MOLECULAR MECHANISMS OF GROWTH CONE GUIDANCE

Project: Research project

Project Details

Description

DESCRIPTION (Adapted from the Applicant's Abstract): The goal of this project
is to test the validity of two general hypotheses: (1) the growth cone
reprogramming hypothesis, and (2) the unique dendritic guidance hypothesis.
According to the first hypothesis, axon guidance occurs through an interactive
reprogramming model, in which a growth cone must encounter specific molecular
cues early during its navigation so that it can undergo a reprogramming process
that enables it to properly respond to cues presented subsequently. The project
adopts in vivo single cell analysis, while taking the CNS midline as one
example of early guidance cues that may be responsible for growth cone
reprogramming. The second hypothesis is a model to explain why dendrites and
axons grow differently. According to this hypothesis, axons and dendrites grow
differently because they use a different set of growth cone receptor/signaling
molecules. A neuron is capable of targeting molecules differentially to its
axon or dendrites, thereby allowing the differential expression of receptors at
each site. Additional possibilities are that dendritic growth may depend on
axonal guidance, or that dendritic growth cones may be more susceptible to
neuronal activity. This project will begin to tease apart the unique dendritic
guidance hypothesis by using in vivo single cell analysis of dendritic
development as compared to axonal development. It is anticipated that the
present study will provide a better understanding of operational principles of
growth cone guidance.
StatusFinished
Effective start/end date5/1/962/28/04

Funding

  • National Institute of Neurological Disorders and Stroke: $289,830.00
  • National Institute of Neurological Disorders and Stroke: $289,830.00
  • National Institute of Neurological Disorders and Stroke: $50,000.00
  • National Institute of Neurological Disorders and Stroke: $314,830.00
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke: $289,830.00

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