PREVENTION OF CHEMOTHERAPY-INDUCED HAIR LOSS

Project: Research project

Description

DESCRIPTION (provided by applicant): Current chemotherapy of cancer typically employs combinations of powerful anti-neoplastic agents. Most therapeutic combinations include anti-neoplastic agents that cause loss of scalp hair (chemotherapy-induced alopecia). Particularly, frequently used alopecia-inducing anti-neoplastic agents are cyclophosphamide, adriamycin, etoposide, taxol and vincristine. Alopecia is clearly the most feared side effect of chemotherapy. Patients have been known to refuse chemotherapy treatment because of it, and it seems not unreasonable to suspect that the psychological devastation resulting from this treatment-related hair loss may impact therapy success. To date, no elective preventive treatment is available to patients. Induction of a conserved protective response, the so-called stress protein response, was shown by many laboratories to protect various types of cultured cells against killing by essentially all classes of anti-neoplastic agents currently in clinical use. The present proposal will test in animal models the hypothesis that prior localized induction of the stress protein response in mitotically active cells of (scalp) hair follicles will protect these cells against killing by cyclophosphamide, adriamycin, etoposide, taxol and vincristine, resulting in the prevention of alopecia. Localization of the induction of the stress protein response will ensure that the preventive treatment will not interfere with the cytotoxic activity of the anti-neoplastic agents in cells other than those of hair follicles, i.e., that the preventive treatment of alopecia will not diminish chemotherapy efficacy.
StatusFinished
Effective start/end date7/1/036/30/08

Funding

  • National Institutes of Health: $253,837.00

Fingerprint

Alopecia
Drug Therapy
Heat-Shock Proteins
Hair Follicle
Vincristine
Etoposide
Paclitaxel
Scalp
Doxorubicin
Cyclophosphamide
Therapeutics
Cultured Cells
Animal Models
Psychology
Neoplasms

ASJC

  • Medicine(all)