PULMONARY MACROPHAGE METALLOPROTEINASES AND TIMP

Project: Research project

Description

Although the pathogenesis of lung injury is poorly understood, the
proteinase-antiproteinase theory of lung injury suggests that the
sparing or degredation of the alveolar connective tissue is due, at
least in part to the balance between secretion of
metalloproteinases and tissue inhibitor of metalloproteinase
(TIMP) by alveolar and interstitial macrophages. This application
proposes to determine the potential role of macrophage
metalloproteinases and TIMP in the pathogenesis of acute and
chronic lung disease. During the first year, she will compare,
through the use of rodent models of reversible and irreversible
lung injury, the ability of alveolar and interstitial macrophages to
secrete specific metalloproteinases and TIMP. During the next
two years, she will identify mediators that modulate the secretion
of these macrophage secretory products in different disease
states. In the final two years, she hopes to conduct independent
research to determine how these mediators modulate the
secretion of metalloproteinases and TIMP by macrophages.
StatusFinished
Effective start/end date10/1/7411/30/07

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Photopheresis
Hepatitis C
Interferon-alpha
Safety
Chronic Hepatitis C
Therapeutics
RNA
Polymerase Chain Reaction
Serum