ROLE OF HYPERTENSION IN PROGRESSIVE GLOMERULAR DAMAGE

  • Raij, Leopoldo, (PI)

Project: Research project

Description

Hypertension is a frequent clinical accompaniment of glomerulonephritis.
It has long been considered that hypertension due to its injurious effects
on the renal vasculature may influence the course and/or progression of
glomerulonphritis. However, the mechanisms involved at the glomerular
level are not fully understood. Hence, experimental models in which
glomerulonephritis is accompanied by hypertension are necessary to evaluate
how these factors interact and contribute to acute and chronic glomerular
damage. We propose to induce glomerular injury selectively, to either the
mesangium or the peripheral capillary loop in Dahl and SHR rats. These
strains have a genetic predisposition to develop hypertension which has
features similar to that of human hypertension. Of particular importance
for our studies, is that in these two strains of rats; a) at similar levels
of systemic hypertension the hemodynamic determinants of glomerular
filtration are different and b) increased dietary salt is necessary for
hypertension to develop in Dahl rats but not in SHR rats. Thus, these
models of hypertension will afford us the unique opportunity to evaluate
sequentially the reciprocal relationship between hypertension and immune as
well as non-immune injury to the glomerulus. The proposed use of
morphologic techniques and their correlation to the physiologic
determinants of glomerular function will allow us to accomplish these
goals. These studies will contribute to the understanding of the
pathophysiological events that lead to progressive glomerular destruction
and renal failure.
StatusFinished
Effective start/end date4/1/833/31/87

Funding

  • National Institutes of Health

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Hypertension
Inbred Dahl Rats
Inbred SHR Rats
Wounds and Injuries
Genetic Predisposition to Disease
Glomerulonephritis
Renal Insufficiency
Theoretical Models
Salts
Hemodynamics
Kidney

ASJC

  • Medicine(all)