NEUROTRAUMA CLINICAL RESEARCH CENTER

Project: Research project

Description

We propose a Neurotrauma Clinical Research Center at the University of
Miami/Jackson Memorial Hospital Medical Center. The Program consists of
five projects in clinical and basic science, and a Clinical Epidemiology
and Biostatistics Core, whose primary aims are to create a comprehensive
patient registry; to develop and implement prognostic indicators of
mortality/morbidity and outcome; and to provide ongoing support to present
and future projects. The Projects are unified by their concern with
potentially treatable or preventable pathomechanisms of traumatic CNS
injury. The role of brain temperature in modulating post-traumatic CNS
injury is a particular area of common concern. Program areas include: (a)
the clinical evaluation of altered brain temperature in patients with
severe acute head injury, analyzing the significance of brain hyperthermia
in relation to altered intracranial pressure, CSF metabolites, and clinical
outcome; (b) hippocampal dysfunction following fluid-percussion head injury
in the rat, integrating electrophysiological, neurotransmitter, and
behavioral measures; (c) an analysis of post-traumatic microvascular
integrity, blood-brain barrier, and cortical circuit function in the head-
injured rat in relation to altered brain temperature; (d) mechanisms of
injury-induced acute astrocytic swelling, with a focus on calcium and
calcium-dependent kinases; and (e) the therapeutic role of moderate
hypothermia in experimental contusive spinal cord injury. Our program
relies upon several unique and outstanding institutional resources a) a
1485-bed university-centered major medical center which receives the
overwhelming majority of head-injury and spinal cord-injury cases in Dade
County, with its 2 million population; b) a newly restructured Department
of Epidemiology and Public Health with expertise in data registries and
trial design; and c) major ongoing research programs in both cerebral
metabolism/ischemic cerebrovascular disease and in spinal cord injury,
providing breadth and depth of multidisciplinary collaborative expertise.
StatusFinished
Effective start/end date9/30/917/31/15

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,154,107.00
  • National Institutes of Health
  • National Institutes of Health: $993,340.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,262,529.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $965,470.00
  • National Institutes of Health: $37,857.00
  • National Institutes of Health: $901,724.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,228,231.00
  • National Institutes of Health: $937,348.00
  • National Institutes of Health: $915,716.00
  • National Institutes of Health
  • National Institutes of Health: $891,795.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,331,446.00
  • National Institutes of Health: $901,570.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,348,353.00
  • National Institutes of Health
  • National Institutes of Health: $1,348,353.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,348,354.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,207,940.00
  • National Institutes of Health: $1,259,846.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,348,352.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

Fingerprint

Wounds and Injuries
Percussion
Brain
Spinal Cord Injuries
Temperature
Astrocytes
Ephrins
Research
Craniocerebral Trauma
Eph Family Receptors
Head
Registries
Neuronal Plasticity
Biostatistics
Stem Cells
Fever
Traumatic Brain Injury
Cerebrovascular Disorders
Nerve Growth Factors
Therapeutics

ASJC

  • Medicine(all)
  • Neuroscience(all)