REGENERATION &FUNCTIONAL RECOVERY IN NEURAL TISSUE

  • Bunge, Mary B, (PI)
  • Fischbach, Gerald (PI)
  • Thach, W. Thomas (PI)
  • Willard, Mark (PI)
  • Daw, Nigel (PI)
  • Burton, Harold (PI)
  • Jones, Edward (PI)

Project: Research project

Description

Our overall goals are to increase fundamental knowledge of factors that
govern PNS and CNS nerve fiber growth and maintenance, as well as survival
of the parent neuronal cell body, and to better understand mechanisms
involved in the development of connections and adaptation and behavioral
plasticity in different areas of the CNS. The individual projects seek to
investigate: a) nonneuronal cell secretory products (both soluble and
insoluble) that promote CNS neurite growth and neuronal survival in the
animal and in culture, b) regenerative potential of cultured CNS growth
cones under differing environmental conditions to better understand
differences in growth capacity, c) distribution and molecular associations
of myosin, actin and several actin-associated proteins in cultured growth
cones to clarify mechanisms responsible for oriented growth of neuronal
processes, d) improving functional recovery following nerve repair by
ameliorating the response of sensory neurons to injury with the
administration of nerve growth factor, e) the role of synaptic transmitters
in visual cortex development, f) physiological and morphological substrata
for the process of adaptation of the vestibulo-ocular reflex, g) response
properties and connections of surviving somatic sensory cortex receiving
cortical lesions in infants vs. adults to search for the basis of observed
behavioral recovery in the infant, and h) cerebellar unit and spindle
afferent firing, reflex EMG changes and stiffness and damping of the
monkey's wrist during prevention of oscillations produced by novel loads
through adaptive (plastic) control of movement behavior. The investigators
have expertise in diverse experimental paradigms and techniques, yet share
strong common interests in pursuing study of mechanisms of neurite growth
and analyzing ways in which to best investigate adaptive behavior. Funding
is requested to support in a cost-effective way shared facilities (computer
expertise, electron microscopy and animal support) and to foster
interaction and collaboration among the participants to facilitate progress
toward the goal of better understanding basic mechanisms of regeneration
and useful plasticity.
StatusFinished
Effective start/end date4/1/793/31/91

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Regeneration
Growth
Neurites
Actins
Vestibulo-Ocular Reflex
Psychological Adaptation
Behavior Control
Visual Cortex
Electron Microscopy
Nerve Growth Factor
Sensory Receptor Cells
Myosins
Wrist
Nerve Fibers
Plastics
Reflex
Maintenance
Costs and Cost Analysis
Wounds and Injuries
Proteins

ASJC

  • Medicine(all)
  • Neuroscience(all)