NUTRITION AND HIV INFECTION

  • Miller, Tracie L, (PI)
  • Knox, Tamsin (PI)
  • Wilson, Ira (PI)
  • Forrester, Janet (PI)
  • Shevitz, Abby (PI)
  • Spiegelman, Donna (PI)
  • Woods, Margo (PI)
  • Roubenoff, Ronenn (PI)
  • Goldin, Barry (PI)
  • Gorbach, Sherwood (PI)

Project: Research project

Description

The overall goal of this program is to elucidate the impact of HIV
infection on nutritional status and functional capacity of the host.
Three projects are proposed in this revised application: 1. A
longitudinal nutrition survey conducted in Boston and Baltimore which
measures dietary intake, body composition, biochemical and immunological
markers, GI function, state of energy metabolism, and quality of life
indicators; 2. A study of muscle physiology, cytokine production and
protein metabolism in response to acute exercise stress. In addition,
a program of exercise training will be evaluated for restoration of
muscle mass and strength; and 3. A study of longitudinal nutritional
survey and intervention studies in HIV-infected infants and children.
The choice of research topics is based on their perceived importance to
the general problem of nutrition and HIV infection, the limited, or in
some cases controversial, data on the topic, and the expertise of our
group. These studies are supported by four cores: administrative,
biostatistical/data management, biochemistry, and dietary assessment/body
composition. The project will enroll HIV-positive persons at all stages
of disease; however, special emphasis will be placed on the early
asymptomatic phases in order to identify the premonitory signs of weight
loss and nutritional deficits. The recruitment of underserved and poorly
studied populations, such as women, minorities and children, will receive
a high priority. Through these studies we hope to understand the
nutritional deficits in HIV infection, particularly in the early phases
when interventions might have a salutatory impact.
StatusFinished
Effective start/end date9/1/948/31/05

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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HIV
Body Composition
Growth
Fats
Exercise
Pediatrics
Cytokines
Quality of Life
Viral Proteins
Centers for Disease Control and Prevention (U.S.)
Energy Intake
Protease Inhibitors
Leucine
Therapeutics
Proteins
Electric Impedance
Nutritional Requirements
Body Water
Glucose
Control Groups

ASJC

  • Medicine(all)