PSYCHOPHYSIOLOGY OF CARDIOVASCULAR REACTIVITY

Project: Research project

Description

The objective is to conduct an integrated, multidisciplinary inquiry into
the psychophysiology of cardiovascular reactivity. Our goal is to use
psychophysiological, neurobiological, and behavioral methods to study
cardiovascular regulatory processes, relationships between behavior and
chronic disorders, and the development of efficacious treatments. The
Project consists of four major areas, together with Core facilities
supporting the program with biochemical urinary and plasma assays,
computation/instrumentation, and psychophysiological data collection. The
Cores contribute substantially to the implementation of each Project by
using common methodological approaches. Project 1 will examine why black
Americans have double the prevalence of hypertension as whites. The manner
in which biobehavioral and psychosocial factors influence cardiovascular
adjustments and neuroregulatory processes as a function of sex, race, and
blood pressure level (normotension vs. borderline hypertension) will be
examined during psychophysiological reactivity tasks in the laboratory and
during ambulatory heart rate, blood pressure, and hormonal monitoring in
natural settings. Project 2 will examine in mild or moderate hypertensives
how beta blockers differing in selectivity, lipophilicity, and intrinsic
sympathetic activity influence as a function of race and sex: (a)
hemodynamic and hormonal reactivity to standardized behavioral challenges
in the laboratory; (b) heart rate, blood pressure, and hormonal activity
during ambulatory monitoring, (c) cognitive performance, (d) mood, and (e)
fatigue. Project 3 will use psychophysiological reactivity tasks,
autonomic function tests, and ambulatory monitoring in Type 1 diabetics to
investigate: (a) interrelationships among autonomic function, glycemia,
cardiovascular and neurohormonal reactivity, and behavior; (b) putative
pathophysiological mechanisms responsible for autonomic neuropathy; (c)
influences of psychosocial stressors and personality factors on
pharmacologic, and/or behavioral interventions designed to exert glycemic
control and moderate autonomic reactivity; and (d) influences of
anti-hypertensive therapies upon glycemia, autonomic function, reactivity,
and behavior. Project 4 will examine in rabbits, the CNS mechanisms
underlying cardiovascular reactivity, and will assess the degree to which
sympathetic nervous system induced reactivity is attenuated by behavioral
conditioning or direct activation of sympathoinhibitory CNS pathways.
StatusFinished
Effective start/end date7/1/863/31/13

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,261,466.00
  • National Institutes of Health
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  • National Institutes of Health: $2,264,408.00
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  • National Institutes of Health: $217,521.00
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  • National Institutes of Health: $2,214,816.00
  • National Institutes of Health
  • National Institutes of Health
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  • National Institutes of Health: $2,255,531.00
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  • National Institutes of Health: $1,731,775.00
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  • National Institutes of Health: $2,251,080.00
  • National Institutes of Health: $1,771,942.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $76,454.00
  • National Institutes of Health
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  • National Institutes of Health
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  • National Institutes of Health
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  • National Institutes of Health: $1,981,804.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,940,307.00
  • National Institutes of Health: $1,283,840.00
  • National Institutes of Health
  • National Institutes of Health

Fingerprint

Ambulatory Monitoring
Psychophysiology
Blood Pressure
Hypertension
Heart Rate
Coronary Disease
Risk Management
Rabbits
Nervous System
Sympathetic Nervous System
Hemodynamics
Fatigue
Personality
Insulin Resistance
Atherosclerosis
Therapeutics
Psychology
Insulin
Social Environment
Pressure

ASJC

  • Medicine(all)