Project: Research project

Project Details


DESCRIPTION (Adapted from the applicant's description): The institutions
included in this proposal have been part of the Pediatric Oncology Group
(POG) and received good performance scores during the past five years.
There are two primary goals of this proposed research; the first is to
accrue patients to the Group clinical trials in order to determine the
optimal care of children with all types of cancers. The second is to
contribute scientific expertise to the Group in areas of both patient care
and tumor biology. This proposed research will allow participation in POG
activities through a consortium effort of East Carolina University (ECU)
School of Medicine, Carolinas Medical Center, Medical University of South
Carolina (MUSC), Greenville Hospital, Presbyterian Hospital, and Memorial
Mission Hospital (The Carolinas' Consortium). In addition to these clinical
activities, their scientific efforts in next five years will include: (1)
development of new protocols for the treatment of children with cancer
focusing mainly on pediatric lymphomas; (2) expansion of studies of minimal
marrow residual disease (using RT-PCR analysis) and assessment of new
purging techniques in neuroblastoma; (3) participation in the laboratory
evaluation of folylpolyglutamate synthetase (FPGS) in lymphoblasts of newly
diagnosed patients; and (4) evaluation of the role hematopoietic growth
factors in the treatment of pediatric malignancies.
Effective start/end date6/15/9612/31/02


  • National Cancer Institute: $61,584.00
  • National Cancer Institute: $50,152.00


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