precession data acquisition methods for
spectroscopic imaging, to maximize the efficiency of data
collection for observation of lactate distributions. iii. High speed spectroscopic imaging using multiple echoes. High dynamic range acquisition will be carried out with standard
spin echo, SSFP and multiple echo data acquisition methods, and
a comparison of these improved Fourier imaging methods carried
out. Computer processing and display utilities will be developed
for clinical applications and users, to rapidly analyse and review
multidimensional spectroscopic data. These techniques are to be applied for the observation of brain
lactate in vivo using animal models of stroke. Subsequently these
studies will be extended to observe other proton metabolites in a
variety of tissues in animals, and incorporated within ongoing
clinical spectroscopy studies to study patients with eschemia and
malignancy. This project is ultimately expected to improve
diagnosis and therapy of disorders such as stroke, myocardial
ischemia and cancer.
StatusFinished
Effective start/end date12/5/8811/30/97

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Magnetic Resonance Imaging
Lactic Acid
Stroke
Glutamic Acid
Protons
Observation
Spectrum Analysis
Ischemia
Taurine
Brain Ischemia
gamma-Aminobutyric Acid
Magnetic Resonance Spectroscopy
Water
Brain
Tissue Distribution
Animal Models
Lipids
Excitatory Amino Acids
Neoplasms
Amino Acids

ASJC

  • Medicine(all)