• Czaja, Sara J (PI)

Project: Research project

Project Details


DESCRIPTION (provided by applicant): The objective of this proposal is to
refine and test a multi-component psychosocial behavioral intervention to
reduce burden and depression among family caregivers of persons with
Alzheimer?s Disease or related disorders. This competing renewal will build
on existing infrastructures and results obtained from its parent multi-site
feasibility study, Resources for Enhancing Alzheimer?s Caregiver Health
(REACH). REACH, (funded by the National Institute on Aging (NIA) and the
National Institute for Nursing Research (NINR) U01-AG13305) explored the
effectiveness of different interventions to reduce burden and distress of
family caregivers in six participating sites. Detailed analyses of these data
suggest specific components of the REACH interventions that may be efficacious
in improving caregiver outcomes. The current study integrates identified
components from the REACH interventions and tests a single multi-component
intervention. This intervention will be evaluated among a sample of
geographically and racially/ethnically diverse caregiver populations. The
study design is a multi-site, two-group randomized clinical trial. The same
two conditions: an in-home multi-component intervention or a standardized
information only control condition will be implemented at five sites
(Birmingham, Memphis, Miami, Palo Alto, and Philadelphia), with the
Coordinating Center in Pittsburgh. Recruitment of 600 (120 per site)
caregiver-care recipient dyads will yield 510 completing the protocol (15%
attrition expected). Equal numbers of African Americans/Blacks,
Hispanics/Latinos, and Caucasian/Whites will be recruited and assigned to each
condition at each site. Phase 1 involves a refinement of the intervention and
training of the interventionists across sites; in Phase 2, the randomized
clinical trial will be conducted. The intervention is designed to enable
caregivers to earn and use cognitive and behavioral strategies, to impact both
care recipient behaviors (e.g. wandering) and their own behaviors (e.g.,
managing stress). The intervention will consist of 10 home visits by trained
staff plus 5 preplanned contacts with trained staff through innovative
technology over a six-month period. The technology will also provide access
to formal services, family, and other caregivers. A uniform battery of
predictor and outcome measures will be collected at baseline, three and six
months. Cost effectiveness and clinical significance of the two conditions
will also be evaluated.
Effective start/end date6/1/018/31/05


  • National Institutes of Health: $457,078.00
  • National Institutes of Health: $404,198.00
  • National Institutes of Health: $615,233.00
  • National Institutes of Health: $28,785.00


  • Medicine(all)


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